RESUMEN
Local injection of verapamil into ventrolateral region of the medulla oblongata triggered the release of epinephrine. Verapamil increased the total content of norepinephrine and epinephrine by 560% and decreased the content of serotonin by 46%. Verapamil had no effect on norepinephrine/epinephrine and norepinephrine/(norepinephrine+epinephrine) ratios in normal rats. Blockade of K+-channels in the medulla oblongata by local injection of 0.001 mg amiodarone did not change the levels of epinephrine and norepinephrine and norepinephrine/epinephrine and norepinephrine/(norepinephrine+epinephrine) ratios. In the medulla oblongata, verapamil proportionally increased the levels of norepinephrine, dopamine, and L-DOPA. Similarly, amiodarone increased the levels of L-DOPA and dopamine by 2.6 and 3.2 times, respectively. Amiodarone shifted the ratio of neuroactive amino acids towards inhibitory transmitters.
Asunto(s)
Glándulas Suprarrenales/metabolismo , Amiodarona/farmacología , Antagonistas de Aminoácidos Excitadores/metabolismo , Aminoácidos Excitadores/metabolismo , Bulbo Raquídeo/metabolismo , Sistema Nervioso Simpático/metabolismo , Verapamilo/farmacología , Glándulas Suprarrenales/efectos de los fármacos , Animales , Bloqueadores de los Canales de Calcio/farmacología , Dopamina/metabolismo , Epinefrina/metabolismo , Levodopa/metabolismo , Masculino , Microinyecciones , Norepinefrina/metabolismo , Bloqueadores de los Canales de Potasio/farmacología , Distribución Aleatoria , Ratas , Ratas Endogámicas , Serotonina/metabolismo , Sistema Nervioso Simpático/efectos de los fármacosRESUMEN
It is proposed to make a qualitative analysis of one of the most frequent bronchopulmonary symptoms--cough. This involves dynamic tussographic evaluation of the cough and expectoration in the original inulin test. The analysis covered such cough characteristics as resistance, efficacy, intensity, volleys assessed in patients with lung cancer, chronic bronchitis, tracheobronchial dyskinesia. Typical changes in the above indices observed in each of the patient groups have been defined which are essential for diagnosis and differential diagnosis.
Asunto(s)
Tos/diagnóstico , Enfermedades Pulmonares Obstructivas/diagnóstico , Bronquitis/complicaciones , Bronquitis/diagnóstico , Tos/etiología , Diagnóstico Diferencial , Diseño de Equipo , Femenino , Humanos , Enfermedades Pulmonares Obstructivas/complicaciones , Neoplasias Pulmonares/complicaciones , Neoplasias Pulmonares/diagnóstico , Masculino , Persona de Mediana Edad , Pruebas de Función Respiratoria/instrumentación , Pruebas de Función Respiratoria/métodos , Insuficiencia Respiratoria/complicaciones , Insuficiencia Respiratoria/diagnósticoRESUMEN
The paper describes the basic circuit of a tussograph, a device that monitors cough in patients with bronchopulmonary diseases. An NKT-I makes it possible to calculate the number of tussive expulsions, total and peak expulsions, as well as to record their time distribution. The device may be useful in the study into the efficacy of new antitussive drugs and the assessment of cough clearance. It can provide an insight into mucociliary clearance.