RESUMEN
It is stated that therapeutic effect of humoral factors isolated from the cattle spleen is associated with its influence on alpha 2-macroglobulin (alpha 2-MG) performing a protective function. The results obtained permit recommending the isolated preparations to increase total resistivity of the organism under irradiation.
Asunto(s)
Traumatismos Experimentales por Radiación/prevención & control , Protección Radiológica/métodos , Timopoyetinas/farmacología , Hormonas del Timo/farmacología , alfa-Macroglobulinas/biosíntesis , Animales , Bovinos , Femenino , Masculino , Ratones , Ratones Endogámicos C57BL , Protectores contra Radiación , Timopoyetinas/administración & dosificación , Factores de TiempoRESUMEN
Patients with diabetes showed disorders of the dynamic balance of the system of protease inhibitors of the blood serum and lymphocytes which depend on the type of diabetes, severity and compensation of diabetes. Disorders of the proteolytic systems were accompanied by changes of hemostasis. It is of importance to control the above disorders in the complex treatment of diabetes mellitus and its complications.
Asunto(s)
Diabetes Mellitus Tipo 1/sangre , Diabetes Mellitus Tipo 2/sangre , Hemostasis , Serina Endopeptidasas/sangre , Adolescente , Adulto , Enfermedad Crónica , Humanos , Linfocitos/enzimología , Persona de Mediana Edad , Inhibidores de Serina Proteinasa/sangreRESUMEN
The role of serine proteases of trypsin type was shown in the pathogenesis of autoimmune processes and nonspecific reactivity in diabetes mellitus. The use of protease blockers and thymic hormonal factors was proposed for patients suffering from diabetes mellitus with changed immunological reactivity.
Asunto(s)
Diabetes Mellitus/sangre , Linfocitos/enzimología , Inhibidores de Proteasas/uso terapéutico , Serina Endopeptidasas/sangre , Adolescente , Adulto , Animales , Aprotinina/uso terapéutico , Femenino , Humanos , Masculino , Ratones , Ratones Endogámicos C57BL , Persona de Mediana Edad , Bazo/citología , Timo/citologíaAsunto(s)
Angiopatías Diabéticas/enzimología , Endopeptidasas/sangre , Linfocitos/enzimología , Adolescente , Adulto , Enfermedad Crónica , Nefropatías Diabéticas/enzimología , Retinopatía Diabética/enzimología , Humanos , Persona de Mediana Edad , Inhibidores de Proteasas , Serina Endopeptidasas , Tripsina/sangreAsunto(s)
Endopeptidasas/metabolismo , Bazo/enzimología , Linfocitos T/enzimología , Hormonas del Timo/inmunología , Animales , Técnicas In Vitro , Ratones , Ratones Endogámicos C57BL , Serina Endopeptidasas , Bazo/citología , Bazo/inmunología , Linfocitos T/efectos de los fármacos , Linfocitos T/inmunologíaAsunto(s)
Carbohidratos/sangre , Angiopatías Diabéticas/sangre , Lípidos/sangre , Adulto , Enfermedad Crónica , Humanos , Persona de Mediana Edad , VenasRESUMEN
A modified method for isolation of the calf thymus hormone thymopoetin has been developed. For hormone purification high-speed multi-stage centrifugation and gel-filtration on sefadexes were used instead of filtration. The thymus hormonal factor was identified on the basis of its ability to block neuromuscular transmission.