RESUMEN

The myelodysplastic syndromes (MDS) are a clinically heterogeneous group of hematologic disorders. Cytogenetic analysis is crucial as it can provide both diagnostic and prognostic information. Herein, 32 cytogenetically normal patients with primary MDS were analyzed both by multiple FISH probes on interphase nuclei (FISH panel testing) and by M-FISH (metaphase nuclei). One patient had a chromosome 13q-arm deletion, while the remaining 31 patients had normal results. These findings confirm standard cytogenetics as an excellent technique in identifying the common chromosomal abnormalities associated with MDS and suggest limited utility for either a FISH panel test or M-FISH in primary MDS.

Asunto(s)

Células de la Médula Ósea/patología , Deleción Cromosómica , Cromosomas Humanos Par 13 , Síndromes Mielodisplásicos/genética , Anemia Refractaria con Exceso de Blastos/diagnóstico , Anemia Refractaria con Exceso de Blastos/genética , Núcleo Celular/genética , Mapeo Cromosómico , Enfermedades Hematológicas/genética , Enfermedades Hematológicas/patología , Humanos , Hibridación Fluorescente in Situ , Interfase , Cariotipificación , Metafase , Monosomía , Síndromes Mielodisplásicos/patología , Variaciones Dependientes del Observador , Valores de Referencia , Trisomía