RESUMEN
In 14 epileptic patients the authors determined concentrations of carbamazepine, its total and relative clearance, the period of half-elimination and the elimination constant. Blood levels of carbamazepine were assayed by gas liquid chromatography. The pharmacokinetic parameters have been found to be important for specifying the causes of dissociation between the level of blood anticonvulsant and the therapeutic effect when the attacks cannot be controlled or there were signs of intoxication. The mean diagrams of fluctuations of blood concentrations of the drug in the interval between single doses indicate the dependence of the clinical effect on the amplitude of fluctuations and create the prerequisites for the optimization of anticonvulsive therapy.
Asunto(s)
Carbamazepina/farmacocinética , Epilepsia/sangre , Adulto , Carbamazepina/administración & dosificación , Carbamazepina/sangre , Cromatografía de Gases , Evaluación de Medicamentos , Epilepsia/tratamiento farmacológico , Femenino , Semivida , Humanos , Masculino , Persona de Mediana Edad , Factores de TiempoRESUMEN
A total of 76 patients aged 18-39 with hyperprolactinemia were studied for the blood levels of serotonin and histamine and for the urinary ones of epinephrine, norepinephrine, dopa and dopamine. Blood levels of serotonin and histamine were recorded increased whereas the urinary levels of catecholamines were decreased. No correlation was shown between the intensity in the production of lactogenic hormone and those abnormalities found in the levels of the above mentioned amino groups. The shifts observed were supposed to reflect those general tendencies which took place in the central regulatory mechanisms of the gonadal system in patients with excessive production of lactogenic hormone.
Asunto(s)
Catecolaminas/sangre , Histamina/sangre , Hiperprolactinemia/sangre , Serotonina/sangre , Adenoma/sangre , Adenoma/metabolismo , Adolescente , Adulto , Enfermedad Crónica , Femenino , Galactorrea/sangre , Humanos , Trastornos de la Menstruación/sangre , Neoplasias Hipofisarias/sangre , Neoplasias Hipofisarias/metabolismo , Prolactina/metabolismoRESUMEN
Using gas liquid chromatography, the authors studied phenobarbital levels in the blood and cerebrospinal fluid of 41 epileptic patients following the administration of this anticonvulsant alone. The data obtained showed variations in the concentration of blood phenobarbital at various time intervals after the intake of the drug and a certain correlation between its level and the therapeutic effect. The ratio of phenobarbital level in the cerebrospinal fluid to that in the blood indicates that phenobarbital penetrates the blood-brain barrier. Fluctuations in the blood phenobarbital content from one administration to another is important for selecting its optimal dosage and the interval between intakes.