RESUMEN
Patients with coronary artery disease are advised to augment their dietary linoleic acid intakes at the expense of saturated fatty acids. We investigated whether the dietary linoleic acid intake of 57 patients with coronary artery disease (47 males, 10 females; ages 61 +/- 10 years) in Curaçao is higher as compared with 77 controls (51 males, 26 females; ages 56 +/- 7 years). For this, we measured plasma cholesterol ester fatty acids, which reflect the dietary fatty acid composition of the preceding weeks. Patients with coronary artery disease and controls had minor differences in cholesterol ester fatty acids. Their cholesterol ester linoleic acid content suggests that the dietary polyunsaturated/saturated fatty acid ratio is far below 1. Comparison with data reported for The Netherlands, Greenland and Crete showed that the dietary fatty acid composition in Curaçao is typically Western with a high intake of saturated fatty acids, a low intake of monounsaturated fatty acids and the consumption of linoleic acid as the predominant polyunsaturated fatty acid. Intake of long chain polyunsaturated fatty acids from fatty fish is low. Reduction of dietary saturated fatty acids, augmentation of fish consumption, and an increase of the alpha-linolenic/linoleic acid ratio are likely to be of benefit to both primary and secondary prevention from coronary artery disease in Curaçao.
Asunto(s)
Enfermedad Coronaria/prevención & control , Grasas de la Dieta/administración & dosificación , Ácidos Grasos/administración & dosificación , Población Urbana , Adulto , Anciano , Ésteres del Colesterol/sangre , Enfermedad Coronaria/sangre , Enfermedad Coronaria/etiología , Grasas de la Dieta/efectos adversos , Ácidos Grasos/efectos adversos , Ácidos Grasos/sangre , Conducta Alimentaria , Femenino , Aceites de Pescado/administración & dosificación , Humanos , Ácido Linoleico , Ácidos Linoleicos/administración & dosificación , Masculino , Persona de Mediana Edad , Factores de Riesgo , VenezuelaRESUMEN
Patients with coronary artery diseases are advised to augment their dietary linoleic acid intakes at the expense of saturated fatty acids. We investigated whether the dietary linoleic acid intake of 57 patients with coronary artery disease (47 males, 10 females; ages 61 ñ 10 years) in Curacao is higher as compared with 77 controls (51 males, 26 females; ages 56 ñ 7 years). For this, we measured plasma cholesterol ester fatty acids, which reflect the dietary fatty acid composition of the preceeding weeks. Patients with coronary artery disease and controls had minor differences in cholesterol ester fatty acids. Their cholesterol ester linoleic acid content suggests that the dietary polyunsaturated/saturated fatty acid ratio is far below 1. Comparison with data reported for the the Netherlands, Greenland and Crete showed that the dietary fatty acid composition in Curacao is typically Western with a high intake of saturated fatty acids, a low intake of monounsaturated fatty acids and the consumption of linoleic acid as the predominant polyunsaturated fatty acid. Intake of long chain polyunsaturated fatty acids from fatty fish is low. Reduction of dietary saturated fatty acids, augmentation of fish consumption, and an increase of the Ó-linolenic/linoleic acid ratio are likely to be of benefit to both primary and secondary prevention from coronary artery disease in Curaco.
Asunto(s)
Adulto , Femenino , Humanos , Persona de Mediana Edad , Adolescente , Grasas de la Dieta/sangre , Ésteres del Colesterol/sangre , Enfermedad Coronaria/etiología , Prevención Primaria , Grasas Insaturadas en la Dieta , Ácidos Grasos Monoinsaturados , Factores de Riesgo , Enfermedad Coronaria/prevención & control , Enfermedad Coronaria/sangre , Ácidos Grasos InsaturadosRESUMEN
Patients with coronary artery diseases are advised to augment their dietary linoleic acid intakes at the expense of saturated fatty acids. We investigated whether the dietary linoleic acid intake of 57 patients with coronary artery disease (47 males, 10 females; ages 61 ñ 10 years) in Curacao is higher as compared with 77 controls (51 males, 26 females; ages 56 ñ 7 years). For this, we measured plasma cholesterol ester fatty acids, which reflect the dietary fatty acid composition of the preceeding weeks. Patients with coronary artery disease and controls had minor differences in cholesterol ester fatty acids. Their cholesterol ester linoleic acid content suggests that the dietary polyunsaturated/saturated fatty acid ratio is far below 1. Comparison with data reported for the the Netherlands, Greenland and Crete showed that the dietary fatty acid composition in Curacao is typically Western with a high intake of saturated fatty acids, a low intake of monounsaturated fatty acids and the consumption of linoleic acid as the predominant polyunsaturated fatty acid. Intake of long chain polyunsaturated fatty acids from fatty fish is low. Reduction of dietary saturated fatty acids, augmentation of fish consumption, and an increase of the O-linolenic/linoleic acid ratio are likely to be of benefit to both primary and secondary prevention from coronary artery disease in Curaco.(AU)
Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adolescente , Enfermedad Coronaria/etiología , Ésteres del Colesterol/sangre , Grasas de la Dieta/sangre , Prevención Primaria , Enfermedad Coronaria/sangre , Enfermedad Coronaria/prevención & control , Grasas Insaturadas en la Dieta , Ácidos Grasos Monoinsaturados , Ácidos Grasos Insaturados , Conducta Alimentaria , Factores de RiesgoRESUMEN
To study the effect on plasma 25-hydroxycholecalciferol (25(OH)D), 1,25-dihydroxycholecalciferol (1,25(OH)2D) and parathyroid hormone (PTH) we supplemented premenopausal (aged 30 (SD 7) years) and postmenopausal (aged 61 (SD 2) years) white women living in The Netherlands in late winter/early spring, and elderly black and white women (aged 75 (SD 6) years) living in Curaçao (Dutch Antilles) with either 10 or 20 micrograms cholecalciferol/d for 4, 5 and 9 weeks respectively. Baseline plasma 25(OH)D concentration of Dutch women was lower than that of Curaçao women. Postmenopausal Dutch women had a higher PTH concentration in plasma than premenopausal Dutch and postmenopausal Curaçao women. There were no differences in plasma 1,25(OH)2D. Cholecalciferol administration increased 25(OH)D in all groups, 1,25(OH)2D in postmenopausal Curaçao women and PTH in postmenopausal Curaçao women and premenopausal Dutch women. Serum and urinary Ca and phosphate concentrations did not change. There were no response differences between 10 and 20 microgram doses. Oral cholecalciferol administration (either 10 or 20 micrograms/d) to women living at northern latitudes in late winter/early spring increased 25(OH)D levels to the baseline levels of elderly people living in the tropics.
Asunto(s)
Colecalciferol/administración & dosificación , Colecalciferol/sangre , Hormona Paratiroidea/sangre , Posmenopausia/sangre , Estaciones del Año , Clima Tropical , Administración Oral , Adulto , Anciano , Anciano de 80 o más Años , Calcifediol/sangre , Calcitriol/sangre , Femenino , Humanos , Persona de Mediana Edad , Países Bajos , Antillas Holandesas , Premenopausia/sangreRESUMEN
Pre- and post-menopausal white women living in The Netherlands in late winter/early spring and black and white post-menopausal women living in Curacao were supplemented with either 400,800 and 2x400 IU vitamin D (3)/day or placebo for 4, 5, or 9 weeks. Baseline plasma 25-hydroxyvitamin D [25(OH)D] of Dutch women was lower than that of Curacao women. Post-menopausal Dutch women had higher parathyroid hormone (PTH) than pre-menopausal Dutch and post-menopausal Curacao women. There were no differences in 1,25-dihydroxyvitamin D [1,25(OH)2D]. Vitamin D supplementation increased 25(OH)D levels in all groups, PTH and 1,25(OH)2D in post-menopausal Curacao women, and PTH in pre-menopausal Dutch women. Serum and urinary calcium and phosphate did not change. There were no response differences between 400 and 800 IU daily doses, or 800 and 2x400 IU doses. Oral vitamin D supplementation raises late winter/early spring plasma 25(OH)D of women living at high latitudes to baseline levels encountered in the tropics (AU)