RESUMEN
The authors describe a family living in the Dagestan where three relative sibs, girls, suffered from familial spastic paraplegia. The variety described is marked by early debut, pronounced intrafamilial polymorphism of the disease course, autosomal recessive type of inheritance which, according to the reported data, is marked by frequently occurring combination with damage to other organs and systems (the familial spastic paraplegia "plus"). The "pure" disease variety seen in autosomal recessive type of inheritance, detection of the disease symptoms since the birth indicate that the case in question is a rare clinical variety of familial spastic paraplegia.
Asunto(s)
Aberraciones Cromosómicas/diagnóstico , Paraplejía Espástica Hereditaria/diagnóstico , Niño , Preescolar , Aberraciones Cromosómicas/etiología , Aberraciones Cromosómicas/genética , Trastornos de los Cromosomas , Femenino , Genes Recesivos/genética , Humanos , Espasticidad Muscular/diagnóstico , Espasticidad Muscular/etiología , Espasticidad Muscular/genética , Linaje , Paraplejía Espástica Hereditaria/etiología , Paraplejía Espástica Hereditaria/genéticaAsunto(s)
Duramadre/trasplante , Factores de Edad , Animales , Citotoxicidad Inmunológica , Perros , Duramadre/embriología , Duramadre/inmunología , Femenino , Edad Gestacional , Humanos , Hipersensibilidad Tardía/etiología , Sueros Inmunes/inmunología , Ganglios Linfáticos/citología , Embarazo , Conservación de TejidoRESUMEN
Measures aimed at the prevention of complications gain foremost importance when timely surgical treatment of a penetrating craniocerebral wound cannot be conducted. Experimental research and clinical experience have shown that the administration of 50 000--100 000 U of an antibiotic (kanamycin, monomycin, hectamycin, chloramphenicol) into the wound soon after an open penetrating injury had been inflicted to the skull and brain protects the wound from microbial contamination. This provides the possibility for postponing the plastic operation of the defect in the dura mater.