RESUMEN
Statement of the Problem: Periodontitis is an inflammatory disease that causes bone loss. Some patients do not respond well to the classic treatment and need therapies that minimize bone loss, the main sequel of the disease. Chenopodium ambrosioides L. has stood out due to its anti-inflammatory and anti-oxidative activities. However, no study has yet investigated its effect on periodontitis. Purpose: This study aimed to evaluate the bone protective effect of Chenopodium ambrosioides L. (CAL) extract on ligature-induced periodontitis model in rats. Materials and Method: For this, a pre-clinical assay was performed, using male Wistar rats divided into 3 groups: Naive (N) (n=6), not submitted to any procedure; Saline (SAL) (n=6), submitted to ligature-induced periodontitis and receiving 2 ml/kg of 0.9% saline solution; and CAL extract, which was subdivided into 3 subgroups (n=6/subgroup) receiving the CAL at 3 (CAL3), 10 (CAL10) or 30 mg/kg (CAL30). All agents were given, by oral gavage, 30 min before periodontitis induction and daily until euthanasia (11th day). By then, maxillae were removed for macroscopic, histological, and histometric analyses. Kidneys, liver, and stomach were collected to evaluate the safety of CAL extract. High-performance liquid chromatography (HPLC) assay was used to investigate the flavonoid content in the extract. Results: Chenopodium ambrosioides L. extract at 30mg/kg showed a reduction by 58% in bone loss marked by an increase (+35%) in the number of osteoblasts and a reduction (-51%) on the number of osteoclasts (p< 0.05). No significant alteration in the liver, kidney, or stomach was seen. Rutin was the main flavonoid found. Conclusion: In summary, it was observed that Chenopodium ambrosioides L. extract has shown important anti-inflammatory and bone anabolic and anti-resorptive properties without causing toxicity in the main organs. Rutin, as the main flavonoid of the extract, seems to be responsible for the beneficial effect of this agent.
RESUMEN
Objetivo: caracterizar o perfil clínico e sociodemográfico de pessoas com úlceras venosas acompanhadas em ambulatório especializado de um hospital universitário. Método: estudo documental realizado em ambulatório de cirurgia geral de um hospital universitário. Realizou-se a revisão de 104 instrumentos aplicados na primeira consulta de enfermagem. Resultados: houve predominância do sexo feminino, com média de idade de 54 anos. A maioria não exercia atividade remunerada, sendo a ferida o motivo do afastamento das atividades laborais. A hipertensão arterial sistêmica e a obesidade foram as comorbidades mais prevalentes. A pessoa com úlcera venosa foi a principal envolvida no cuidado direto com a ferida. Conclusão: o perfil da população do estudo se mostra compatível com outros estudos em diferentes contextos do Brasil. Os resultados permitem uma reflexão acerca da assistência prestada e efetividade das intervenções implementadas.