RESUMEN

The HFE gene encodes a protein involved in iron homeostasis; individuals with mutations in both alleles develop hemochromatosis. 27% of the French population is heterozygous for mutations in this gene. We found that 80% of the French athletes who won international competitions in rowing, Nordic skiing and judo display mutations in one allele of HFE, thus demonstrating the existence of a favourable phenotype linked to this heterozygosity.

Asunto(s)

Rendimiento Atlético , Proteína de la Hemocromatosis/genética , Heterocigoto , Desarrollo de Músculos/genética , Mutación , Resistencia Física/genética , Adolescente , Adulto , Alelos , Sustitución de Aminoácidos , Atletas , Femenino , Francia , Frecuencia de los Genes , Estudios de Asociación Genética , Proteína de la Hemocromatosis/metabolismo , Humanos , Masculino , Artes Marciales , Persona de Mediana Edad , Esquí , Adulto Joven