RESUMEN
BACKGROUND: Formoterol is a new beta 2 agonist with a duration of 8-12 hours. Albuterol is a beta 2-agonist with rapid onset of action and a duration of approximately 6 hours. OBJECTIVE: The aim of the present study was to compare the onset of action between formoterol and albuterol, both administered through a Turbohaler. MATERIAL AND METHOD: In a double-blind, parallel-group study design 36 patients were randomly allocated to receive either formoterol 12 microg or salbutamol 200 microg. The two drugs were administered through a Turbohaler system. Response (% forced expiratory volume in one second [FEV1]) was evaluated 3, 30 and 60 minutes after drug administration. RESULTS: The %FEV1 values at 3, 30 and 60 minutes were similar in both groups: 82 15.0 for formoterol and 82 14.4 for albuterol at 60 minutes (p > 0.05). CONCLUSIONS: Formoterol 12 microg has a similar onset of action and potency to albuterol 200 microg when administered via a Turbuhaler in children with a mild acute asthma crisis.
Asunto(s)
Agonistas Adrenérgicos beta/administración & dosificación , Albuterol/administración & dosificación , Asma/tratamiento farmacológico , Broncodilatadores/administración & dosificación , Etanolaminas/administración & dosificación , Inhaladores de Dosis Medida , Enfermedad Aguda , Adolescente , Agonistas de Receptores Adrenérgicos beta 2 , Agonistas Adrenérgicos beta/uso terapéutico , Albuterol/uso terapéutico , Broncodilatadores/uso terapéutico , Niño , Preescolar , Método Doble Ciego , Etanolaminas/uso terapéutico , Femenino , Volumen Espiratorio Forzado , Fumarato de Formoterol , Humanos , Masculino , PolvosRESUMEN
Background: Formoterol is a new β2-agonist with a duration of 8-12 hours. Albuterol is a β2-agonist with rapid onset of action and a duration of approximately 6 hours.Objective: The aim of the present study was to compare the onset of action between formoterol and albuterol, both administered through a Turbohaler®. Material and method: In a double-blind, parallel-group study design 36 patients were randomly allocated to receive either formoterol 12 μg or salbutamol 200 μg. The two drugs were administered through a Turbohaler® system. Response (% forced expiratory volume in one second [FEV1]) was evaluated 3, 30 and 60 minutes after drug administration. Results: The %FEV1 values at 3, 30 and 60 minutes were similar in both groups: 82 ± 15.0 for formoterol and 82 ± 14.4 for albuterol at 60 minutes (p > 0.05). Conclusions: Formoterol 12 μg has a similar onset of action and potency to albuterol 200 μg when administered via a Turbuhaler® in children with a mild acute asthma crisis (AU)
Información básica: Formoterol es un nuevo Beta2-agonista con un efecto de 8-12 horas. Salbutamol es un Beta2-agonista con una acción de comienzo rápido que dura aproximadamente 6 horas. Objetivo: El objetivo del presente estudio era comparar el inicio de la acción entre formoterol y salbutamol, ambos administrados mediante Turbohaler. Material y método: En un estudio doble ciego y de grupos paralelos se distribuyó aleatoriamente a 36 pacientes para recibir formoterol 12 mg o salbutamol 200mg. Los dos fármacos se administraron por medio de un sistema Turbohaler. Se evaluó la respuesta ( por cientoFEV1) 3, 30 y 60 minutos después de la administración del fármaco. Resultados: Los valores de por cientoFEV1 a los 3, 30 y 60 minutos fueron semejantes entre los grupos (p > 0,05), p. ej., 82 ñ 15,0 con formoterol y 82 ñ 14,4 con salbutamol a los 60 min. Conclusiones: Formoterol 12mg tuvo un inicio de acción y una potencia similares a las de salbutamol 200mg cuando se administraron a través de Turbuhaler a niños con crisis asmáticas agudas leves (AU)