RESUMEN

During the development of liver fibrosis in rats by an individual dose-titrated CCl4 administration, hepatic proton spin-lattice relaxation time (T1) has been measured in vivo every 2 weeks for 8 weeks. Liver content of collagen, triglycerides and water has been measured biochemically in biopsy material. After 4 weeks of CCl4 treatment, T1 increased significantly and remained at the same level, whereas liver collagen reached its maximum at 8 weeks. It is concluded that, under our experimental conditions, increased hepatic T1 represents drug-induced edema and that hepatic T1 is not a reliable noninvasive parameter for developing liver fibrosis in vivo.

Asunto(s)

Cirrosis Hepática Experimental/diagnóstico , Imagen por Resonancia Magnética/métodos , Animales , Tetracloruro de Carbono , Hidroxiprolina/metabolismo , Procesamiento de Imagen Asistido por Computador , Hígado/metabolismo , Hígado/patología , Cirrosis Hepática Experimental/inducido químicamente , Cirrosis Hepática Experimental/patología , Factores de Tiempo , Triglicéridos/metabolismo