RESUMEN

Characteristics of the fraction composition of extracellular mannan produced by Rhodotorula rubra are presented. Various lots of the polysaccharide mainly contained two fractions similar by their chemical structures and differing in the solution relative viscosity. HPLC was used for determining the molecular weight of the samples. In the isolated fractions it differed 3-5 fold. Relationship between the fibrinolytic activity of the polysaccharide and its molecular weight was revealed. The samples of mannan with the molecular weight of 400-500 kD had the highest capacity for lowering the fibrinogen blood levels in rats. The polysaccharide with the molecular weight of less than 100 kD had practically no fibrinolytic activity.

Asunto(s)

Fibrinógeno/antagonistas & inhibidores , Fibrinólisis , Mananos/análisis , Hongos Mitospóricos/metabolismo , Rhodotorula/metabolismo , Animales , Cromatografía en Gel , Fibrinolíticos , Técnicas In Vitro , Masculino , Mananos/farmacología , Peso Molecular , Ratas