RESUMEN

We assessed the diagnostic capability of the bentiromide test using a high-pressure liquid-chromatography method to analyze p-aminobenzoic acid and its metabolites in plasma as an indirect measure of exocrine pancreatic function. Mean total amine concentration in pancreatic-insufficient subjects was significantly lower than in control subjects. There were 3 of 15 false-negative results and no false-positive results. We conclude that this chromatographic method is an effective means of analyzing p-aminobenzoic acid and its metabolites after ingestion of bentiromide.

Asunto(s)

Ácido 4-Aminobenzoico/sangre , Cromatografía Líquida de Alta Presión/métodos , Insuficiencia Pancreática Exocrina/diagnóstico , para-Aminobenzoatos , Ácido 4-Aminobenzoico/metabolismo , Niño , Preescolar , Fibrosis Quística/sangre , Fibrosis Quística/complicaciones , Insuficiencia Pancreática Exocrina/sangre , Insuficiencia Pancreática Exocrina/etiología , Reacciones Falso Negativas , Femenino , Humanos , Lactante , Masculino