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1.
Behav Brain Res ; 173(2): 282-7, 2006 Oct 16.
Artículo en Inglés | MEDLINE | ID: mdl-16887204

RESUMEN

Methyl-beta-carboline-3-carboxylate (or beta-CCM) is a benzodiazepine receptor ligand with inverse agonist properties. Two strains of mice were selected, one for sensitivity (BS) and one for resistance (BR) to a convulsive dose of beta-CCM. These two strains were then shown to differ in several biochemical, pharmacological and behavioral characteristics; specifically BS mice were less anxious than BR mice. The present work provides evidence of differences in the learning abilities of the two strains. Three different learning tasks were used: spatial delayed discrimination on the 4-hole board, a learned choice between a lit and a dark compartment in a T-maze, and place-learning in an 8-arm radial maze. In all three tasks, BS mice had consistently better performance levels than BR mice.


Asunto(s)
Carbolinas/farmacología , Convulsivantes/farmacología , Aprendizaje Discriminativo/efectos de los fármacos , Memoria/efectos de los fármacos , Animales , Animales Recién Nacidos , Conducta Animal , Conducta de Elección/efectos de los fármacos , Femenino , Masculino , Aprendizaje por Laberinto/efectos de los fármacos , Memoria/fisiología , Ratones , Tiempo de Reacción/efectos de los fármacos
2.
Pharmacol Biochem Behav ; 83(1): 1-8, 2006 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-16439006

RESUMEN

The original aims of our study were to investigate the dose-effect relationship of modafinil administration on working memory performance, in parallel with the measurement of plasma corticosterone in chronically-stressed mice, as compared to control mice. Memory performance was evaluated by spontaneous alternation in a T-maze. Vehicle or modafinil (8, 16 or 32 mg/kg) were administered after or without chronic stress (immobilization and exposure to light) for 15 min/day over a period of consecutive 14 days. Immediately after behavioral testing, blood was sampled to measure plasma corticosterone levels. Under non-stress conditions, corticosterone significantly increased with 16 and 32 mg/kg modafinil administration. Interestingly, optimal working memory performance was revealed at the 16 mg/kg dose. Moreover, no correlation was evidenced between working memory performance and plasma corticosterone level in modafinil-treated animals. Under stress conditions, corticosterone level was lowered at 8 mg/kg and remained unchanged at 16 and 32 mg/kg modafinil. An optimal working memory performance was evidenced at 8 mg/kg, which indicated a decrease in the efficiency threshold of modafinil under stress. Furthermore, an inverse correlation emerged between working memory performance and corticosterone level. Our study evidenced for the first time the interaction between stress and memory, in the emotional modulation of working memory performance, as a function of the administered dose of modafinil.


Asunto(s)
Compuestos de Bencidrilo/farmacología , Estimulantes del Sistema Nervioso Central/farmacología , Corticosterona/sangre , Memoria a Corto Plazo/efectos de los fármacos , Estrés Psicológico/sangre , Estrés Psicológico/psicología , Animales , Enfermedad Crónica , Relación Dosis-Respuesta a Droga , Masculino , Ratones , Ratones Endogámicos C57BL , Modafinilo , Actividad Motora/efectos de los fármacos
3.
Pharmacol Biochem Behav ; 73(3): 723-8, 2002 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-12151049

RESUMEN

This study was aimed at determining the effects of a chronic modafinil intraperitoneal administration on the rate of learning in a series of five serial spatial discrimination reversals (SSDR) in a T-maze. Results showed that a daily modafinil administration at 64 mg/kg but not at 32 mg/kg induced a faster learning rate as compared to controls. This learning improvement in experimental mice was due to the faster emergence of a win-stay rule over days of testing. In contrast, a second experiment showed that the same modafinil treatment had no significant effect on contingently reinforced alternation rates over five successive days of testing, as compared to controls. Thus, the results show that modafinil spared the ability to shift responses over trials and consequently, that the use of the win-stay rule to solve the SSDR task observed in modafinil-treated animals is due to an improvement of learning processes.


Asunto(s)
Compuestos de Bencidrilo/farmacología , Estimulantes del Sistema Nervioso Central/farmacología , Aprendizaje/efectos de los fármacos , Animales , Aprendizaje Discriminativo/efectos de los fármacos , Masculino , Aprendizaje por Laberinto/efectos de los fármacos , Memoria/efectos de los fármacos , Ratones , Ratones Endogámicos C57BL , Modafinilo , Desempeño Psicomotor/efectos de los fármacos , Esquema de Refuerzo , Percepción Espacial/efectos de los fármacos
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