RESUMEN
The concentrations of proinflammatory cytokines (IL-1beta, IL-6), vascular endothelium growth factor, tumor growth factor-beta, and insulin-like growth factor-1 were measured in the peritoneal fluid of patients with external genital endometriosis and healthy women by enzyme immunoassay. The effect of peritoneal fluid from patients with external genital endometriosis on proliferative activity of EA.Hy926 human endothelial cells was evaluated by the method based on the analysis of cell cycle by flow cytometry. The concentrations of IL-1beta, IL-6, and insulin-like growth factor-1 were increased in patients with endometriosis in comparison with healthy women. The peritoneal fluid from patients with endometriosis (but not from healthy women) significantly increased mitotic activity of endothelial cells and exhibited high angiogenic potential, which can promote implantation and growth of endometrial transplants. Presumably, insulin-like growth factor-1 stimulates this process.
Asunto(s)
Citocinas/biosíntesis , Endometriosis/metabolismo , Enfermedades de los Genitales Femeninos/metabolismo , Neovascularización Patológica , Peritoneo/metabolismo , Adulto , Estudios de Casos y Controles , Endometriosis/patología , Endotelio Vascular/metabolismo , Femenino , Enfermedades de los Genitales Femeninos/patología , Humanos , Técnicas para Inmunoenzimas , Inflamación , Factor I del Crecimiento Similar a la Insulina/biosíntesis , Interleucina-1/biosíntesis , Interleucina-6/biosíntesisRESUMEN
The paper presents the results of sanitary and hygienic investigations whose reason was the situation established with the removal of dumping earth in the dwelling area of Mitino Microdistrict 8 gamma. The removed dumping earth found to have formaldehyde, benzenes, acetaldehyde, phenols, aromatic hydro carbons, polyaromatic compounds was a source of bad smelling substances that had entered the ambient air. A special study of the earth showed that it might yield volatile and bad smelling compounds, such as organic sulfides, aldehydes, mercaptans, ketones, etc. Their harmful health effects (during operations and in the late period) seem to be unlikely. When such work is under way, it is necessary to inform the population about possible consequences.