RESUMEN
The purpose of the study was to examine the effects of a workplace physical exercise intervention on subjective physical well-being, psychosocial functioning and general well-being. The study was a cluster randomized-controlled trial with the department (n=4) as the unit of randomization. The subjects (n=90) were office workers [mean age 45.7 (SD 8.5) years]. Psychosocial functioning and well-being variables were measured by descriptive visual rating scales. The cross-over design consisted of one 15-week intervention period of light resistance training and guidance and another 15-week period of no training and no guidance. The statistical analysis was based on linear mixed models. The active component of the intervention, light resistance training, resulted in a slight, but statistically significant, increase in subjective physical well-being (P=0.015). At the average training time of 5 min/working day (25 min/week) the average increase during the 15-week period was 4 units (95% confidence interval (CI) 1-7) and 5% (95% CI 1-9). The physical exercise intervention had no effect on somatic symptoms, anxiety, self-confidence, mood, mental stress at work, working atmosphere, life satisfaction or meaning of life. Daily light resistance training, conducted during the working day, had a positive direction on subjective physical well-being among office workers.
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Ejercicio Físico/psicología , Servicios de Salud del Trabajador , Estudios Cruzados , Femenino , Humanos , Relaciones Interpersonales , Masculino , Persona de Mediana EdadRESUMEN
Growing evidence from epidemiological studies suggests that osteoarthritis (OA) is linked to atheromatous vascular disease. This hypothesis article proposes that OA, or at least OA structural progression, may be an atheromatous vascular disease of subchondral bone. Further epidemiological studies, imaging investigations of relevant blood vessels, and trials of the effects of statins on the prevention and treatment of OA are needed to examine this hypothesis.
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Aterosclerosis/complicaciones , Huesos/irrigación sanguínea , Osteoartritis/etiología , Progresión de la Enfermedad , Humanos , Inhibidores de Hidroximetilglutaril-CoA Reductasas/uso terapéutico , Osteoartritis/terapiaRESUMEN
STUDY DESIGN: A subgroup analysis of a prospective, randomized controlled trial was performed. OBJECTIVE: To describe the cost effectiveness of periradicular infiltration with steroid in subgroups of patients with sciatica. SUMMARY OF BACKGROUND DATA: A recent trial on periradicular infiltration indicated that a methylprednisolone-bupivacaine combination had a short-term effect, as compared with that of saline. This report describes the efficacy and cost effectiveness of steroid in subgroups of patients with sciatic. METHODS: This study involved 160 patients with unilateral sciatica. Outcome assessments were leg pain (100-mm visual analog scale), disability on the Oswestry Low Back Disability Questionnaire, and the Nottingham Health Profile. Data on medical costs and sick leaves also were gathered. Patients were randomized for periradicular infiltration with either methylprednisolone-bupivacaine or saline. The adjusted between-group treatment differences at each follow-up assessment, the number of patients free of leg pain (responders, cutoff 75%), and efficacy by the area-under-the-curve method were calculated. For the cost-effectiveness estimate, the total costs were divided by the number of responders. The rate of operations in different subgroups was evaluated by Kaplan-Meier analysis. RESULTS: In the case of contained herniations, the steroid injection produced significant treatment effects and short-term efficacy in leg pain and in Nottingham Health Profile emotional reactions. For symptomatic lesions at L3-L4-L5, steroid was superior to saline for leg pain, disability, and straight leg raising in the short term. By 1 year, steroid seemed to have prevented operations for contained herniations, costing $12,666 less per responder in the steroid group (P < 0.01). For extrusions, steroid seemed to increase the operation rate, and the steroid infiltration was more expensive, costing $4445 per responder (P < 0.01). CONCLUSIONS: In addition to short-term effectiveness for contained herniations and lesions at L3-L4-L5, steroid treatment also prevented surgery for contained herniations. However, steroid was countereffective for extrusions. The results of the subgroup analyses call for a verification study.
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Anestésicos Locales/administración & dosificación , Bupivacaína/administración & dosificación , Glucocorticoides/administración & dosificación , Costos de la Atención en Salud , Metilprednisolona/administración & dosificación , Ciática/tratamiento farmacológico , Adulto , Anestésicos Locales/uso terapéutico , Bupivacaína/uso terapéutico , Análisis Costo-Beneficio , Método Doble Ciego , Combinación de Medicamentos , Femenino , Glucocorticoides/uso terapéutico , Humanos , Inyecciones Espinales , Desplazamiento del Disco Intervertebral/complicaciones , Pierna , Vértebras Lumbares , Masculino , Metilprednisolona/uso terapéutico , Persona de Mediana Edad , Dolor/fisiopatología , Ciática/etiología , Ausencia por Enfermedad , Cloruro de Sodio/administración & dosificación , Cloruro de Sodio/uso terapéuticoRESUMEN
STUDY DESIGN: A randomized, double-blind trial was conducted. OBJECTIVES: To test the efficacy of periradicular corticosteroid injection for sciatica. SUMMARY OF BACKGROUND DATA: The efficacy of epidural corticosteroids for sciatica is controversial. Periradicular infiltration is a targeted technique, but there are no randomized controlled trials of its efficacy. METHODS: In this study 160 consecutive, eligible patients with sciatica who had unilateral symptoms of 1 to 6 months duration, and who never underwent surgery were randomized for double-blind injection with methylprednisolone bupivacaine combination or saline. Objective and self-reported outcome parameters and costs were recorded at baseline, at 2 and 4 weeks, at 3 and 6 months, and at 1 year. RESULTS: Recovery was better in the steroid group at 2 weeks for leg pain (P = 0.02), straight leg raising (P = 0.03), lumbar flexion (P = 0.05), and patient satisfaction (P = 0.03). Back pain was significantly lower in the saline group at 3 and 6 months (P = 0.03 and 0.002, respectively), and leg pain at 6 months (13.5, P = 0.02). Sick leaves and medical costs were similar for both treatments, except for cost of therapy visits and drugs at 4 weeks, which were in favor of the steroid injection (P = 0.05 and 0.005, respectively). By 1 year, 18 patients in the steroid group and 15 in the saline group underwent surgery. CONCLUSIONS: Improvement during the follow-up period was found in both the methylprednisolone and saline groups. The combination of methylprednisolone and bupivacaine seems to have a short-term effect, but at 3 and 6 months, the steroid group seems to experience a "rebound" phenomenon.
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Anestésicos Locales/administración & dosificación , Bupivacaína/administración & dosificación , Glucocorticoides/administración & dosificación , Metilprednisolona/administración & dosificación , Ciática/tratamiento farmacológico , Adulto , Anestésicos Locales/economía , Anestésicos Locales/uso terapéutico , Bupivacaína/economía , Bupivacaína/uso terapéutico , Progresión de la Enfermedad , Combinación de Medicamentos , Costos de los Medicamentos , Femenino , Glucocorticoides/economía , Glucocorticoides/uso terapéutico , Costos de la Atención en Salud , Humanos , Inyecciones , Masculino , Metilprednisolona/economía , Metilprednisolona/uso terapéutico , Persona de Mediana Edad , Ciática/fisiopatología , Cloruro de Sodio/administración & dosificación , Cloruro de Sodio/economía , Cloruro de Sodio/uso terapéutico , Raíces Nerviosas Espinales/efectos de los fármacos , Resultado del TratamientoRESUMEN
The purpose of this study was to examine the effects of delayed-onset muscle soreness after a strength-training session on the motor performance of the upper extremities, including the reaction time, speed of movement, tapping speed and coordination. In addition, muscle strength, electromyographic (EMG) activity, creatine kinase (CK) and soreness responses were measured. The study was a randomised cross-over intervention study, where 30 subjects (divided into two groups, A and B) performed a 1-h muscle strength-training session of the upper extremities, and the responses were measured 48 h after that. All of the subjects experienced muscle soreness, which was evaluated on a visual analogue scale. The mean value of CK activity was 115 IU.l-1 before training and 1259 IU.l-1 after training (P < 0.001). There were no statistically significant differences in wrist flexion/extension muscle strength or EMG tests in either group. Isometric elbow extension strength decreased by 4% (P < 0.01) in group A, and elbow flexion strength decreased by 6% (P < 0.05) in group B. There were no statistically significant changes in simple reaction time, choice reaction time, or speed of movement or coordination in either group. However, tapping speed decreased by 2% (P < 0.05) in group A and by 6% (P < 0.001) in group B. Based on the results of this study, it seems that the feeling of incompetence to perform fast and accurate movements with sore muscles is mainly a subjective feeling, and it may be that the real effect of muscle soreness on motor performance is quite small, and presumably less than generally assumed.
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Movimiento/fisiología , Músculo Esquelético/fisiología , Dolor/fisiopatología , Adulto , Brazo/fisiología , Creatina Quinasa/metabolismo , Estudios Cruzados , Electromiografía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Dimensión del Dolor , Desempeño Psicomotor , Tiempo de Reacción/fisiologíaRESUMEN
CONTEXT: Lumbar disk disease (LDD) is one of the most common musculoskeletal diseases, with a prevalence of about 5%. A tryptophan (Trp) allele (Trp2) was recently discovered in the COL9A2 gene that is associated with dominantly inherited LDD but is only present in about 4% of Finnish patients with LDD. OBJECTIVE: To determine if other collagen IX gene sequence variations play a role in the pathogenesis of LDD. DESIGN AND SETTING: Case-control study conducted from February 1997 to May 1998 at university hospitals in Finland. PARTICIPANTS: A total of 171 individuals with LDD (evaluated clinically and by magnetic resonance imaging or computed tomography) and 321 controls without LDD (186 healthy individuals, 83 patients with primary osteoarthritis, 31 with rheumatoid arthritis, and 21 with chondrodysplasias). MAIN OUTCOME MEASURES: Frequencies of sequence variations covering the entire coding sequences and exon boundaries of the collagen IX genes, COL9A1, COL9A2, and COL9A3, which code for the alpha1, alpha2, and alpha3 chains of the protein, detected by conformation-sensitive gel electrophoresis and confirmed by sequencing, compared between individuals with and without LDD. RESULTS: Mutation analysis of all 3 collagen IX genes resulted in identification of an Arg103-->Trp (arginine-->tryptophan) substitution in the alpha3 chain (Trp3 allele). The frequency of the Trp3 allele was 12.2% in LDD cases, excluding 7 individuals who were carriers of the previously identified Gln326-->Trp (glutamine-->tryptophan) substitution in the alpha2 chain (Trp2 allele), and was 4.7% among controls. The difference in the frequency was statistically significant (P =.000013). Presence of at least 1 Trp3 allele increases risk of LDD about 3-fold. CONCLUSION: This study led to the identification of a novel common genetic risk factor for LDD, confirming that genetic risk factors likely play a significant role in LDD.
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Colágeno Tipo IX , Colágeno/genética , Desplazamiento del Disco Intervertebral/genética , Triptófano/genética , Adulto , Anciano , Alelos , Arginina , Estudios de Casos y Controles , Análisis Mutacional de ADN , Electroforesis , Finlandia , Predisposición Genética a la Enfermedad , Humanos , Desplazamiento del Disco Intervertebral/diagnóstico , Vértebras Lumbares , Imagen por Resonancia Magnética , Persona de Mediana Edad , Mutación Puntual , Reacción en Cadena de la Polimerasa , Factores de Riesgo , Tomografía Computarizada por Rayos XRESUMEN
The purpose of the study was to examine the relationship between the extremities in different aspects of motor performance, including simple reaction time, choice reaction time, speed of movement, tapping speed, and coordination, i.e., speed of movement/accuracy. 186 healthy randomly selected right-handed subjects (93 men, 93 women; aged 21-70 years) were measured on a test battery of five tests for both hands and feet. Correlations between the extremities in motor performance were highest between hands (r=.71-.80, p<.001) or between feet (r=.57-.88, p<.001) depending on the complexity of response for all subjects. These relations remained at almost the same magnitude even when age was eliminated. Correlations between the upper and lower extremities were lower (r = .40-.62). Correlations between extremities were lower for one age group (21-30 years) than for all subjects (21-70 years). These results showed that the motor performance for the hands is not a very good indicator of the motor performance of the lower extremities, especially in a homogeneous age group, and it seems that the lower extremities should be studied with specific motor performance tests.
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Extremidades/fisiología , Movimiento/fisiología , Desempeño Psicomotor/fisiología , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Tiempo de ReacciónRESUMEN
STUDY DESIGN: A cross-sectional study in sciatic population. OBJECTIVES: To evaluate the separate roles of nerve root entrapment-based on magnetic resonance imaging-and other discogenic pain mechanisms on disability and physical signs among symptomatic sciatic patients. SUMMARY OF BACKGROUND DATA: Data symptoms of sciatica are generally understood to be generated by nerve root compression, but other pain mechanisms of sciatica have been suggested. METHODS: The authors obtained magnetic resonance scans from 160 patients with unilateral sciatic pain. The patients reported the intensity of their back and leg pain and their back-specific disability. Clinical examination and magnetic resonance imaging (1.5 T) was performed on every patient. The degree of disc displacement, neural enhancement, and nerve root compression was evaluated from magnetic resonance scans. The correlations of symptoms and signs with magnetic resonance imaging findings were calculated. RESULTS: The degree of disc displacement in magnetic resonance imaging did not correlate with any subjective symptoms, nor did nerve root enhancement or nerve compression. Magnetic resonance imaging classification was associated, however, with straight leg raising restriction. In regression analysis, straight leg raising restriction was best explained with a simple classification of nonherniations versus herniations. CONCLUSIONS: The results suggest that a discogenic pain mechanism other than the nerve root entrapment generates the subjective symptoms among sciatic patients. The findings of this study thus indicate that magnetic resonance imaging is unable to distinguish sciatic patients in terms of the severity of their symptoms.
Asunto(s)
Imagen por Resonancia Magnética , Adulto , Anciano , Estudios Transversales , Femenino , Humanos , Desplazamiento del Disco Intervertebral/patología , Masculino , Persona de Mediana Edad , Ciática/patologíaRESUMEN
Alterations involved with the intervertebral disc degeneration are partly well described, however, it is not so well known how collagen network is affected by the disease. We analyzed the rate of collagen biosynthesis (estimated by the enzymic activities of prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase) and the level of hydroxylysylpyridinoline and lysylpyridinoline crosslinks both in normal (n=7) and degenerated (n=7) human annulus fibrosus. The activity of prolyl 4-hydroxylase was significantly increased in degenerated tissue. However, no significant changes in the collagen content or in the amount of hydroxylysylpyridinoline and lysylpyridinoline collagen crosslinks were observed. On the other hand, the content of soluble proteins was significantly increased. Our results suggest that collagen biosynthesis is increased in degenerated human annulus fibrosus, obviously to compensate the impairment of collagen fibers. The faster turnover of collagen in degenerated annulus fibrosus, suggested by the increased prolyl 4-hydroxylase activity and unchanged collagen content, seems not to cause any significant changes in its mature pyridinium crosslink concentrations.
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Disco Intervertebral/metabolismo , Procolágeno-Prolina Dioxigenasa/metabolismo , Proteínas/metabolismo , Enfermedades de la Columna Vertebral/metabolismo , Adulto , Aminoácidos/análisis , Colágeno/metabolismo , Humanos , Hidroxiprolina/análisis , Hidroxiprolina/metabolismo , Disco Intervertebral/química , Persona de Mediana Edad , Procesamiento Proteico-PostraduccionalRESUMEN
UNLABELLED: There was much enthusiasm about the development of computerized dynamometry in providing large quantities of data to objectively assess muscle performance. However, a much more basic issue arose questioning what these machines actual measure, particularly in pain populations. The purpose of the present study was to determine whether patients' self-reported disability and pain expression, as evaluated with simple questionnaires, were related to isokinetic performance in low back pain patients. METHOD: Oswestry Disability Questionnaires and pain drawings were collected from 76 patients undergoing isokinetic testing upon entering a physical rehabilitation program. Isokinetic trunk testing was performed in the standing position and results recorded for flexion and extension at speeds of 50 degrees, 100 degrees, and 150 degrees per second. RESULTS: Patients indicating minimal disability on the Oswestry questionnaire performed better than those indicating greater levels of disability (P < 0.05; ANOVA with Tukey adjustment for multiple comparisons). Patients with greater pain drawing scores, indicating unusual pain patterns, performed more poorly during isokinetic testing than those with normal drawings (P < 0.05). Regression analysis revealed that the lifting question from the Oswestry questionnaire, pain drawings scores, and sex were all significantly related to isokinetic performance and could account for 37.6-48.1% of the variance in performance (varying with speed of test). CONCLUSIONS: The results of this study indicate that isokinetic test values are significantly influenced by a patient's self-reported disability and pain expression, which can be evaluated using simple tools such as pain drawings and the Oswestry questionnaire. This study supports the supposition that dynamometry testing is related to factors other than muscle performance.
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Evaluación de la Discapacidad , Contracción Isométrica/fisiología , Dolor de la Región Lumbar/diagnóstico , Dimensión del Dolor/métodos , Autoevaluación (Psicología) , Diagnóstico por Computador , Femenino , Humanos , Dolor de la Región Lumbar/fisiopatología , Masculino , Persona de Mediana Edad , Encuestas y CuestionariosRESUMEN
STUDY DESIGN: A study comparing magnetic resonance imaging findings of degenerative changes in intervertebral discs in young patients with previous wedge-shaped compression fracture and age-matched and sex-matched control subjects. OBJECTIVES: To find out the role of fractures in disc degeneration and to assess the clinical outcome of the patients. SUMMARY OF BACKGROUND DATA: Several experimental studies have postulated that trauma is one of the major reasons for disc degeneration. Wedge compression fractures in vertebrae of children have been considered insignificant, but this has not been verified in the literature. METHODS: Fourteen patients 8.8 to 20.8 years of age (mean, 15.5 years) with a history of wedge-shaped vertebral compression fracture at least 1 year previously (mean, 3.8 years) and asymptomatic healthy control subjects were studied by thoracolumbar spine magnetic resonance imaging. The patients also underwent a clinical examination. RESULTS: Eight (57%) of the 14 patients had disc degeneration, and seven of them had it at the trauma level. Of these 7 subjects, 6 also had endplate damage at this level. The association between endplate damage and adjacent intervertebral disc degeneration was significant (P < 0.01). Only 2 of the patients were symptomatic. In the control group, only 1 subject had disc degeneration with endplate changes and disc herniation. CONCLUSIONS: The patients had more disc degeneration than did those in the control group. Endplate injury was strongly associated with disc degeneration. No correlation between previous vertebral fracture and back pain was seen in this study.
Asunto(s)
Disco Intervertebral , Fracturas de la Columna Vertebral/diagnóstico , Adolescente , Adulto , Niño , Femenino , Humanos , Disco Intervertebral/diagnóstico por imagen , Disco Intervertebral/lesiones , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/lesiones , Imagen por Resonancia Magnética , Masculino , Radiografía , Estudios Retrospectivos , Fracturas de la Columna Vertebral/diagnóstico por imagen , Vértebras Torácicas/diagnóstico por imagen , Vértebras Torácicas/lesionesRESUMEN
STUDY DESIGN: This was a cross-sectional observational study in which the abdominal aorta was evaluated for atheromatous lesions visible in computed tomographic scans in patients with and without low back pain. OBJECTIVES: To evaluate whether patients with low back pain have more atherosclerosis in the abdominal aorta than patients without low back pain and whether the severity of atherosclerosis in the abdominal aorta correlates with the grade of disc damage. SUMMARY OF BACKGROUND DATA: There are studies in which results indicate that insufficient blood supply may be a significant causative factor in disc degeneration. There are also studies in which smoking, one of the risk factors for arterial disease, has been correlated with low back pain. Calf pain has also been shown to correlate with low back pain. Results in a long-term follow-up study have further indicated an association between disc diseases and fatal ischemic heart disease. However, there seems to be only one postmortem study in which results show an association between atherosclerosis in the arteries of the lumbar area and disc diseases. METHODS: Computed tomographic images of 29 patients with low back pain, who had been evaluated with computed tomographic discography for diagnostic purposes, were evaluated for the quantity of atherosclerotic calcifications visible on computed tomographic scans of the abdominal aorta. A similar evaluation was performed in an age- and sex-matched control group of 52 patients without low back pain selected from among the patients referred for abdominal computed tomography. RESULTS: Sixteen (55%) of the 29 patients with low back pain had atherosclerotic calcifications visible on computed tomographic scans, whereas 11 (21%) of the 52 age-matched patients without low back pain were found to have aortic calcifications. Eleven (48%) patients with low back pain who were 50 years of age or less (n = 23) had aortic calcifications, whereas only 3 (8%) of the 36 control patients aged less than 50 years had aortic calcifications. There was no correlation between the amount of calcifications and the degree of disc degeneration assessed by computed tomographic discography. CONCLUSIONS: A significant association is indicated between atheromatous lesions in the abdominal aorta and low back pain.
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Aorta Abdominal/patología , Enfermedades de la Aorta/complicaciones , Arteriosclerosis/complicaciones , Disco Intervertebral/patología , Dolor de la Región Lumbar/complicaciones , Enfermedades de la Columna Vertebral/complicaciones , Adulto , Aorta Abdominal/diagnóstico por imagen , Enfermedades de la Aorta/diagnóstico por imagen , Arteriosclerosis/diagnóstico por imagen , Femenino , Estudios de Seguimiento , Humanos , Disco Intervertebral/diagnóstico por imagen , Dolor de la Región Lumbar/diagnóstico por imagen , Vértebras Lumbares/irrigación sanguínea , Vértebras Lumbares/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Enfermedades de la Columna Vertebral/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Arteria Vertebral/diagnóstico por imagenRESUMEN
OBJECTIVE: The purpose of this study was to determine whether pain location indicated in pain drawings was related to the specific lumbar disc level(s) that was abnormal in appearance and painful upon discographic injection. DESIGN: Data were collected prospectively. SETTING: This study was conducted in a spine specialty clinic. PATIENTS: The study group consisted of 187 patients (118 men, 69 women; mean age = 37.2 years, range = 18-62 years) with low back pain with or without leg pain. All patients were undergoing computed tomography (CT)/discography at the three lowest lumbar levels for diagnostic purposes. INTERVENTIONS: Pain drawings were completed the day of but prior to undergoing discography. Discographic pain responses were recorded with respect to the similarity to the patient's clinical symptoms. Pain drawings were classified based on the presence or absence of pain in five areas: low back and/or buttocks, posterior thigh, posterior leg, anterior thigh, and anterior leg. The drawings were scored with the system described by Ransford et al. (1976, Spine 1: 127-34), and those likely to be indicative of psychological problems were analyzed separately (n = 43). OUTCOME MEASURES: Results were determined by analyzing the relation between the location of pain in the drawings and the specific lumbar disc level(s) found to be painful and disrupted by discography. RESULTS: There was a significant relation between pain location indicated in the drawing and the lumbar disc level(s) identified as clinically painful and disrupted by CT/discography (p < 0.05, chi-square). Pain limited to the low back and buttocks was frequently associated with the absence of disc pathology (58.3%). When pain in the posterior thigh or leg was present but there was no pain in the anterior drawing, patients frequently had a positive L5-S 1 disc (> or =75%). In patients with anterior thigh pain, with or without posterior thigh or leg pain, the L4-5 disc was frequently symptomatic (>63%). The pattern of no posterior thigh or leg pain but with pain radiating into the leg anteriorly was most commonly associated with the L3-4 disc (71.4%). CONCLUSIONS: The results of this study indicate that pain drawings may be helpful in identifying which specific discs are associated with pain complaints. As with any evaluation, the drawings should be considered in combination with findings from other assessments.
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Dolor de Espalda/fisiopatología , Disco Intervertebral/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Adolescente , Adulto , Dolor de Espalda/diagnóstico por imagen , Nalgas/fisiopatología , Femenino , Humanos , Pierna/fisiopatología , Región Lumbosacra , Masculino , Ilustración Médica , Persona de Mediana Edad , Dolor/fisiopatología , Dimensión del Dolor/métodos , Muslo/fisiopatologíaRESUMEN
Intervertebral disc disease is one of the most common musculoskeletal disorders. A number of environmental and anthropometric risk factors may contribute to it, and recent reports have suggested the importance of genetic factors as well. The COL9A2 gene, which codes for one of the polypeptide chains of collagen IX that is expressed in the intervertebral disc, was screened for sequence variations in individuals with intervertebral disc disease. The analysis identified a putative disease-causing sequence variation that converted a codon for glutamine to one for tryptophan in six out of the 157 individuals but in none of 174 controls. The tryptophan allele cosegregated with the disease phenotype in the four families studied, giving a lod score (logarithm of odds ratio) for linkage of 4.5, and subsequent linkage disequilibrium analysis conditional on linkage gave an additional lod score of 7.1.
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Colágeno Tipo IX , Colágeno/genética , Predisposición Genética a la Enfermedad , Desplazamiento del Disco Intervertebral/genética , Ciática/genética , Adulto , Anciano , Alelos , Sustitución de Aminoácidos , Estudios de Casos y Controles , Codón , Colágeno/química , Femenino , Ligamiento Genético , Humanos , Desequilibrio de Ligamiento , Masculino , Persona de Mediana Edad , Mutación , Penetrancia , Polimorfismo Genético , Triptófano/genéticaRESUMEN
It has been found that the pain patterns in pain drawings are related to the presence of herniated disc identified by myelography. The purpose of this study was to determine whether the pattern of pain in the drawings or the type of pain indicated (aching, burning, numbness, pins and needles, stabbing) was related to the presence of symptomatic disc pathology identified by CT/discography. In a subgroup of patients who underwent myelography, the relationship of the drawings to myelographic findings was also investigated. Pain drawings were completed by 187 patients with low back and/or radicular pain who were undergoing CT/discography. The drawings were scored in two ways, first by the system described by Ransford and secondly by visual inspection. They were classified as being indicative, or not, of disc pathology. The CT/discograms were classified as disrupted, or not, and the pain responses were recorded upon injection of each disc, based on the similarity of the pain provoked to clinical symptoms. Among the 133 patients with discogenic pain confirmed by discography, 110 (82.7%) had pain drawings that were classified as indicative. Among the 45 patients without discogenic pain, 29 (64.4%) had pain drawings classified as non-indicative. Patients with discogenic pain used more symbols indicating burning pain and aching pain than did non-discogenic pain patients. Our results confirmed those reported earlier by Uden, who found a relationship between the pattern of pain in the drawings and myelographic findings. Pain drawings may be helpful in the diagnosis of symptomatic disc pathology.
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Desplazamiento del Disco Intervertebral/diagnóstico , Disco Intervertebral , Vértebras Lumbares/patología , Dimensión del Dolor , Adulto , Femenino , Humanos , Dolor de la Región Lumbar/diagnóstico , Masculino , Mielografía , Tomografía Computarizada por Rayos XRESUMEN
It has been found that one session of intense muscle strength training decreases muscle strength temporarily and causes neuromuscular fatigue in the trained muscles, but little attention has been given to the effects of neuromuscular fatigue on the other components of motor performance. The purpose of this study was to examine in normal healthy volunteers the effects of a 1-h strength training session on the motor performance of the upper extremity, including reaction time, speed of movement, tapping speed and coordination. Group of 30 healthy female volunteers, aged 29-47 years, were randomly divided into sub-groups, (A and B, n = 15 per group). Both groups first completed a set of motor performance tests on 3 consecutive days. On the 4th day, group A carried out a 1-h muscle strength training session of the upper extremities. Isometric muscle strengths and electromyogram (EMG) data were recorded before the training session. Immediately after the training session the same recordings were repeated, and additional motor performance tests were also performed. Group B carried out only the motor performance tests. The groups exchanged programmes the following week. The 1-h strength training session decreased the isometric muscle strength of wrist flexion by 18% (P < 0.001) and extension by 18% (P < 0.001) in group A, while in group B flexion strength decreased by 19% (P < 0.001) and extension strength by 17% (P < 0.001). All the measured EMG activations also decreased in both groups. There were no statistically significant differences in the results of the motor performance tests between the mean values of the three baseline measurements and the values recorded after the training session. The result was surprising, but straightforward; neuromuscular fatigue induced by a 1-h strength training session of the upper extremities had no effect on the motor performance functions of the hand, as indicated by reaction times, speed of movement, tapping speed and coordination, in these normal healthy female volunteers.
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Ejercicio Físico , Extremidades , Destreza Motora/fisiología , Músculo Esquelético/fisiología , Adulto , Electromiografía , Femenino , Humanos , Contracción Isométrica , Movimiento , Fatiga Muscular/fisiología , Organización y Administración , Tiempo de Reacción , Factores de Tiempo , MuñecaRESUMEN
STUDY DESIGN: A cohort study of 12,000 persons with a follow-up period ranging from birth to the age of 28 years. OBJECTIVES: To determine the cumulative incidence of lumbar disc disease leading to hospitalization in a well-defined geographic population, with special emphasis on age of onset and differences between the genders and among disease categories. SUMMARY OF BACKGROUND DATA: There are few published reports on low back pain in adolescence, and most of them are cross-sectional in design. METHODS: The Finnish National Hospital Discharge Register was used to identify all possible cases of lumbar disc disease. Copies of all hospital records regarding the diagnosis and course of the disease were collected and the hospitalizations were classified into three categories: 1) confirmed herniated nucleus pulposus (HNP), 2) unconfirmed HNP (sciatica symptoms without visible herniation), and 3) other low back diseases. The patients were classified according to the highest category of diagnosis achieved by each. RESULTS: Symptomatic low back pain leading to hospitalization first appeared around the age of 15 years, and the incidence rose more sharply from the age of 19, especially in men with other low back diseases. Men were hospitalized more than twice as often as women. CONCLUSIONS: Lumbar disc diseases leading to hospitalization begin early.
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Hospitalización/estadística & datos numéricos , Disco Intervertebral , Vértebras Lumbares , Enfermedades de la Columna Vertebral/epidemiología , Adulto , Edad de Inicio , Estudios de Cohortes , Femenino , Finlandia/epidemiología , Estudios de Seguimiento , Humanos , Incidencia , Desplazamiento del Disco Intervertebral/epidemiología , Masculino , Factores de TiempoRESUMEN
This study compared the effects of two neck training methods on workdays lost or flying under +Gz restrictions because of +Gz-related neck pain, and on neck muscle strength and the passive cervical range of motion among fighter pilots. One group (n = 10) participated in dynamic neck and shoulder muscle training, and another (n = 10) participated in helmet training with additional weights. The measurements were done at 0, 3, 6, and 12 months. The loss of workdays or restrictions in +Gz flights were recorded during the 1-year training period and the year preceding it. Neck muscle strength increased similarly in both groups. Nevertheless, during the training year, the pilots doing dynamic exercises had fewer sick leaves and +Gz restrictions than the pilots doing helmet exercises. Because the number of subjects was small and the study included no control group, firm conclusions on the effects of the training methods cannot be drawn.
Asunto(s)
Medicina Aeroespacial , Terapia por Ejercicio/métodos , Hipergravedad/efectos adversos , Capacitación en Servicio/organización & administración , Personal Militar/educación , Dolor de Cuello/prevención & control , Absentismo , Adulto , Humanos , Dolor de Cuello/etiología , Evaluación de Programas y Proyectos de SaludRESUMEN
This study aimed to assess the long-term outcome of progressive exercise and local pulsed ultrasound in the treatment of 30 chronic tennis elbow patients (2 men, 18 women, mean age 42.3 years). The patients were originally randomised into 1) four-step progressive exercise (EX, n = 16) and 2) local pulsed ultrasound (US, n = 14) treatment groups. Before the beginning of the treatment, the groups were similar in terms of pain scores, sick-leave days and duration of symptoms. The patients underwent an 8-week treatment intervention. Long-term follow-up evaluation of the patients was performed 1) prospectively using a pain questionnaire on VAS and pain drawings classified into 5 categories, and 2) retrospectively with a postal questionnaire (which was sent to the patients to fill in. Sick-leave days, medical and physiotherapy visits, operations, early retirements and job relocations were inquired in the postal questionnaire. The diagnosis-related sick-leave days of the patients were collected from the Database of the Social Insurance Institution of Finland and the number of operations from the local hospital register. Twenty-three patients (12 in the EX group and 11 in the US group) responded. The mean follow-up time was 36 months. After the treatment the patients in the EX group needed significantly less physiotherapy (p = 0.02), fewer medical consultations (p = 0.005) and other treatments and had fewer sick-leave days (p = 0.005) than before the treatment intervention. The patients in the US group had after the treatment intervention more 17 medical visits (ns), 291 sick-leave days (ns) and less 95 physiotherapy visits (ns) than before the treatment. Eight patients (67%) in the EX group and 5 (45%) in the US group still held their previous job, while two patients in the US group, but none in the EX group were absent from work because of the tennis elbow syndrome. The patients in the EX group reported significantly lower pain scores on VAS than those in the US group. The mean pain drawing category was 1.5 in the EX group and 2.7 in the US group (p = 0.008). All the pain scores and pain drawing categories in the EX group had changed to be significantly better than in the US group, where only pain under strain had significantly improved. Because of resistant symptoms, 5 patients were operated in the US group and one in the EX group. Neither spontaneous healing, nor self-limiting of the disorder were noted during the follow-up period. The progressive exercise evaluated in this study showed beneficial long-term effects compared to ultrasound treatment in terms of pain alleviation and working ability, and the functional overall condition of the exercise patients was also better. Exercise may be able to prevent chronicity and should hence be tried and recommended.