RESUMEN
The role of temporal coherence at photodynamic action of light on living cells was investigated. A mathematical model describing the interaction of low-coherent speckles with bacterial cells was suggested and its parameters were determined based on experimental data. The interrelation between the life time of dynamic optical speckles and the degree of photodestruction of illuminated cells was established by computer simulations. The conditions were determined under which the photoinactivation of cells of the vaccine strain of the causative agent of F. tularensis 15 NIIEG occurs.
Asunto(s)
Simulación por Computador , Francisella tularensis/crecimiento & desarrollo , Luz , Modelos Teóricos , Francisella tularensis/efectos de la radiaciónRESUMEN
An experimental study of pyracetam (2-pyrrolidonacetamide) showed it capable to mitigate some behavioral and toxic manifestations of the action exerted by alcohol in tests on mice and rats, such as those of the "open field", "conflict situation", "rotating rod" and righting reflex. Pyracetam also attenuated some toxic symptoms of acetaldehyde in mice. It shortened the duration of coma, lessened the intensity of convulsive seizures, but it had no influence on the lethal effect of acetaldehyde. The type of the relation between doses and effects suggests the observed antagonism to be of a nonspecific nature.
Asunto(s)
Acetaldehído/envenenamiento , Intoxicación Alcohólica/tratamiento farmacológico , Piracetam/uso terapéutico , Pirrolidinonas/uso terapéutico , Acetaldehído/antagonistas & inhibidores , Intoxicación Alcohólica/complicaciones , Animales , Coma/tratamiento farmacológico , Coma/etiología , Etanol/antagonistas & inhibidores , Humanos , Ratones , Trastornos del Movimiento/tratamiento farmacológico , Trastornos del Movimiento/etiología , Ratas , Convulsiones/inducido químicamente , Convulsiones/tratamiento farmacológico , Síndrome de Abstinencia a Sustancias/tratamiento farmacológicoRESUMEN
Following introduction of triftazine (2 mg/kg) and phthoracizine 8 mg/kg, separately and in combination, the intensity of catalepsy, the content of dopamine, norepinephrine (fluorometrically), of acetylcholine (biologically) and the activity of cholinesterase (calorimetrically) in the caudate nuclei and the frontal part of the cortex were determined in rats. It was established that with its one-time administration phthoracizine, while keeping down the intensity of triftazine-induced catalepsy, prevents, at the same time, the development of a number of biochemical effects, viz. there appears a distinctly pronounced tendency toward mormalization of the dopamine, acetylcholine levels and of the cholinesterase activity. A multiple joint administration of the drugs is also attended by lowering the intensity of catalepsy. Then, biochemical changes manifest themselves in more complex interrelations.