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Naltrexone (Trexan): a review of hepatotoxicity issues.

Verebey, K G; Mulé, S J.

NIDA Res Monogr ; 67: 73-81, 1986.

Artículo en Inglés | MEDLINE | ID: mdl-3092100

Asunto(s)

Hígado/patología , Naltrexona/toxicidad , Alanina Transaminasa/sangre , Animales , Aspartato Aminotransferasas/sangre , Humanos , Hígado/efectos de los fármacos , Naltrexona/farmacología , Narcóticos/toxicidad

A rapid, quantitative GLC method for the simultaneous determination of nicotine and cotinine.

Verebey, K G; DePace, A; Mulé, S J; Kanzler, M; Jaffe, J H.

J Anal Toxicol ; 6(6): 294-6, 1982.

Artículo en Inglés | MEDLINE | ID: mdl-7162139

RESUMEN

Published gas-liquid chromatographic (GLC) methods for the determination of nicotine and cotinine have proved impractical for the analysis of a large number of clinical samples. Significant improvements over other methods have been achieved, being low sample volume (0.5 mL plasma), rapid two-step extraction from plasma, no evaporation step, and good separation. The lower limits of sensitivity for nicotine and cotinine were 1 and 5 ng/mL, respectively. The method was validated by the analysis of plasma samples from cigarette-smoking volunteers. The method described permits the quick, routine determination of nicotine and cotinine in a large number of samples.

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Cotinina/sangre , Nicotina/sangre , Pirrolidinonas/sangre , Cromatografía de Gases , Humanos , Fumar

Quantitative determination of benzoylecgonine and cocaine in human biofluids by gas-liquid chromatography.

Kogan, M J; Verebey, K G; DePace, A C; Resnick, R B; Mulé, S J.

Anal Chem ; 49(13): 1965-9, 1977 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-907157

Asunto(s)

Cocaína/análogos & derivados , Cocaína/análisis , Cromatografía de Gases , Cromatografía Liquida , Cocaína/sangre , Cocaína/orina , Humanos

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