1.
Experientia
; 36(4): 389-91, 1980 Apr 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-7379909
RESUMEN
The content of blood in bone homogenates can be determined quantitatively by estimation of the haemin in the homogenate and in a sample of peripheral blood taken at the same time. Haem is completely split from the haemoglobin molecule by reaction with hydrochloric acid-acetone and converted to haemin, which can be analyzed spectrophotometrically. The blood content can be calculated from the amount of haemin in the homogenate in relation to that of the peripheral blood. This method is useful to determine the real amount of drugs in bone tissue.