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BACKGROUND: Hypersensitivity reactions to toothpastes are rare. The objective of this study was to present the authors' clinical cases in the past 10 years and perform a scoping review of gingival hypersensitivity responses to toothpastes. TYPES OF STUDIES REVIEWED: The authors reviewed records of documented gingival hypersensitivity reactions to dentifrices at the Postgraduate Clinic of Oral Medicine, Complutense University, Madrid, Spain, from January 2013 through December 2022. Furthermore, the authors conducted a search in PubMed with no date limit for articles reporting these hypersensitivity responses up through October 18, 2023. RESULTS: Eleven cases were collected from the clinic. Eight gingival hypersensitivity reactions occurred in women, and 6 were associated with cinnamon. The most frequent lesions diagnosed were red gingiva. The discontinuation of the toothpaste led to the disappearance of the lesions. The search yielded 643 references. Thirteen articles were included in the scoping review, all of them case series and case reports, reporting 32 cases. Lesions affected middle-aged women most frequently, the most common hypersensitivity reaction was gingival redness, and the cases implicated toothpastes containing cinnamon and herbal composition. PRACTICAL IMPLICATIONS: This study provides clues for diagnosing and treating hypersensitivity reactions to toothpastes, which may improve the identification, management, and reporting of these cases.

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INTRODUCTION: Mammary analogue secretory carcinoma (MASC) is a recent discovered entity of salivary glands tumors, reported for first time in 2010. The presence of a translocation encodes the ETS variant transcription factor 6-neurotrophic tyrosine receptor kinase (ETV6-NTRK3) gene fusion differences MASC from other tumors. CASE PRESENTATION: A 68-year-old male showed a non-painful right parotid enlargement, came from dermatology service, and followed by some facial squamous cell carcinomas. A computed tomography (CT) scan showed a 1.7×1.6 cm right parotid enlargement in superficial lobe. The patient underwent a right superficial parotidectomy. The final pathology confirmed the presence of ETV6-NTRK3-positive MASC. Complete right deep parotidectomy and functional cervical emptying were performed. DISCUSSIONS AND CONCLUSIONS: It is necessary to establish an appropriated differential diagnosis between salivary gland tumors. MASC is a low-grade malignancy cancer that sometimes can evolve to a high-grade tumor that might produce local and distance dissemination. Most times, these tumors are only treated by surgical resection and evaluating by a multidisciplinary team the need of more treatments. In our case, the patient showed a primary parotid tumor, removed surgically with free edges, and being identified as MASC. We decided to underwent neck dissection and discovered a second MASC focus on cervical salivary gland; however, there was no nodal dissemination. The patient remains disease-free after 14 months from last surgery. It is important to keep studying genetic therapy targets to ETV6-NTRK3 to obtain a new therapy line to treat those cases that require.

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Objetivo: Determinar el perfil epidemiológico de los donadores de dientes humanos extraídos en establecimientos de salud pública, ubicados en la Paz, San Vicente y La Libertad en el año 2019. Metodología: La investigación fue de tipo descriptiva, transversal y observacional, dirigida a una población de 250 usuarios pertenecientes a 5 UCSF, de ambos sexos, residentes de área rural o urbano con opción única de tratamiento: extracción dental. El paso de instrumentos tuvo lugar en el período de abril a julio del año 2019, buscando caracterizar tanto al donador, como al órgano dental. Resultados: La mayoría de los donadores fueron del sexo femenino (61.6%), en el rango de edad entre 41 a 50 años (21.2%), siendo la residencia rural la más predominante (53.2%). En los indicadores clínicos bucales examinados se encontró que el 50.4% presentaron hábitos deletéreos, con un índice ISHO regular (32.8%), la condición bucal más frecuente encontrada fue caries dental (97%); siendo diabetes la condición sistémica más recurrente (16.8%) y caries dental y secuelas la causa principal de extracción (57.6%). Los órganos dentales con mayor frecuencia de extracción fueron los dientes 4-6 y 3-6 (7.2%). Conclusión: El perfil epidemiológico más frecuente en donadores de dientes humanos extraídos durante el estudio resultó ser el sexo femenino, en edades de 41 a 50 años, con residencia en el área rural, siendo diabetes la condición sistémica más recurrente y caries dental y secuelas, la causa de extracción más frecuente.

Objective: To determine the epidemiological profile of human tooth donors extracted in public health facilities, located in La Paz, San Vicente, and La Libertad in 2019. Methodology: The research was descriptive, transversal and observational, aimed at a population of 250 users belonging to 5 UCSF, of both sexes, residents of rural or urban area with unique treatment option: tooth extraction. The data collection using the instruments took place in the period from April to July 2019, seeking to characterize both the donor and the dental organ. Results: Most donors were female (61.6%), in the age range between 41 and 50 years (21.2%), the most prevalent with rural residence (53.2%). In the oral clinical indicators examined, 50.4% had deleterious habits, with a regular ISHO index (32.8%), the most common oral condition found was tooth decay (97%); diabetes being the most recurrent systemic condition (16.8%) tooth decay and sequelae the leading cause of extraction (57.6%). The most frequent dental organs of removal were teeth 4-6 and 3-6 (7.2%). Conclusion: The most common epidemiological profile in human tooth donors extracted during the study turned out to be female, ages 41 to 50 years, residing in rural areas, with diabetes being the most recurrent systemic condition and tooth decay and sequelae, the most common cause of extraction.

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Objetivo: Identificar y describir alteraciones de voz, habla y deglución en pacientes con síndrome de Sjögren (SS). Material y métodos: Estudio prospectivo, descriptivo, transversal, observacional. Pacientes con SS fueron interrogados y explorados físicamente, realizamos además nasofibrolaringoendoscopia, videolaringoestroboscopia, evaluación fibroendoscópica de la deglución y análisis espectrográfico computarizado de voz y habla (software PRAAT®). Resultados: Incluimos 31 pacientes (96,7% mujeres), tiempo de evolución promedio 5 años 8meses, edad promedio 48,4 años. El SS en 87% secundario, en 13% primario. Sintomatología: 70,9% disfagia, 41,9% disfonía, 35,4% disglosias, 3,2% disartria. Encontramos principalmente alteraciones en: uno o más pares craneales (V, VII, IX, X, XII) (67,7%), mucosa nasofaringolaríngea (77,4%), ondulación de la mucosa alterada en cuerdas vocales (90%), mecanismo de la deglución (90,3%), espectrograma de vocales /e/ (58,06%), /i/ (51,61%) y ritmo del trisílabo «pataka» (35,48%). Conclusiones: El SS presenta alteraciones en voz, habla y deglución, quizá no sólo asociadas axerosis, sino también a trastornos neurológicos probablemente secundarios al síndrome (AU)

Objective: To identify and describe voice, speech and swallowing abnormalities in patients with Sjögren’s Syndrome (SS). Materials and methods: This was a prospective cross-sectional descriptive observational study. Patients with SS were interviewed and physically explored. Nasolaryngeal endoscopy, videolaryngeal stroboscopy, fiberoptic endoscopic evaluation of swallowing and computerized voice spectrographic analysis (PRAAT® software) of voice and speech were also performed. Results: We included 31 patients (96.7% women). Average time of evolution was 5 years; mean age was 48.4 years. Of these SS cases, 87% were secondary and 13% primary. Symptomatology: 70.9% dysphagia, 41.9% dysphonia, 35.4% dysglossia, 3.2% dysarthria. We found abnormalities principally in: one or more cranial nerves (V, VII, IX, X, XII) (67.7%), nasopharyngolaryngeal mucosa (77.4%), mucosal wave of vocal cords (90%), swallowing mechanism (90.3%), spectrogram of the vowels /e/ (58.06%) and /i/ (51.61%), and rhythm of the trisyllable ‘‘pataka’’(35.48%). Conclusions: Patients with SS have voice, speech and swallowing abnormalities, not only associated to xerosis, but perhaps also to neurological abnormalities, probably secondary to the syndrome (AU)

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OBJECTIVE: To identify and describe voice, speech and swallowing abnormalities in patients with Sjögren's Syndrome (SS). MATERIALS AND METHODS: This was a prospective cross-sectional descriptive observational study. Patients with SS were interviewed and physically explored. Nasolaryngeal endoscopy, video laryngeal stroboscopy, fiberoptic endoscopic evaluation of swallowing and computerized voice spectrographic analysis (PRAAT® software) of voice and speech were also performed. RESULTS: We included 31 patients (96.7% women). Average time of evolution was 5 years; mean age was 48.4 years. Of these SS cases, 87% were secondary and 13% primary. Symptomatology: 70.9% dysphagia, 41.9% dysphonia, 35.4% dysglossia, 3.2% dysarthria. We found abnormalities principally in: one or more cranial nerves (V, VII, IX, X, XII) (67.7%), nasopharyngolaryngeal mucosa (77.4%), mucosal wave of vocal cords (90%), swallowing mechanism (90.3%), spectrogram of the vowels /e/ (58.06%) and /i/ (51.61%), and rhythm of the trisyllable "pataka" (35.48%). CONCLUSIONS: Patients with SS have voice, speech and swallowing abnormalities, not only associated to xerosis, but perhaps also to neurological abnormalities, probably secondary to the syndrome.

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O abscesso da mama foi avaliado em 32 pacientes que procuraram o Serviço de Ginecolofia e Obstetrícia em 1990 e 1991. A idade média das pacientes era de 27 anos e 78 por cento delas eram puérperas. O Staphylococcus aureus foi o agente etiológico mais encontrado (90,64 por cento). A penicilina (89,6 por cento) e a ampicilina (75,8 por cento) apresentaram alta resistência. A eritromicina (89,6 por cento), a oxacilina (96,5 por cento), a cefalotina (96,5 por cento), a lincomicina (76,5 por cento), a vancomicina (100 por cento) e o sulfametoxazol-trimetoprim (89,6 por cento) apresentaram alta sensibilidade.

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