Asunto(s)
Carcinoma 256 de Walker/terapia , Carubicina/uso terapéutico , Daunorrubicina/análogos & derivados , Hipertermia Inducida , Magnetismo , Animales , Cápsulas , Carcinoma 256 de Walker/mortalidad , Terapia Combinada/métodos , Estudios de Evaluación como Asunto , Compuestos Férricos/uso terapéutico , Masculino , Trasplante de Neoplasias , Ratas , Ratas Endogámicas , Factores de TiempoRESUMEN
The intravenous injection of ferromagnetic particles (FMP) was studied for its effect on the growth of Walker 256 carcinosarcoma in Wistar rats. The injection of FMP in a dose of 750 mg/kg increased the organism resistance to the tumour development against a background of phagocytic reaction activation in neutrophils. The injection of FMP in a dose up to 2 g/kg inhibited the phagocytic reactions of neutrophils and accelerated the tumour growth. The data obtained evidence that depending on the FMP dose the total reactivity of the organism may either increase or decrease, thus changing, respectively, its resistance to the development of the tumour process.
Asunto(s)
Carcinoma 256 de Walker/tratamiento farmacológico , Compuestos Férricos/uso terapéutico , Animales , Carcinoma 256 de Walker/sangre , Carcinoma 256 de Walker/inmunología , Carcinoma 256 de Walker/mortalidad , Relación Dosis-Respuesta a Droga , Portadores de Fármacos , Ensayos de Selección de Medicamentos Antitumorales , Imanes , Masculino , Trasplante de Neoplasias , Neutrófilos/efectos de los fármacos , Neutrófilos/inmunología , Tamaño de la Partícula , Fagocitosis/efectos de los fármacos , Fagocitosis/inmunología , RatasRESUMEN
In experiments on rats it has been shown that a single infusion of ultradispersed ferromagnetic particles (size from 0.2 to 1 micron) in a dose of 50 mg/kg leads to an increase in hemoglobin level, red blood cell and leucocyte content, to a growth of blood coagulation time and plasma fibrinolytic activity in the animals' blood, as well as to a rise in the level of neutrophil phagocytic reactions. A single infusion of magnetite particles of similar size, in a dose of 50 mg/kg, was not attended by the above changes, except for an increase in the neutrophil functional activity.