RESUMEN
BACKGROUND AND OBJECTIVE: Overactive bladder (OAB) is a medical condition characterized by an increase frequency and urgency, with or without urge incontinence. 80% of the world's population presently uses herbal medicine for some aspect of primary health care according to a survey conducted by World Health Organization. The objective of present review was to present an updated, comprehensive and categorized information about medicinal plants used or with potential for the treatment of overactive bladder. METHODS: All relevant literature databases were searched up. The sources of data included Google Scholar, Science Direct, Web of Science and PubMed. The search terms were plant, herb, herbal therapy, phytotherapy, overactive bladder, cystitis and urinary incontinence. RESULTS: Studies on a number of medicinal plants revealed that phytochemials extracted from different plant's part showed protective effect against increased contractile activity of urinary bladder and increased urination frequency, the characteristic manifestations of OAB. Medicinal plant extracts also reduced urinary oxidative stress markers,inflammation and agonist induced bladder contractile response. CONCLUSION: A variety of medicinal plants promise their use in overactive bladder diseases. In addition to the standardization of these medicinal plants, screening plants as anti-overactive bladder agents may help to find new sources of therapy for overactive bladder.
RESUMEN
Myelosuppression or bone marrow suppression is one of the most common side effects caused by anti-cancer drugs. Certain nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics and viruses like B19 virus can also cause bone marrow suppression resulting in serious consequences like leukopenia, anemia and thrombocytopenia. Currently, it is mainly treated by Filgrastim, use of which is not without side effects. Certain natural drugs can be a safer alternative to treat myelosuppression. Azadirachta indica, commonly known as Neem, is an important medicinal plant of subcontinent. Keeping in view the traditional uses of Neem, present study aims to investigate its potential role in reversing myelosuppression. Albino rats were used to determine hematopoietic activity of Neem leaves after inducing myelosuppression by cyclophosphamide given subcutaneously. Filgrastim was used as reference standard to compare the antimyelosuppressant activity of the drug. The drug was evaluated in three doses i.e. 50mg/kg, 100mg/kg and 200mg/kg body weight, while blood samples were drawn on 0, 1st, 7th, 14th and 21st day. The drug was found to be effective in reversing bone marrow suppression in all three doses based on the hematological parameters (mean WBC, RBC, platelets, Hb, Hct etc.) which improved significantly. The results suggest that the drug can be used as antimyelosuppressant after establishing its safety and identifying its active constituents with their mechanism of action.
Asunto(s)
Azadirachta , Enfermedades de la Médula Ósea , Médula Ósea , Fármacos Hematológicos , Hematopoyesis , Extractos Vegetales , Animales , Azadirachta/química , Médula Ósea/efectos de los fármacos , Médula Ósea/metabolismo , Enfermedades de la Médula Ósea/inducido químicamente , Enfermedades de la Médula Ósea/tratamiento farmacológico , Enfermedades de la Médula Ósea/metabolismo , Ciclofosfamida , Modelos Animales de Enfermedad , Filgrastim/farmacología , Fármacos Hematológicos/aislamiento & purificación , Fármacos Hematológicos/farmacología , Hematopoyesis/efectos de los fármacos , Metanol/química , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/farmacología , Hojas de la Planta , Solventes/química , RatasRESUMEN
The liquid and semisolid matrix technology, filling liquids, semi-solids and gels in hard gelatin capsule are promising, thus, there is a need of enhanced research interest in the technology. Therefore, the present study was aimed to investigate isoniazid (freely soluble) and metronidazole (slightly soluble) gels filled in hard gelatin capsules for the effect of poloxamers of different viscosities on release of the drugs. Gel of each drug (10% w/w, particle size 180-250 µm), prepared by mixing poloxamer and 8% w/w hydrophilic silicon dioxide (Aerosil® A200), was assessed for rheology, dispersion stability and release profile. Both the drugs remained dispersed in majority of gels for more than 30 days, and dispersions were depended on gels' viscosity, which was further depended on viscosity of poloxamers. A small change in viscosity was noted in gels on storage. FTIR spectra indicated no interactions between components of the gels. The gels exhibited thixotropic and shear-thinning behaviour, which were suitable for filling in hard gelatin capsules without any leakage from the capsules. The release of both drugs from the phase-stable gels for 30 days followed first-order kinetics and was found to be correlated to drugs' solubility, poloxamers' viscosity, polyoxyethylene contents and proportion of block copolymer (poloxamers) in the gels. The findings of the present study indicated that release of drugs of different solubilities (isoniazid and metronidazole) might be modified from gels using different poloxamers and Aerosil® A200.