RESUMEN
Analysis of element composition (sodium, potassium, magnesium, calcium, zinc, copper, iron, total sulfur and its compounds, chloride, and inorganic phosphorus) in 40 normal subjects (22 women and 18 men aged 17-30 years) showed that the composition is specific for each of the analyzed media (blood, plasma, erythrocytes, urine, saliva, exhaled air condensate). Element composition of exhaled air condensate is described for the first time. Analysis of element composition in 102 patients with asthma demonstrated characteristic shifts in the concentrations of some macro- and trace elements, which confirms the clinical significance of analysis and correction of deviations in the element composition of biological media.
Asunto(s)
Líquidos Corporales/química , Asma/metabolismo , Análisis Químico de la Sangre , Pruebas Respiratorias , Electrólitos/análisis , Eritrocitos/química , Femenino , Humanos , Masculino , Metales/análisis , Fósforo/análisis , Saliva/química , Compuestos de Sulfhidrilo/análisis , Azufre/análisis , UrinálisisRESUMEN
The process of oleandomycin inactivation in aqueous alkaline solutions with their heating was studied by using the microbiological method of the antibiotic content assay. The initial specific rate of inactivation of crystalline oleandomycin in buffer solutions and oleandomycin in the fermentation broth filtrate was evaluated. It was shown that the inactivation was retarded by the reaction products and the components of the fermentation broth filtrate. The production rate of oleandomycin anhydro derivatives amounting to 3-40 per cent of the total mass of the inactivation product was estimated by UV spectrophotometry.
Asunto(s)
Álcalis/farmacología , Calor , Modelos Químicos , Oleandomicina/farmacocinética , Agua/farmacología , Álcalis/administración & dosificación , Tampones (Química) , Fermentación/efectos de los fármacos , Concentración de Iones de Hidrógeno , Oleandomicina/antagonistas & inhibidores , Soluciones , Agua/administración & dosificaciónRESUMEN
Influence of pH, temperature and oleandomycin concentration on distribution of the antibiotic in the methylene chloride-aqueous medium system was studied. It was shown that the oleandomycin distribution coefficient did not depend on the antibiotic concentration within the ranges of 2000 to 20,000 micrograms/ml. An equation defining relationship between the oleandomycin distribution coefficient and pH of the aqueous phase is presented.