RESUMEN
In patients with ischemic heart disease, the administration of contrast agents iodixanol, ioversol and gadobutrol improves (due to the effect of dilution) the aggregation of erythrocytes in vivo, but does not change their deformation ability and the percentage of different morphological forms of erythrocytes (discocytes and ehinocytes) in the blood. The effect of gadobutrol on the aggregation of erythrocytes is characterized by more expressed antiaggregant effect due special molecular properties of this drug.
Asunto(s)
Medios de Contraste/administración & dosificación , Agregación Eritrocitaria/efectos de los fármacos , Deformación Eritrocítica/efectos de los fármacos , Eritrocitos/metabolismo , Isquemia Miocárdica/sangre , Compuestos Organometálicos/administración & dosificación , Ácidos Triyodobenzoicos/administración & dosificación , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Isquemia Miocárdica/diagnóstico por imagen , RadiografíaRESUMEN
It is established that the x-ray contrast agents urografin (76 %), omnipaque-300, optiray-350, ultravist-300, and visipaque-270 produce a dose-dependent decrease in the deformation properties of human erythrocytes in vitro. The degree of manifestation of this negative influence increases with the osmotic activity of agents in the following order: visipaque = ultravist < or = omnipaque < or = optiray < urografin. The effect of these x-ray contrast agents on the deformation of erythrocytes is reversible. Erythrocytes restore their normal deformation properties upon removal of the osmotic pressure induced by the x-ray contrast agents.
Asunto(s)
Medios de Contraste/farmacología , Deformación Eritrocítica/efectos de los fármacos , Eritrocitos/citología , Adulto , Anciano , Anciano de 80 o más Años , Medios de Contraste/efectos adversos , Relación Dosis-Respuesta a Droga , Femenino , Humanos , Masculino , Persona de Mediana Edad , ÓsmosisRESUMEN
It is shown that Ultravist makes it possible to receive clear visualization of vessel channel in the zone "of interest" without changing functional conditions of heart vascular system and biochemical blood parameters (level of erythrocytes, bilirubine, urine nitrogen, activity of aspartataminotransferase). In concentration 30 mg/ml in vitro and in vivo Ultravist decreases a viscosity limit not affecting other rheological properties of blood. A mechanism of the found Ultravist effect and prospects of its application in practice for children are considered.
Asunto(s)
Angiografía/métodos , Viscosidad Sanguínea/efectos de los fármacos , Sangre/efectos de los fármacos , Medios de Contraste/farmacología , Yohexol/análogos & derivados , Adolescente , Sangre/metabolismo , Niño , Preescolar , Humanos , Lactante , Yohexol/farmacologíaRESUMEN
The effects of X-ray contrast agents on human blood rheology were investigated. The main cause of rheological effects of X-ray contrast media is their action on the structure and function of erythrocytes. There was a relationship between the physicochemical properties and the mechanism of action. The major active factor is the high osmolality of X-ray contrast media solutions. Lipid solubility, specific features of molecular structures and the composition of a dosage form played a definite role.
Asunto(s)
Viscosidad Sanguínea/efectos de los fármacos , Medios de Contraste/farmacología , Adolescente , Adulto , Fenómenos Químicos , Química Física , Medios de Contraste/química , Agregación Eritrocitaria/efectos de los fármacos , Deformación Eritrocítica/efectos de los fármacos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estadísticas no ParamétricasRESUMEN
It was shown that bilignost, in contrast to triombrast, iodamide and metrizamide precipitates spontaneous hemolysis of human erythrocytes. The hemolytic effect of bilignost may be decreased by means of pipolphen and prednisolone or by using the mixture of albumin + glycerin + sodium chloride + bilignost.
Asunto(s)
Medios de Contraste/farmacología , Hemólisis/efectos de los fármacos , Adolescente , Adulto , Células Cultivadas/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Using the ectacytometric method the authors observed that the contrast agents: bilimin, triombrast 76%, iodamide-380, bilignost 20%, bilignost 50%, metrizamide decrease red cell deformability. This effect of the contrast agents depends on their osmolality and chemical structure.