RESUMEN
Rivaroxaban is one of the new oral anticoagulants (NOACs). It has many potential advantages in comparison with Vitamin K Antagonists (VKA). It has a predictable anticoagulant effect and does not theoretically require biological monitoring. It is also characterized by less food and drug interactions. However, due to major risks associated with over- and under-dosage, its optimal use in patients should be carefully followed by health care professionals. The aim of this article is to provide recommendations for pharmacists on the practical use of Xarelto in its different approved indications. This document is adapted from the practical user guide of rivaroxaban which was developed by an independent group of Belgian experts in the field of thrombosis and haemostasis.
Asunto(s)
Anticoagulantes/uso terapéutico , Morfolinas/uso terapéutico , Tiofenos/uso terapéutico , Trombosis de la Vena/prevención & control , Anticoagulantes/administración & dosificación , Anticoagulantes/efectos adversos , Humanos , Morfolinas/administración & dosificación , Morfolinas/efectos adversos , Farmacéuticos , Rivaroxabán , Tiofenos/administración & dosificación , Tiofenos/efectos adversos , Vitamina K/antagonistas & inhibidoresRESUMEN
OBJECTIVE: The aim of the present study was to analyse the anatomical patterns of the above knee great saphenous vein (GSV) and its tributaries in limbs with varicose veins in view of potential suitability for endovenous treatment. METHODS: Limbs of a consecutive series of new patients with varicose veins presenting at the phlebologic clinic during a 4 month period were studied. In 73 limbs of 56 patients with varicose veins and both saphenofemoral junction and GSV reflux, anatomical patterns of the above knee GSV were defined as: --'complete' GSV: main trunk visualised within the saphenous compartment from the groin to the knee; --'incomplete' GSV: main trunk partially visualised from the groin to mid thigh with a non-refluxing mostly hypoplastic distal GSV and a superficial tributary vein (STV) parallel to the GSV. RESULTS: 51 limbs (70 %) had a 'complete' GSV. In 4 of these 51 limbs reflux passed from the main GSV trunk to a STV at mid thigh level leaving a non-refluxing part of the GSV from mid thigh to the knee. CONCLUSION: In only 64% of limbs with varicose veins the entire above knee GSV was involved in the disease. This may have implications for endovenous treatment strategy.
Asunto(s)
Vena Safena/patología , Vena Safena/fisiopatología , Várices/diagnóstico , Adulto , Angioplastia , Ablación por Catéter , Estudios de Cohortes , Femenino , Vena Femoral/diagnóstico por imagen , Vena Femoral/patología , Vena Femoral/fisiopatología , Humanos , Rodilla , Masculino , Persona de Mediana Edad , Selección de Paciente , Flujo Sanguíneo Regional/fisiología , Vena Safena/diagnóstico por imagen , Ultrasonografía , Várices/fisiopatología , Várices/cirugíaRESUMEN
OBJECTIVE: The aim was to describe the results of starting a foam sclerotherapy service, focussing on patients with complicated venous disease. METHODS: Consecutive patients undergoing ultrasound-guided foam sclerotherapy for truncal varicose veins underwent clinical and hand-held Doppler assessment at 2 weeks and venous duplex imaging at 6 months. RESULTS: One hundred and eighty-five truncal veins were treated in 165 patients. A high proportion of veins were complicated (109 CEAP classes 4-6, 76 CEAP 1-3). Ninety-one percent (168) had a single treatment session. After 2 weeks, ninety-three percent (136/147) of the truncal veins appeared occluded on hand-held Doppler examination. Ten percent (15/147) of patients had remaining visible varicosities in the lower leg. After six months, the truncal vein remained occluded in 74% (68/92), was partially occluded in 10% (9/92) and fully patent in 16% (15/92). There was no significant difference in occlusion rates between: primary (45/60-75%) and recurrent (23/32-72%) veins; CEAP 2-3 (22/30-73%) and CEAP 4-6 (46/62-74%) veins; veins with diameter <7 mm (29/38-76%) or > or =7 mm (13/23-57%). No patient had evidence of deep vein thrombosis, though nine (10%) had new segmental deep venous reflux compared with pre-treatment scans. CONCLUSION: Foam sclerotherapy was equally effective for complicated and uncomplicated varicose veins.
Asunto(s)
Escleroterapia , Ultrasonografía Doppler Dúplex , Ultrasonografía Intervencional , Várices/diagnóstico por imagen , Várices/terapia , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Evaluación de Programas y Proyectos de Salud , Recurrencia , Índice de Severidad de la Enfermedad , Factores de Tiempo , Resultado del TratamientoRESUMEN
BACKGROUND: Neovascularisation at the sapheno-femoral junction (SFJ) ligation site in the groin may occur within one year after great saphenous vein (GSV) surgery. Several anatomical and prosthetic barrier techniques have been proposed to prevent this evolution. OBJECTIVE: A prospective study examined whether closing the cribriform fascia could reduce the incidence of postoperative neovascularisation in the groin. PATIENTS AND METHODS: Patients with primary varicose veins and incompetence at the level of the SFJ were included. After SFJ ligation in 235 limbs of 193 patients an anatomical barrier was constructed by closing the cribriform fascia. Postoperative duplex scanning was performed after 2 and 12 months. Results were compared with historical control groups in which either a silicone patch saphenoplasty or no barrier technique had been performed. RESULTS: After one year, 10 limbs had developed recurrent thigh varicose veins and duplex scan showed neovascularisation at the SFJ ligation site in 15 of 223 re-examined limbs (6.7%). This was comparable to the group of 191 limbs with silicone patch saphenoplasty (5.2%) (P=0.526) and superior to the group of 189 limbs without barrier (14.8%) (P<0.01). CONCLUSION: Interposition of an anatomical barrier by closing the cribriform fascia after SFJ ligation reduced ultrasound detected neovascularisation at the SFJ after one year. In primary varicose vein operations application of an anatomical barrier technique (without prosthetic patch) is an alternative option to prevent postoperative neovascularisation.
Asunto(s)
Fasciotomía , Vena Femoral/cirugía , Neovascularización Patológica/prevención & control , Vena Safena/cirugía , Várices/cirugía , Procedimientos Quirúrgicos Vasculares/efectos adversos , Adulto , Estudios de Casos y Controles , Femenino , Vena Femoral/diagnóstico por imagen , Estudios de Seguimiento , Humanos , Incidencia , Ligadura/efectos adversos , Masculino , Persona de Mediana Edad , Neovascularización Patológica/diagnóstico por imagen , Neovascularización Patológica/epidemiología , Neovascularización Patológica/etiología , Estudios Prospectivos , Vena Safena/diagnóstico por imagen , Prevención Secundaria , Índice de Severidad de la Enfermedad , Siliconas/uso terapéutico , Factores de Tiempo , Resultado del Tratamiento , Ultrasonografía , Várices/diagnóstico por imagen , Procedimientos Quirúrgicos Vasculares/métodosRESUMEN
OBJECTIVE: To investigate whether the results of duplex examination 1 year after sapheno-femoral junction (SFJ) ligation might be helpful in predicting long-term results after 5 years. PATIENTS AND METHODS: Follow-up data concerning patients operated on for primary or recurrent varicose veins of the great saphenous vein were studied 1 year and 5 years after surgery, focusing on the thigh and groin region. Clinical examination was undertaken to detect recurrent thigh varicose veins. The site of SFJ ligation was carefully screened for any signs of neovascularisation by duplex ultrasound. Sensitivity, specificity, positive and negative predictive value of the 1-year duplex scan were calculated, based upon the outcome of a further duplex scan 5 years following surgery. RESULTS: A total of 100 limbs were studied: 50 limbs operated on for primary varicose veins and 50 limbs for recurrent varicose veins. The 1-year duplex ultrasound of the SFJ ligation site had a sensitivity of 80%, a specificity of 91%, a positive predictive value of 70% and a negative predictive value of 95% in assessing the 5 year recurrence rate. CONCLUSION: A postoperative duplex scan of the SFJ 1 year after varicose vein surgery to the great saphenous vein predicts which patients are most likely to have a good outcome 5 years after surgery. The 1-year duplex scan is a reliable diagnostic tool for future studies evaluating the effect of new methods of treating sapheno-femoral incompetence.