RESUMEN

Root bark of Onosma echioides belonging to the family Boraginaceae is reported to be rich in naphthaquinones such as alkannins and shikonins. In this study, a dimer of alkannin/shikonin was isolated from the petroleum ether (60-80 C) extract of the bark, and the structure of the same was elucidated through spectral studies (UV, IR, NMR, MS and DEPT). The petroleum ether extract was found to contain 62.4% (w/w) of the dimer of alkannin/shikonin, and the compound is found to promote wound-healing process, when studied in the excision and incision wound models in albino rats.

Asunto(s)

Boraginaceae/química , Naftoquinonas/farmacología , Extractos Vegetales/farmacología , Cicatrización de Heridas/efectos de los fármacos , Animales , Estructura Molecular , Naftoquinonas/química , Extractos Vegetales/química , Raíces de Plantas/química , Ratas