RESUMEN
The important role played by prostaglandins in the pathogenesis of coronary disease and essential hypertension is well known. The authors have attempted to reveal a relationship between blood levels of natural autoantibodies to PGF2 alpha and PGE2 and specific features of coronary disease and essential hypertension course and complications. A total of 87 subjects were examined, 23 of these--normal controls, 25 patients with myocardial infarction, 22 with angina pectoris, and 17 with essential hypertension. Solid-phase enzyme immunoassay was employed to detect anti-PGF2 alpha and anti-PGE2 antibodies. These antibodies were found in normal subjects, coronary patients and hypertensives. Blood levels of these antibodies correlated with some complications of coronary disease and essential hypertension. These results permit a hypothesis that the pathogenetic physiologic role of the detected natural antibodies to prostaglandins consists in their defense homeostatic function.
Asunto(s)
Autoanticuerpos/análisis , Enfermedades Autoinmunes/inmunología , Enfermedad Coronaria/inmunología , Dinoprost/inmunología , Dinoprostona/inmunología , Hipertensión/inmunología , Adulto , Anciano , Autoanticuerpos/inmunología , Enfermedades Autoinmunes/etiología , Enfermedad Coronaria/etiología , Humanos , Hipertensión/etiología , Persona de Mediana EdadRESUMEN
Concentration of PGF2 alpha were correlated to those of antiprostaglandin antibodies IgM and IgG to this mediator in donors and myocardial infarction patients. In donors correlation between PGF2 alpha concentration and IgG antibody levels is positive. In uneventful myocardial infarction relevant correlation partially recovered at the expense of IgM antibodies. This is not true for complicated myocardial infarction.
Asunto(s)
Anticuerpos/sangre , Dinoprost/inmunología , Infarto del Miocardio/inmunología , Adulto , Dinoprost/sangre , Humanos , Inmunidad Innata , Técnicas para Inmunoenzimas , Inmunoglobulinas/análisis , Persona de Mediana Edad , Infarto del Miocardio/sangreRESUMEN
Simultaneous levels of thrombin and its natural antibodies were comparatively analyzed in donors and patients with myocardial infarction. Thrombin and its antibody levels were demonstrated to remain unchanged in the healthy subjects. With myocardial infarction development, there was an increase in thrombin concentrations and a decrease in natural antithrombin antibodies at the same time. A linear correlation was established between the levels of thrombin and its antibodies and failure in diagnosing coagulative disorders by one of the parameters studied was also ascertained, which made it possible to introduce a new diagnostic criterion, namely an "antithrombin index" that enabled the groups of donors and patients to be differentiated.
Asunto(s)
Autoanticuerpos/análisis , Donantes de Sangre , Infarto del Miocardio/sangre , Trombina/análisis , Adulto , Anciano , Autoanticuerpos/inmunología , Femenino , Humanos , Síndromes de Inmunodeficiencia/etiología , Masculino , Persona de Mediana Edad , Infarto del Miocardio/inmunología , Trombina/inmunología , Trombosis/etiologíaRESUMEN
The ELISA test was performed on sera of normal donors and patients with myocardial infarction (MI) and essential hypertension (EH) to detect autoantibodies against prostaglandin F2 alpha (a-PGF2 alpha). The a-PGF2 alpha level was much higher after immune complexes dissociation. Baseline a-PGF2 alpha was elevated in EH patients with a sudden rise in blood pressure, and in MI patients without hypertension and unstable angina. MI patients with bradyarrhythmias also had elevated a-PGF2 alpha levels. Baseline a-PGF2 alpha was rather low in the sera of donors, chronic EH patients with hypertension and unstable angina, suggesting that a-PGF2 alpha has a physiological role to play.