Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Más filtros











Base de datos
Intervalo de año de publicación
1.
J Public Health Dent ; 60(3): 182-8, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-11109216

RESUMEN

OBJECTIVES: Modeling new biomedical technologies and determining their expected cost is necessary before initiating formal clinical trials. This paper estimates an economic model for the potential cost impact of microbiological screening of toddlers for caries risk compared to the traditional method of managing pediatric caries. METHODS: Potential cost savings were calculated based on screening test properties (sensitivity and specificity) derived from a population of 1,180 children aged 1 to 3 years with a caries prevalence of 15 percent. An algorithm was then developed to allocate prevalent and anticipate incident caries, treatment effectiveness assumptions, and existing regional treatment costs. RESULTS: The cost analysis model conservatively predicts savings of 7.3 percent from screening and early intervention. Cumulative dental treatment costs for a child at age 4 years are $367.90 if the child has been screened and $396.70 otherwise. The model further predicts that cost savings increase significantly as caries prevalence increases. CONCLUSIONS: Microbiologic risk assessment for pediatric caries may be an example of a preventive public health screening technique that results in both clinical benefits and cost savings. If the model is validated by randomized clinical trials, microbiologic screening could be used by pediatric primary care providers to identify toddlers who require early referral to dentists for further risk assessment and early caries management.


Asunto(s)
Bacterias/crecimiento & desarrollo , Atención Dental para Niños/economía , Susceptibilidad a Caries Dentarias , Caries Dental/microbiología , Tamizaje Masivo/economía , Modelos Económicos , Medición de Riesgo , Algoritmos , Preescolar , Ahorro de Costo , Costos y Análisis de Costo , Índice CPO , Caries Dental/prevención & control , Caries Dental/terapia , Predicción , Necesidades y Demandas de Servicios de Salud , Humanos , Lactante , Prevalencia , Sensibilidad y Especificidad , Resultado del Tratamiento
2.
Ann Pharm Fr ; 47(5): 296-303, 1989.
Artículo en Francés | MEDLINE | ID: mdl-2637649

RESUMEN

The synthesis of 7 new 2-[(2-alkoxy-3-methoxyphenyl) methyl]-5-arylamino-1,3,4 oxadiazoles by cyclisation of the corresponding thiosemicarbazides is described. Some of these were tested for anticonvulsant activity. The compound 2-[(2-butoxy-3-methoxy phenyl) methyl]-5-phenylamino 1,3,4-oxadiazole has shown significant anticonvulsant potency. A few new 3-phenyl-5-[(2-alkoxy-3-methoxy phenyl) methyl]-1H-1,2,4 triazoles have also been synthesized.


Asunto(s)
Anticonvulsivantes/síntesis química , Oxadiazoles/farmacología , Triazoles/farmacología , Animales , Masculino , Ratones , Oxadiazoles/síntesis química , Triazoles/síntesis química
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA