RESUMEN

In dogs, cats, rabbits, the effects of unique and chronic administration of L-DOPA (20-50 mg/kg daily) on central dopamine processes, behaviour, interrelations of sensory and motor regimens of the structures and on the transmitter metabolism, were studied. The interrelations of sensory and motor regimens became competitive, reciprocal changes occurred in dopaminergic and other transmitter (serotoninergic and acetylcholinergic) systems. The findings seem to be related to development of psychomotor excitation.

Asunto(s)

Receptores Dopaminérgicos/fisiología , Acetilcolinesterasa/metabolismo , Anfetamina/farmacología , Animales , Encéfalo/efectos de los fármacos , Encéfalo/enzimología , Encéfalo/fisiología , Gatos , Perros , Electroencefalografía , Reacción de Fuga/efectos de los fármacos , Reacción de Fuga/fisiología , Potenciales Evocados Visuales/efectos de los fármacos , Potenciales Evocados Visuales/fisiología , Levodopa/farmacología , Monoaminooxidasa/metabolismo , Conejos , Receptores Dopaminérgicos/efectos de los fármacos