1.
Org Lett
; 18(19): 4782-4785, 2016 10 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27622964
RESUMEN
A Cu(I)-catalyzed coupling of a ω-chloro ketone, a primary amine, and an alkyne is described. This protocol allows for the synthesis of α-quaternary carbons in 2-alkynyl-substituted N-heterocycles. The key step is the in situ generation of a cyclic ketiminium species, which has enhanced reactivity for alkynylation compared to acyclic ketiminium species.