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Gene ; 506(2): 377-9, 2012 Sep 15.
Artículo en Inglés | MEDLINE | ID: mdl-22820389

RESUMEN

Results from the analysis of copy number variations (CNVs) in human pluripotent cell-derived neuroprogenitor cell lines (hiPSC and hESC-derived NPC) are presented. Two different types of CNVs were detected: a) CNVs inherited from the original source of pluripotent cells (hESC and hiPSC) and b) CNVs detected either in the original source of pluripotent cells or in the derived NPC cell lines but not in both at the same time. Our data suggest that submicroscopic chromosomal changes happened during culture and manipulation of cells and those differentiation procedures could result in gains and losses of genomic regions in pluripotent cell-derived neuroprogenitors. Overall, the results indicate that even chromosomally stable stem cell lines would need to be analyzed in detail by high resolution methodologies before their clinical use.


Asunto(s)
Variaciones en el Número de Copia de ADN , Células Madre Pluripotentes Inducidas/citología , Neuronas/citología , Diferenciación Celular , Línea Celular , Hibridación Genómica Comparativa , Dosificación de Gen , Inestabilidad Genómica , Humanos , Cariotipificación , Modelos Genéticos , Esquizofrenia/genética
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