RESUMEN
The 70th anniversary of the publication of the double helix model for the structure of deoxyribonucleic acid has oppened the opportunity for reflections and to debate the specific role of each of the original protagonists. Here we review how this discovery has lead to our current medical knowledge and practice, and discuss what we think were the actual contributions of each of these scientists.
El 70 aniversario de la publicación del modelo de doble hélice para la estructura del ácido desoxirribonucleico abre la oportunidad de reflexionar y debatir el papel específico de cada uno de los protagonistas originales. Aquí revisamos las consecuencias de este descubrimiento en nuestro conocimiento y práctica médica actuales, y discutimos lo que creemos que fueron las contribuciones reales de cada uno de estos científicos.
Asunto(s)
Biología , ADN , Medicina , Humanos , Aniversarios y Eventos Especiales , ADN/química , Conocimiento , Conformación de Ácido NucleicoRESUMEN
Debaryomyces hansenii is a spoilage yeast able to grow in a variety of ecological niches, from seawater to dairy products. Results presented in this article show that (i) D. hansenii has an inherent resistance to H2O2 which could be attributed to the fact that this yeast has a basal catalase activity which is several-fold higher than that observed in Saccharomyces cerevisiae under the same culture conditions, (ii) D. hansenii has two genes (DhCTA1 and DhCTT1) encoding two catalase isozymes with a differential enzymatic activity profile which is not strictly correlated with a differential expression profile of the encoding genes.