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1.
Rev Gastroenterol Mex (Engl Ed) ; 86(4): 348-355, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34272192

RESUMEN

INTRODUCTION AND AIMS: The adenoma detection rate (ADR) is the most important quality indicator for the prevention of colorectal cancer but serrated polyps are also precursor lesions of the disease. The aim of our study was to compare the detection rate of proximal serrated polyps (PSPs) and that of clinically significant serrated polyps (CSSPs) between endoscopists and analyze the relation of those parameters to the ADR. METHODS: An observational, prospective, cross-sectional study was conducted on all patients that underwent colonoscopy at the Policlínico Peruano Japonés within the time frame of July 2015 and August 2016. The ADR and PSP and CSSP detection rates between endoscopists were compared through multivariate logistic regression and the association between those parameters was calculated through the Pearson correlation coefficient. RESULTS: The study included 15 endoscopists and 1,378 colonoscopies. The PSP detection rate ranged from 1.8-17% between endoscopists and had an almost perfect correlation with the CSSP detection rate (p = 0.922), as well as strongly correlating with the ADR (p = 0.769). CONCLUSIONS: There was great variability in the PSP detection rate between endoscopists. It also had an almost perfect correlation with the CSSP detection rate and strongly correlated with the ADR. Those results suggest a high CSSP miss rate at endoscopy and a low PSP detection rate.


Asunto(s)
Pólipos del Colon , Neoplasias Colorrectales , Pólipos del Colon/diagnóstico , Colonoscopía , Neoplasias Colorrectales/diagnóstico , Estudios Transversales , Humanos , Estudios Prospectivos
2.
Artículo en Inglés, Español | MEDLINE | ID: mdl-32868136

RESUMEN

INTRODUCTION AND AIMS: The adenoma detection rate (ADR) is the most important quality indicator for the prevention of colorectal cancer but serrated polyps are also precursor lesions of the disease. The aim of our study was to compare the detection rate of proximal serrated polyps (PSPs) and that of clinically significant serrated polyps (CSSPs) between endoscopists and analyze the relation of those parameters to the ADR. METHODS: An observational, prospective, cross-sectional study was conducted on all patients that underwent colonoscopy at the Policlínico Peruano Japonés within the time frame of July 2015 and August 2016. The ADR and PSP and CSSP detection rates between endoscopists were compared through multivariate logistic regression and the association between those parameters was calculated through the Pearson correlation coefficient. RESULTS: The study included 15 endoscopists and 1,378 colonoscopies. The PSP detection rate ranged from 1.8-17% between endoscopists and had an almost perfect correlation with the CSSP detection rate (p = 0.922), as well as strongly correlating with the ADR (p = 0.769). CONCLUSIONS: There was great variability in the PSP detection rate between endoscopists. It also had an almost perfect correlation with the CSSP detection rate and strongly correlated with the ADR. Those results suggest a high CSSP miss rate at endoscopy and a low PSP detection rate.

3.
Proc Math Phys Eng Sci ; 474(2220): 20180290, 2018 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-30602926

RESUMEN

A mathematical model formulated as a system of Hamilton-Jacobi equations describes implicitly the propagation of a foam-liquid front in an oil reservoir, as the zero-level set of the solution variable. The conceptual model is based on the 'pressure-driven growth' model in Lagrangian coordinates. The Eulerian mathematical model is solved numerically, where the marching is done via a finite volume scheme with an upwind flux. Periodic reinitialization ensures a more accurate implicit representation of the front. The numerical level set contour values are initially formed to coincide with an early time asymptotic analytical solution of the pressure-driven growth model. Via the simulation of the Eulerian numerical model, numerical data are obtained from which graphical representations are generated for the location of the propagating front, the angle that the front normal makes with respect to the horizontal and the front curvature, all of which are compared with the Lagrangian model predictions. By making this comparison, it is possible to confirm the existence of a concavity in the front shape at small times, which physically corresponds to an abrupt reorientation of the front over a limited length scale.

5.
Rev Gastroenterol Mex ; 80(4): 239-47, 2015.
Artículo en Inglés, Español | MEDLINE | ID: mdl-26253888

RESUMEN

BACKGROUND: Identifying persons at high risk for advanced colorectal neoplasia can aid in the prevention of colon cancer. Previous studies have shown that some patients can present with proximal advanced neoplasia with no distal findings. AIMS: To determine the factors related to advanced neoplasia and advanced proximal colorectal neoplasia in a Latin American population. MATERIAL AND METHODS: A prospective, cross-sectional, observational, analytic study was conducted. It included patients that underwent colonoscopy at the Policlínico Peruano Japonés within the time frame of January and July 2012. Advanced neoplasia was defined as the presence of lesions ≥ 10mm with a villous component, high-grade dysplasia, or carcinoma. The splenic flexure was the limit between the proximal and distal colon. RESULTS: A total of 846 patients were included in the study. Advanced neoplasia was detected in 108 patients (12.8%) and advanced proximal neoplasia in 55 patients (6.7%), 42 (76.4%) of whom had no neoplasia in the distal colon. Factors related to advanced neoplasia found in the multivariate analysis were age, at the intervals of 50-59 (p=0.019), 60-69 (p=0.016), and ≥ 70 years (0.002) and male sex (p=0.003). In the evaluation of advanced proximal neoplasia, the multivariate analysis identified the 60-69 year age interval (p=0.039) and advanced distal neoplasia (p=0.028) as factors related to advanced proximal disease. The ROC curve established the age cut-off point at 60 years for initially performing colonoscopy, rather than sigmoidoscopy. CONCLUSIONS: Age and sex are related to advanced neoplasia, whereas age and advanced distal neoplasia are related to advanced proximal neoplasia.


Asunto(s)
Adenoma/patología , Colon/patología , Neoplasias Colorrectales/patología , Adenoma/diagnóstico por imagen , Adenoma/etiología , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Colonoscopía , Neoplasias Colorrectales/diagnóstico por imagen , Neoplasias Colorrectales/etiología , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Estadificación de Neoplasias , Perú , Estudios Prospectivos , Factores de Riesgo , Factores Sexuales
6.
Histopathology ; 46(4): 374-9, 2005 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-15810948

RESUMEN

OBJECTIVE: To compare the Helicobacter pylori-associated pathology in gastric biopsies taken from patients living at sea level with those taken from patients living at high altitude. METHODS AND RESULTS: We included 38 patients from a hospital in the Andean city of La Oroya, Peru, located at 3700 m in altitude, and 40 control patients taken from Comas Clinic located in the city of Lima at sea level. Fibrepanendoscopy and multiple biopsies were performed in all the patients followed by histopathological examination. In the antrum, patients from the Andean town had a higher prevalence of glandular lymphoid adherence lesions, active germinal centres, moderate to severe chronic atrophic gastritis, intestinal metaplasia and moderate to severe total deep gland loss, than did patients from the coastal town. Furthermore, the severity of the histological lesions seen in the gastric body and cardia was significantly greater in the high-altitude patients than in those from sea level. CONCLUSION: This study suggests that the severity of H. pylori-associated gastric lesions seen on histopathological examination is greater in patients living at high altitude, the cause of which is most probably multifactorial but nonetheless principally altitude related.


Asunto(s)
Altitud , Gastritis/patología , Infecciones por Helicobacter/complicaciones , Adolescente , Adulto , Biopsia , Cardias/microbiología , Cardias/patología , Femenino , Gastritis/complicaciones , Infecciones por Helicobacter/microbiología , Helicobacter pylori/crecimiento & desarrollo , Humanos , Masculino , Persona de Mediana Edad , Perú , Antro Pilórico/microbiología , Antro Pilórico/patología , Índice de Severidad de la Enfermedad
7.
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;35(4): 219-224, 2005. graf, tab
Artículo en Español | BINACIS | ID: bin-123498

RESUMEN

Se ha planteado la posibilidad de una predisposición racial para adquirir la infección del estómago por el Helicobacter pylori. Sin embargo, no se ha tenido en cuenta el nivel socioeconómico de los pacientes. Objetivo: Comparar la prevalencia de la infección por Helicobacter pylori en la población japonesa residente en el Perú y en peruanos nativos, con similares condiciones socioeconómicas. Material y métodos: Estudio prospectivo realizado en el Policlínico Peruano-Japonés (Lima-Perú), donde incluimos a dos grupos de pacientes: japoneses y peruanos nativos con síntomas crónicos del tracto gastrointestinal superior, ambos de nivel socioeconómico medio y alto. Se excluyeron pacientes con úlcera péptica. Para diagnosticar la infección se utilizó la prueba de la ureasa, la Reacción en Cadena de la Polimerasa (PCR) y serología con ELISA IgG. Resultados: Evaluamos 168 pacientes de raza japonesa (edad promedio 54.6±12.62 años, 75% mujeres), y los comparamos con 161 peruanos (edad 42.12±14.48 años, 61.5% mujeres). Utilizando la prueba de la ureasa, la prevalencia de infección por el Helicobacter pylori en peruanos fue de 47.8% y en japoneses de 47.0% (p=0.88). Utilizando PCR, en peruanos fue de 49.7% y en japoneses 43.5% (p=0.28). Conclusiones: En el Perú, las personas de raza y ascendencia japonesa pura comparados con población peruana del mismo estrato social y similar grupo etáreo, tienen similar prevalencia de la infección por el Helicobacter pylori, con lo que podemos postular que en el Perú y en estos grupos étnicos no existe predisposición racial para adquirir la infección.(AU)


Objective: To compare the prevalence of Helicobacter pylori infection in native Peruvians and Japaneses residing in Peru. METHODS: Prospective study carried out at [quot ]Policlinico Peruano-Japonés[quot ] (Lima-Perú). We included Peruvians and Japaneses residing in Peru with chronic symptoms of the upper gastrointestinal tract. Both groups were from medium to high socioeconomic status. We excluded patients with peptic ulcer. PCR, rapid ureasa test and IgG ELISA were used to diagnose the infection. RESULTS: We evaluated 168 Japaneses (mean age 54.6 +/- 12.62 years, 75% female), and 161 Peruvians (mean age of 42.12 +/- 14.48 years, 61.5% female). Using the rapid ureasa test, the prevalence of Helicobacter pylori infection in Peruvians was 47.8%, and in Japaneses 47.0% (p=0.88). Using PCR, in Peruvians was 49.7% and in Japaneses 43.5% (p=0.28). CONCLUSION: Peruvians and Japaneses residing in Peru have a similar prevalence of Helicobacter pylori infection, after controlling factors such as socioeconomic status and age, suggesting that in Peru and in these ethnic groups, there is no racial predisposition to acquire the infection.(AU)


Asunto(s)
Adolescente , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Gastritis/etnología , Infecciones por Helicobacter/etnología , Helicobacter pylori , Gastritis/diagnóstico , Gastritis/microbiología , Infecciones por Helicobacter/diagnóstico , Infecciones por Helicobacter/microbiología , Japón/etnología , Perú/epidemiología , Prevalencia , Estudios Prospectivos , Factores Socioeconómicos
8.
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;35(4): 219-224, 2005. graf, tab
Artículo en Español | LILACS | ID: lil-482211

RESUMEN

Se ha planteado la posibilidad de una predisposición racial para adquirir la infección del estómago por el Helicobacter pylori. Sin embargo, no se ha tenido en cuenta el nivel socioeconómico de los pacientes. Objetivo: Comparar la prevalencia de la infección por Helicobacter pylori en la población japonesa residente en el Perú y en peruanos nativos, con similares condiciones socioeconómicas. Material y métodos: Estudio prospectivo realizado en el Policlínico Peruano-Japonés (Lima-Perú), donde incluimos a dos grupos de pacientes: japoneses y peruanos nativos con síntomas crónicos del tracto gastrointestinal superior, ambos de nivel socioeconómico medio y alto. Se excluyeron pacientes con úlcera péptica. Para diagnosticar la infección se utilizó la prueba de la ureasa, la Reacción en Cadena de la Polimerasa (PCR) y serología con ELISA IgG. Resultados: Evaluamos 168 pacientes de raza japonesa (edad promedio 54.6±12.62 años, 75% mujeres), y los comparamos con 161 peruanos (edad 42.12±14.48 años, 61.5% mujeres). Utilizando la prueba de la ureasa, la prevalencia de infección por el Helicobacter pylori en peruanos fue de 47.8% y en japoneses de 47.0% (p=0.88). Utilizando PCR, en peruanos fue de 49.7% y en japoneses 43.5% (p=0.28). Conclusiones: En el Perú, las personas de raza y ascendencia japonesa pura comparados con población peruana del mismo estrato social y similar grupo etáreo, tienen similar prevalencia de la infección por el Helicobacter pylori, con lo que podemos postular que en el Perú y en estos grupos étnicos no existe predisposición racial para adquirir la infección.


Objective: To compare the prevalence of Helicobacter pylori infection in native Peruvians and Japaneses residing in Peru. METHODS: Prospective study carried out at [quot ]Policlinico Peruano-Japonés[quot ] (Lima-Perú). We included Peruvians and Japaneses residing in Peru with chronic symptoms of the upper gastrointestinal tract. Both groups were from medium to high socioeconomic status. We excluded patients with peptic ulcer. PCR, rapid ureasa test and IgG ELISA were used to diagnose the infection. RESULTS: We evaluated 168 Japaneses (mean age 54.6 +/- 12.62 years, 75% female), and 161 Peruvians (mean age of 42.12 +/- 14.48 years, 61.5% female). Using the rapid ureasa test, the prevalence of Helicobacter pylori infection in Peruvians was 47.8%, and in Japaneses 47.0% (p=0.88). Using PCR, in Peruvians was 49.7% and in Japaneses 43.5% (p=0.28). CONCLUSION: Peruvians and Japaneses residing in Peru have a similar prevalence of Helicobacter pylori infection, after controlling factors such as socioeconomic status and age, suggesting that in Peru and in these ethnic groups, there is no racial predisposition to acquire the infection.


Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto , Persona de Mediana Edad , Anciano , Gastritis/etnología , Helicobacter pylori , Infecciones por Helicobacter/etnología , Estudios Prospectivos , Factores Socioeconómicos , Gastritis/diagnóstico , Gastritis/microbiología , Infecciones por Helicobacter/diagnóstico , Infecciones por Helicobacter/microbiología , Japón/etnología , Perú/epidemiología , Prevalencia
9.
Acta gastroenterol. latinoam ; 33(3): 129-132, Aug. 2003. ilus, tab
Artículo en Inglés | BINACIS | ID: bin-4631

RESUMEN

It has been previously observed that in dyspeptic patients with hunger pain, that is, with pain suggestive of the presence of peptic ulcer, only 12% had an endoscopically demonstrated ulcer, the remaining 88% showing absence of important macroscopically detectable lesions (idiopathic dyspepsia). In order to investigate the possibility of a relationship between hunger pain and some alteration in gastroduodenal motility, the gastric emptying rates of patients presenting idiopathic dyspepsia with and without hunger pain were compared with those of normal control subjects. The study was conducted in 40 patients presenting idiopathic dyspepsia, 20 with and 20 without hunger pain, and 30 voluntary apparently normal control subjects. The patients and the controls ingested, with a standard breakfast, a gelatine capsule containing 10 radioopaque polyurethane markers, and the gastric emptying of the markers was evaluated taking 3 x-ray films of the abdomen at 1.5, 3.0 and 4.5 hours after the breakfast. The gastric emptying rates of the markers were significantly higher in the patients with hunger pain, and significantly lower in the patients without hunger pain, than in the normal control subjects. In idiopathic dyspepsia with and without hunger pain there are, respectively, abnormally increased and abnormally decreased gastric emptying rates of undigestible solid markers. Our findings could help to better understand the pathogenesis of those different types of dyspepsia and, consequently, to improve their treatment. (AU)


Asunto(s)
Persona de Mediana Edad , Humanos , Masculino , Femenino , Adulto , Anciano , Adolescente , Dolor Abdominal/fisiopatología , Dispepsia/fisiopatología , Vaciamiento Gástrico/fisiología , Hambre , Dolor Abdominal/diagnóstico por imagen , Estudios de Casos y Controles , Dispepsia/diagnóstico por imagen , Medios de Contraste
10.
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;33(3): 129-132, Aug. 2003. ilus, tab
Artículo en Inglés | LILACS | ID: lil-362378

RESUMEN

It has been previously observed that in dyspeptic patients with hunger pain, that is, with pain suggestive of the presence of peptic ulcer, only 12% had an endoscopically demonstrated ulcer, the remaining 88% showing absence of important macroscopically detectable lesions (idiopathic dyspepsia). In order to investigate the possibility of a relationship between hunger pain and some alteration in gastroduodenal motility, the gastric emptying rates of patients presenting idiopathic dyspepsia with and without hunger pain were compared with those of normal control subjects. The study was conducted in 40 patients presenting idiopathic dyspepsia, 20 with and 20 without hunger pain, and 30 voluntary apparently normal control subjects. The patients and the controls ingested, with a standard breakfast, a gelatine capsule containing 10 radioopaque polyurethane markers, and the gastric emptying of the markers was evaluated taking 3 x-ray films of the abdomen at 1.5, 3.0 and 4.5 hours after the breakfast. The gastric emptying rates of the markers were significantly higher in the patients with hunger pain, and significantly lower in the patients without hunger pain, than in the normal control subjects. In idiopathic dyspepsia with and without hunger pain there are, respectively, abnormally increased and abnormally decreased gastric emptying rates of undigestible solid markers. Our findings could help to better understand the pathogenesis of those different types of dyspepsia and, consequently, to improve their treatment.


Asunto(s)
Persona de Mediana Edad , Humanos , Masculino , Femenino , Adulto , Adolescente , Dolor Abdominal , Dispepsia , Vaciamiento Gástrico , Hambre , Dolor Abdominal , Estudios de Casos y Controles , Medios de Contraste , Dispepsia
11.
Acta Gastroenterol Latinoam ; 33(3): 129-32, 2003.
Artículo en Inglés | MEDLINE | ID: mdl-14708460

RESUMEN

It has been previously observed that in dyspeptic patients with "hunger pain", that is, with pain suggestive of the presence of peptic ulcer, only 12% had an endoscopically demonstrated ulcer, the remaining 88% showing absence of important macroscopically detectable lesions (idiopathic dyspepsia). In order to investigate the possibility of a relationship between "hunger pain" and some alteration in gastroduodenal motility, the gastric emptying rates of patients presenting idiopathic dyspepsia with and without "hunger pain" were compared with those of normal control subjects. The study was conducted in 40 patients presenting idiopathic dyspepsia, 20 with and 20 without "hunger pain", and 30 voluntary apparently normal control subjects. The patients and the controls ingested, with a standard breakfast, a gelatine capsule containing 10 radioopaque polyurethane markers, and the gastric emptying of the markers was evaluated taking 3 x-ray films of the abdomen at 1.5, 3.0 and 4.5 hours after the breakfast. The gastric emptying rates of the markers were significantly higher in the patients with "hunger pain", and significantly lower in the patients without "hunger pain", than in the normal control subjects. In idiopathic dyspepsia with and without "hunger pain" there are, respectively, abnormally increased and abnormally decreased gastric emptying rates of undigestible solid markers. Our findings could help to better understand the pathogenesis of those different types of dyspepsia and, consequently, to improve their treatment.


Asunto(s)
Dolor Abdominal/fisiopatología , Dispepsia/fisiopatología , Vaciamiento Gástrico/fisiología , Hambre , Dolor Abdominal/diagnóstico por imagen , Adolescente , Adulto , Anciano , Estudios de Casos y Controles , Medios de Contraste , Dispepsia/diagnóstico por imagen , Femenino , Humanos , Masculino , Persona de Mediana Edad , Radiografía
12.
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;33(3): 129-32, 2003.
Artículo en Inglés | BINACIS | ID: bin-38821

RESUMEN

It has been previously observed that in dyspeptic patients with [quot ]hunger pain[quot ], that is, with pain suggestive of the presence of peptic ulcer, only 12


had an endoscopically demonstrated ulcer, the remaining 88


showing absence of important macroscopically detectable lesions (idiopathic dyspepsia). In order to investigate the possibility of a relationship between [quot ]hunger pain[quot ] and some alteration in gastroduodenal motility, the gastric emptying rates of patients presenting idiopathic dyspepsia with and without [quot ]hunger pain[quot ] were compared with those of normal control subjects. The study was conducted in 40 patients presenting idiopathic dyspepsia, 20 with and 20 without [quot ]hunger pain[quot ], and 30 voluntary apparently normal control subjects. The patients and the controls ingested, with a standard breakfast, a gelatine capsule containing 10 radioopaque polyurethane markers, and the gastric emptying of the markers was evaluated taking 3 x-ray films of the abdomen at 1.5, 3.0 and 4.5 hours after the breakfast. The gastric emptying rates of the markers were significantly higher in the patients with [quot ]hunger pain[quot ], and significantly lower in the patients without [quot ]hunger pain[quot ], than in the normal control subjects. In idiopathic dyspepsia with and without [quot ]hunger pain[quot ] there are, respectively, abnormally increased and abnormally decreased gastric emptying rates of undigestible solid markers. Our findings could help to better understand the pathogenesis of those different types of dyspepsia and, consequently, to improve their treatment.

13.
Int J Sports Med ; 22(8): 572-8, 2001 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-11719892

RESUMEN

Blood composition, hemoglobin mass (CO rebreathing method) and VO2peak were measured in 15 untrained (UT-Bogotá) and 14 trained males (TR-Bogotá) living at 2600 m of altitude, and in 14 untrained lowlanders (UT-Berlin). [Hb] amounted to 15.3 + 0.2(SE) g/dl in UT-Berlin, 17.4 + 0.2 g/dl in UT-Bogotá and 16.0 + 0.2 g/dl in TR-Bogotá. Hb mass was significantly higher in UT-Bogotá (13.2 + 0.4 g/kg, P < 0.01) and in TR-Bogotá (14.7 + 0.5 g/kg, P < 0.001) than in UT-Berlin (11.7 + 0.2 g/kg). In TR-Bogotá also plasma volume was expanded. Erythropoietin concentrations in UT-Bogotá and TR-Bogotá were not significantly increased. There was a positive correlation between blood volume and VO2peak for the pooled values of all subjects, if the oxygen uptake of UT-Berlin was corrected for an ascent to 2600 m. For the Hb mass - VO2peak relation two groups are indicated pointing to two types of altitude acclimatization with different Hb mass increases but similar distribution of aerobic performance capacity. We suggest that different genetic properties in a population of mixed ethnic origin might play a role.


Asunto(s)
Aclimatación/fisiología , Eritropoyesis/fisiología , Ejercicio Físico/fisiología , Hemoglobinas/fisiología , Consumo de Oxígeno , Adulto , Altitud , Berlin , Recuento de Células Sanguíneas , Colombia , Volumen de Eritrocitos , Humanos , Masculino , Aptitud Física , Análisis de Regresión
14.
Rev Med Panama ; 26: 13-8, 2001.
Artículo en Español | MEDLINE | ID: mdl-16161718

RESUMEN

BACKGROUND: Although the neurological manifestations of HIV infection occur at any age, children with perinatal AIDS are affected earlier and with greater impact. There are no published data about a potential association between HIV encephalopathy and viral load in THE CSF OF the pediatric population. DESIGN: Twenty-three children, aged 7 months to 10 years, were studied as part of a multicenter international study that evaluated double versus triple antiretroviral therapy. Samples of CSF and plasma were collected for HIV RNA measurements on day 0 and on follow-up weeks 8, 16, and 48. Neurological assessments, psychological evaluations, and CT scans were done on admission and at study end. Viral isolates were processed for genotypic resistance. RESULTS: No correlation between viral load in CSF and plasma was detected at study onset. Eighty percent of children had >2 log HIV RNA in CSF at day 0 but only 30% at week 16. Eight subjects responded favorably to therapy and their CSF had undetectable viral load during follow-up determinations. On day 0, 72% of children had identical patterns of genotypic resistance in CSF and plasma samples. At week 48, however, only 11% of these subjects had identical patterns. On day 0, 83% of children had abnormal neurological findings but these alterations declined to 35% at week 48 (p = 0.004). Most children with neurological abnormalities had detectable CSF viral loads (65% vs 17%, p = 0.04). CONCLUSIONS: The data generated in this study suggest that CSF and plasma behave as two different body compartments in terms of HIV dynamics and resistance mutants. Presence of neurological abnormalities correlate with detection of HIV in CSF and these alterations improve as therapy decreases CSF viral load. These results underscore the importance of using ARV drugs with good CNS penetration for optimal management of HIV-infected young children.


Asunto(s)
Antirretrovirales/uso terapéutico , Infecciones por VIH , Complejo SIDA Demencia/diagnóstico , Complejo SIDA Demencia/tratamiento farmacológico , Complejo SIDA Demencia/virología , Factores de Edad , Antirretrovirales/administración & dosificación , Sangre/virología , Líquido Cefalorraquídeo/virología , Niño , Preescolar , Interpretación Estadística de Datos , Farmacorresistencia Viral/genética , Quimioterapia Combinada , Estudios de Seguimiento , Genotipo , VIH/genética , VIH/aislamiento & purificación , Infecciones por VIH/sangre , Infecciones por VIH/líquido cefalorraquídeo , Infecciones por VIH/tratamiento farmacológico , Infecciones por VIH/virología , Humanos , Lactante , Estudios Multicéntricos como Asunto , Mutación , ARN Viral/sangre , ARN Viral/líquido cefalorraquídeo , Ensayos Clínicos Controlados Aleatorios como Asunto , Factores de Tiempo , Carga Viral
15.
Rev Chil Obstet Ginecol ; 59(4): 280-3, 1994.
Artículo en Español | MEDLINE | ID: mdl-7659824

RESUMEN

The post surgical urinary retention syndrome is a frequent problem after vaginal surgery. In many medical centers it is used a transurethral vesical drainage for three to five days with or without vesical reeducation to prevent it. In order to determine the importance of the time of drainage and vesical reeducation in the presence of this syndrome 106 patients submitted to vaginal surgery were studied at random and prospectively, in our service. Patients were distributed in three groups: the first one, with 37 women in which the drainage was withdrawn at 24 hours; in the second group it was retired at 72 hours and in the third group the drainage was removed at 72 hours with previous vesical reeducation. The results show that those patients who were less time under vesical drainage presented a minor frequency of urinary retention after surgery (24.3% vs 30.7% and 43.7%).


Asunto(s)
Complicaciones Posoperatorias/terapia , Cateterismo Urinario , Retención Urinaria/terapia , Vagina/cirugía , Adulto , Anciano , Catéteres de Permanencia , Femenino , Humanos , Persona de Mediana Edad , Estudios Prospectivos , Infecciones Urinarias/terapia
16.
Acta Gastroenterol Latinoam ; 21(4): 211-9, 1991.
Artículo en Español | MEDLINE | ID: mdl-1824177

RESUMEN

The rate of infection by Helicobacter pylori in peruvian dyspeptic patients (84%) is higher than that reported in symptomatic patients from developed countries. Helicobacter pylori infection did not increase with age. The ecological distribution is similar in the three different geographical regions of Peru. Only women of high economic status had significantly lower rates of Helicobacter pylori infection compared to all other groups. The recurrence rate after treatment is higher than that reported from developed countries.


Asunto(s)
Gastritis/etiología , Infecciones por Helicobacter/epidemiología , Helicobacter pylori , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Altitud , Biopsia , Método Doble Ciego , Endoscopía del Sistema Digestivo , Ensayo de Inmunoadsorción Enzimática , Femenino , Infecciones por Helicobacter/complicaciones , Infecciones por Helicobacter/diagnóstico , Infecciones por Helicobacter/tratamiento farmacológico , Helicobacter pylori/aislamiento & purificación , Humanos , Masculino , Persona de Mediana Edad , Perú/epidemiología , Factores Sexuales , Factores Socioeconómicos , Estómago/patología
17.
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;21(4): 211-9, 1991.
Artículo en Español | BINACIS | ID: bin-51272

RESUMEN

The rate of infection by Helicobacter pylori in peruvian dyspeptic patients (84


) is higher than that reported in symptomatic patients from developed countries. Helicobacter pylori infection did not increase with age. The ecological distribution is similar in the three different geographical regions of Peru. Only women of high economic status had significantly lower rates of Helicobacter pylori infection compared to all other groups. The recurrence rate after treatment is higher than that reported from developed countries.

18.
Rev. psiquiatr. (Santiago de Chile) ; 6(4): 297-303, oct.-dic. 1989. tab
Artículo en Español | LILACS | ID: lil-84694

RESUMEN

Se realiza estudio descriptivo de los desórdenes conversivos en la niñez y adolescencia temprana. Se revisan fichas de 29 niños y adolescentes, 7 varones y 22 niñas hospitalizados entre los años 1982 y 1987 en el Servicio de Salud Mental Infantil del Hospital Roberto del Río. Se estudian diversas variables, como edad, sexo, tipo de síntomas, lapso entre inicio del síntoma y primera consulta, situación desencadenante, repercusión del síntoma, tiempo transcurrido desde la primera consulta a la desaparición del síntoma, sintomatologíaprevia, evolución post-alta, dificultades de rendimiento escolar, dinámica familiar. Se señala que en los síndromes conversivos hay un franco predominio de mujeres respecto a los varones y que en las formas mixtas son más frecuentes respecto a las manifestaciones motoras o sensoriales únicas. La causa desencadenante principal fue de índole relacional. La mayoría de los pacientes pertenecía a familias disfuncionales, siendo más frecuente la disfunción conyugal que la parental y esta disfunción se relacionaba con la iniciación, mantención y muy probablemente con la recaída de las manifestaciones clínicas. Se postula finalmente que el enfoque sistémico constituye una perspectiva promisoria en el estudio de los desórdenes conversivos


Asunto(s)
Niño , Adolescente , Humanos , Masculino , Femenino , Trastornos de Conversión , Chile
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