RESUMEN
PURPOSE OF INVESTIGATION: To determine the levels of 8-hydroxydeoxyguanosine (8-OHdG) in preeclampsia (PE) using (enzyme-linked immunosorbent assay (ELISA) method. MATERIALS AND METHODS: Twenty-two pregnant women with severe PE, 18 pregnant women with mild PE, and 40 healthy pregnant women, all between 25 and 41 weeks of gestation, were enrolled in this prospective controlled study. 8-OHdG levels in maternal serum were measured using ELISA method. RESULTS: The authors observed no statistically significant difference in 8-OHdG levels between the mild-severe PE and control groups (p = 0.208). CONCLUSION: The present results do not support the concept that 8-OHdG has a role in the etiopathogenesis of PE.
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Desoxiguanosina/análogos & derivados , Preeclampsia/sangre , 8-Hidroxi-2'-Desoxicoguanosina , Adulto , Desoxiguanosina/sangre , Ensayo de Inmunoadsorción Enzimática/métodos , Femenino , Edad Gestacional , Humanos , Embarazo , Estudios Prospectivos , Índice de Severidad de la Enfermedad , Estadística como AsuntoRESUMEN
PURPOSE OF INVESTIGATION: To distinguish adnexal masses as benign and malignant, and to thereby identity the suitable surgical method for these masses, in premenopausal women, by retrospectively evaluating over a ten-year period, the diagnostic parameters, such as serum CA 125 and transvaginal ultrasonography (TVS), in combination with the presence of ascites in the abdomen. MATERIALS AND METHODS: The study was conducted with 255 premenopausal patients diagnosed with adnexal masses who had been admitted to the Gaziantep University Faculty of Medicine, Clinic of Gynecology and Obstetrics, between January 2003 and January 2013. Data collected from these patients included age, menopausal state, information regarding the presence of ascites, ultrasound findings, and serum CA 125 levels. RESULTS: The mean age of the women included in the study was 32.79 ± 8.11 (range: 18-51) years. Based on the criteria mentioned above, 152 patients were treated by laparoscopy based on a strong suspicion of benign mass, while 103 patients were treated by laparotomy, based on a strong suspicion of malignant mass. CA 125 values did not have a significant effect on malignancy risk. Based on the TVS results, three malignant masses were reported postoperatively in the patient group strongly suspected to have benign masses, while five benign masses were reported postoperatively in the patient group strongly suspected to have malignant masses.An evaluation of the present diagnostic method showed that the TVS has a positive predictive value (PPV) of 94.19% in identifying malignant masses, and a negative predictive value (NPV) of 98.22% in identifying benign masses. CONCLUSION: TVS and CA 125, along with an evaluation of menopausal status and ascites, can be an effective approach for diagnosing adnexal masses, and also for determining the proper surgical method to follow.
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Enfermedades de los Anexos/diagnóstico , Enfermedades de los Anexos/cirugía , Adolescente , Adulto , Antígeno Ca-125/sangre , Femenino , Humanos , Laparoscopía , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Premenopausia , Estudios Retrospectivos , Ultrasonografía , Adulto JovenRESUMEN
PURPOSE OF INVESTIGATION: This study aims to investigate whether hydatidiform mole (HM) disease with malignant potential is significantly associated with increased sialic acid (SA) levels. MATERIALS AND METHODS: A total of 114 women were enrolled in this study. Patients were divided into three groups including HM (Group 1, n = 34), control group including non-pregnant healthy patients (Group 2, n = 42), and another control group including healthy pregnant patients within 12 weeks of gestation (Group 3, n = 38). Serum-free SA levels were measured. RESULTS: There was a statistically significant difference in serum-free SA levels among the groups (p ≤ 0.001). Patients with HM had significantly higher levels compared to the control groups. CONCLUSION: The present study results showed that there was a significant correlation between HM and serum SA level.
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Mola Hidatiforme/sangre , Ácido N-Acetilneuramínico/sangre , Neoplasias Uterinas/sangre , Adulto , Estudios de Casos y Controles , Femenino , Humanos , Mola Hidatiforme/patología , Embarazo , Neoplasias Uterinas/patologíaRESUMEN
PURPOSE: To compare obstetric outcomes between patients with positive and negative Berlin Questionnaire results. METHODS: An observational study comparing outcome between these two groups was carried out in seven hospitals, representing seven different regions of Turkey. In each center, pregnant women who were admitted for normal pregnancy follow-up or labor, were consecutively recruited in the study. Each participant completed a sleep apnea questionnaire from the Berlin Questionnaire. This questionnaire tests snoring and daytime sleepiness. Fetal outcome and pregnancy outcome are recorded from patient files. RESULTS: A total of 465 consecutive patients who completed the Berlin Questionnaire were analyzed. Patients with a positive questionnaire had a higher BMI, pre-pregnancy medical disorder rate and cesarean rate (68% vs 51%) than the negative group. Preeclampsia and gestational diabetes were more prevalent in the positive questionnaire group than the negative questionnaire group [19 (28%) vs. 18 (5%) for preeclampsia, 8 (12) vs. 13 (3%) for gestational diabetes, respectively]. At logistic regression analysis, gravidity, gestational age at birth and a positive questionnaire were independent predictors for preeclampsia. BMI and history of maternal medical disorders were independent predictors of gestational diabetes mellitus. CONCLUSION: Obstructive sleep apnea may be related to preeclampsia.
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Complicaciones del Embarazo/epidemiología , Resultado del Embarazo/epidemiología , Trastornos del Sueño-Vigilia/epidemiología , Adulto , Comorbilidad , Femenino , Edad Gestacional , Humanos , Modelos Logísticos , Preeclampsia/epidemiología , Embarazo , Apnea Obstructiva del Sueño/epidemiología , Turquía/epidemiología , Adulto JovenRESUMEN
PURPOSE: To evaluate the serum levels of tumor markers (particularly CA 19-9) in patients with ovarian mature cystic teratomas (MCT) with respect to age, size, bilaterality, menopause, presence of adhesions, complications and the postoperative levels. METHODS: We evaluated clinical characteristics and tumor markers of 157 patients with MCT of the ovary operated at our clinic. RESULTS: CA19-9 was the only tumor marker with a mean serum level (46.95 +/- 101.11 U/ml) above the cut-off value and the elevated rate was 33.1%. Tumor size, presence of adhesions and CA 125 levels were significantly higher in patients with elevated CA 19-9. Bilaterality rate was 10.8%. The most common complication was torsion (6.4%). CONCLUSION: We suggest that elevated levels of CA 19-9 may be expected in MCTs of the ovary and that they will probably be decreased postoperatively. Therefore, postponing evaluation of other possible sources of CA 19-9 elevation in asymptomatic and young patients is more common sense.
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Biomarcadores de Tumor/sangre , Antígeno CA-19-9/sangre , Neoplasias Ováricas/sangre , Neoplasias Ováricas/patología , Teratoma/sangre , Teratoma/patología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Antígeno Ca-125/sangre , Femenino , Humanos , Menopausia , Persona de Mediana Edad , Neoplasias Ováricas/complicaciones , Neoplasias Ováricas/cirugía , Teratoma/complicaciones , Teratoma/cirugía , Adherencias Tisulares/complicaciones , Anomalía Torsional/complicaciones , Adulto JovenRESUMEN
OBJECTIVE: To discuss common pitfalls in diagnosis and management of distal vaginal agenesis, and summarize 10 years of experience among 11 patients using an interposition full-thickness graft and fibrin glue. STUDY DESIGN: Eleven patients with distal vaginal agenesis were evaluated and managed with an interposition full-thickness graft to bridge the gap between the upper vagina and the introitus. Associated renal abnormalities and complications including infection, total lack of skin graft take, stress urinary incontinence, partial graft loss, vaginal stricture and graft uptake were all investigated. RESULTS: The mean age of the patients was 12.91 (standard deviation 1.22) years. All patients had primary amenorrhoea, cryptomenorrhea, and cyclical or constant pelvic pain. None of the patients had associated urological abnormalities, and there were no cases of infection, total lack of skin graft take, stress urinary incontinence, partial graft loss or vaginal stricture. Graft uptake was 100% in 10 of the 11 patients. Four patients have subsequently married and report a satisfactory sex life. CONCLUSION: Accurate diagnosis of distal vaginal agenesis and careful pre-operative set-up, including evaluation of associated anomalies, bowel preparation, available vaginal stents and a multidisciplinary approach for the potential need for grafts, may be key to success.
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Procedimientos Quirúrgicos Ginecológicos/métodos , Vagina/anomalías , Adolescente , Amenorrea/etiología , Niño , Femenino , Adhesivo de Tejido de Fibrina/uso terapéutico , Hematocolpos/cirugía , Humanos , Trasplante de Piel/métodos , Stents , Ultrasonografía , Vagina/diagnóstico por imagen , Vagina/cirugíaRESUMEN
PURPOSE OF INVESTIGATION: The purpose of this study is to evaluate the significance of the c-Met / Hepatocyte Growth Factor Receptor (HGFR) expression in cervical intraepithelial neoplasia (CIN). MATERIALS AND METHODS: Twenty-one patients from two types of cervical intraepithelial neoplasias (LSIL and HSIL), diagnosed in our clinic were studied with c-Met immunohistochemistry. Of the 21 cases, five were diagnosed as LSIL and 16 as HSIL. Normal cervical mucosas from five patients were studied with c-Met as control cases. RESULTS: Overexpression of c-Met was found in all five of LSIL specimens. C-Met overexpression was observed in 11 cases of HSIL. No c-Met overexpression was seen in any of the five control cases. CONCLUSION: These results revealed that c-Met oncogene overexpression is an important parameter in cervical early oncogenesis and may have a role in malignant transformation of cervical epithelial cells.
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Proteínas Proto-Oncogénicas c-met/análisis , Displasia del Cuello del Útero/química , Neoplasias del Cuello Uterino/química , Transformación Celular Neoplásica , Femenino , Humanos , Inmunohistoquímica , Proteínas Proto-Oncogénicas c-met/fisiología , Neoplasias del Cuello Uterino/etiología , Displasia del Cuello del Útero/etiologíaRESUMEN
PURPOSE OF INVESTIGATION: Over the years, hysteroscopy has been increasingly performed for various gynecological disorders. In this study, we present a review of hysteroscopic procedures performed over a 7-year period. METHODS: Five hundred and eighty hysteroscopic procedures performed at the Department of Gynecology and Obstetrics, University of Gaziantep, Turkey from 2002 to 2009 were reviewed particularly highlighting the preoperative indications, postoperative diagnoses and complications associated with the procedure retrospectively. RESULTS: The most common indication for diagnostic hysteroscopy was infertility followed by AUB. The most common pathologies for referal to operative hysteroscopy were uterine septum, endometrial polyps, Asherman's syndrome, submucous myomas, and other uterine anomalies. The complication rate was 0.86% of the total hysteroscopies. False passage and uterine perforation were the most common acute complications. No late complications occurred. CONCLUSION: Our data is consistent with reports from other studies supporting that hysteroscopy is a safe and effective minimally invasive procedure with a low rate of complications with certain surgical principles.
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Histeroscopía , Enfermedades Uterinas/diagnóstico , Adolescente , Adulto , Femenino , Humanos , Histeroscopía/efectos adversos , Persona de Mediana Edad , Estudios Retrospectivos , Turquía , Adulto JovenRESUMEN
PURPOSE OF INVESTIGATION: To evaluate the effect of pregnancy on uterine myoma and the effect of uterine myoma on the pregnancy prospectively. METHODS: Prospective evaluation of 19 pregnant women with uterine myomas was done between January 2005 and February 2008 at the Gynecology and Obstetrics Department Gaziantep University. The number and changes in size of the uterine myomas during pregnancy, and perinatal complications were documented. RESULTS: Totally 37 fibroids in 19 pregnant women were observed. Neither enlargement of myomas nor serious perinatal complications were observed. CONCLUSION: We suggest that in contrast with the general opinion there is not much effect of pregnancy on uterine myoma size, and most cases are not affected by the presence of uterine fibroids resulting in severe perinatal complications. Expectant management may be an option for uterine myomas determined before gestation.
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Cesárea , Leiomioma/complicaciones , Complicaciones Neoplásicas del Embarazo , Neoplasias Uterinas/complicaciones , Adulto , Femenino , Humanos , Leiomioma/patología , Embarazo , Estudios Prospectivos , Neoplasias Uterinas/patologíaRESUMEN
OBJECTIVE: We aimed to evaluate the knowledge and interest level of Turkish women about HPV, HPV vaccines and cervical cancer using a questionaire. METHOD: A 25-item questionnaire was distributed to women in three different cities located in separate sociocultural locations. RESULTS: At the closure of the study 143 women responded and returned the survey. Of the participants 62.2% (89) had a university degree, 36.4% (52) a high school education, and 1.4% (2) had lower school degrees; 98.5% of the women would consent to have their daughter vaccinated for HPV and 94.7% would consent to have their son vaccinated if vaccine provided prevention against cancer and related diseases. However in both cases women gave importance to the "cost" - unless vaccine could be free. On logistic regression analyses none of the variables (i.e., questions) in the survey predicted women's willingness to accept the vaccine for themselves or their children. CONCLUSIONS: Women in Turkey would be willing to have themselves and their children receive HPV vaccine against cervical cancer and related diseases.
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Conocimientos, Actitudes y Práctica en Salud , Infecciones por Papillomavirus/inmunología , Vacunas contra Papillomavirus/uso terapéutico , Neoplasias del Cuello Uterino/virología , Adolescente , Adulto , Alphapapillomavirus/patogenicidad , Recolección de Datos , Femenino , Humanos , Pacientes Ambulatorios , Infecciones por Papillomavirus/transmisión , Vacunas contra Papillomavirus/economía , Turquía , Neoplasias del Cuello Uterino/prevención & controlRESUMEN
OBJECTIVE: There are many methods of treatment of vaginal agenesis. METHODS: In this study, patients who underwent McIndoe vaginoplasty were evaluated for development of vaginal mucosa. Vaginal pH measurements, smears, and punch biopsies were obtained from seven patients postoperatively at 3, 6, and 12 months after having McIndoe vaginoplasty. RESULTS: Neovaginal smears indicated no specific data for mucosal development at the 3rd and 6th month after the operation. However, Doderlein bacilli were determined at the 12th month. Histopathological examination of punch biopsies revealed dermal and subdermal thickening at the 3rd month, partial adaptation to mucosa at 6th month, and full adaptation to mucosa at 12th month. Also normal vaginal pH levels were recorded at the 12th month. CONCLUSION: As a result of the adaptation process, the split thickness skin graft acquired both histological and physiological characteristics of normal vaginal mucosa. Also, neovaginal epithelium was evaluated to be macroscopically similar to normal vaginal mucosa, 12 months after the operation.
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Adaptación Fisiológica/fisiología , Membrana Mucosa/fisiopatología , Regeneración/fisiología , Trasplante de Piel , Vagina/anomalías , Vagina/fisiopatología , Adolescente , Adulto , Femenino , Estudios de Seguimiento , Humanos , Factores de Tiempo , Resultado del Tratamiento , Vagina/cirugíaRESUMEN
OBJECTIVE: This study aimed to investigate and speculate on the dietary habits and certain environmental factors of the Southeast Anatolia region which are thought to be related with fetal anomaly development. MATERIALS AND METHODS: Patients admitted to Gaziantep University Faculty of Medicine Obstetrics and Gynecology Department with fetal anomalies between January 2003 and June 2007 were evaluated. Three hundred and fifteen patients with intrauterine fetal anomaly were detected. The number of total deliveries during this period were 7,554. Twenty-eight of the patients were above the age of 35. According to the history of patient, mean gravidity was 6.6 (1-13), consanguineous marriage rate was 25%, previous abnormal rate was 15%, and previous missed abortion was 35%. Eighty-eight percent of patients were of low sociocultural status. The frequency of daily dietary habits, especially tea consumption, red chili pepper consumption and eating barbecued meat were questioned with the anamnesis. RESULTS: Total fetal anomaly incidence was found to be 4.17%, neural tube defects 1.37%, renal anomalies 0.54%, non-immune fetal hydrops 0.46%, cystic hygroma 0.39%, central nervous system anomalies 0.36%, chromosomal anomalies 0.17%, gastrointestinal system anomalies 0.147%, sacrococcygeal teratoma 0.12%, cardiac anomalies 0.09%, and respiratory system anomalies 0.049%. Mean daily tea comsumption during pregnancy was 8 cups/day. Mean frequency of eating barbecued meat was 4 times/week. Mean chili pepper consumption was 10 g/day. CONCLUSION: In this study, four times higher overall fetal anomaly incidence appeared to be strongly correlated with Southeast Anatolia region's dietary habits. In the future monitoring women's dietary habits should have an important role in the prevention of fetal anomaly development.
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Anomalías Congénitas/etiología , Conducta Alimentaria , Embarazo , Adolescente , Adulto , Estudios de Cohortes , Anomalías Congénitas/epidemiología , Femenino , Humanos , Incidencia , Persona de Mediana Edad , Efectos Tardíos de la Exposición Prenatal , Estudios Retrospectivos , Factores de Riesgo , Turquía/epidemiología , Adulto JovenRESUMEN
AIM: To determine whether serum CA-125 levels, in addition to tumor size and ultrasonographic findings can help in differentiating benign ovarian cysts from malignant disease. METHODS: All postmenopausal women who had undergone explorative laporatomy for a preoperative diagnosis of an adnexal cyst between January 1999 and February 2006 were included if serum CA-125 levels were below 50 IU/ml. RESULTS: Ninety-three patients with ovarian cysts and serum CA-125 levels lower than 50 IU/ml were included. Seventy-five (80%) of the patients (53 unilocular, 22 multilocular) had ovarian cysts < 13 cm. Of 18 patients with ovarian cysts > 13 cm, seven had unilocular and 11 had multilocular cysts. All the patients (n = 77) with a serum CA-125 level < 35 IU/ml had benign histopathology regardless of the tumor size or ultrasonic features. Among 16 patients with CA-125 levels between 35 and 50 IU/ml, two with unilocular cysts > 13 cm and nine with multilocular cysts (3 < 13 cm, 6 > 13 cm) had borderline histopathology. CONCLUSION: We concluded that when unilocular ovarian cyst size is < 13 cm and serum CA-125 levels are below 35 IU/ml in a postmenopausal woman, the possibility of a benign etiology is most likely.
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Antígeno Ca-125/sangre , Quistes Ováricos/diagnóstico , Quistes Ováricos/metabolismo , Posmenopausia , Adulto , Femenino , Humanos , Persona de Mediana Edad , Quistes Ováricos/patología , Estudios Retrospectivos , Salud de la MujerRESUMEN
OBJECTIVE: The aim of our study was to detect any rise in serum levels of CA-125 after hysterosalpingography (HSG) as a result of irritation of the peritoneum. STUDY DESIGN: Serum levels of CA-125 were assessed before HSG and at the 2nd and 6th hours after HSG in 32 infertile patients who were admitted to our clinic from April 2002 to September 2002. Patients who showed tubal occlusion or Asherman Syndrome were excluded from the study. The levels of serum CA-125 were compared statistically. Statistical analysis was performed with SPSS 10.0 statistical software and the paired-sample t-test was applied. RESULTS: The mean levels of serum CA-125 before HSG, and at the 2nd and 6th hours after HSG were; 14.11 +/- 5.97 mIU/ml, 13.96 +/- 5.80 mIU/ml, and 14.06 +/- 5.80 mIU/ml, respectively. There was no statistically significant difference between serum levels of CA-125 before HSG and at the 2nd or 6th hours after HSG, and also between the 2nd and 6th hours after HSG (p > 0.05). CONCLUSION: We have not found any reports up to date about the levels of serum CA-125 after HSG. In our study we did not detect any increase in levels of serum CA-125 at the 2nd and 6th hours after HSG in spite of peritoneal irritation. We propose that this finding is because leakage of radioopaque material to the abdominal cavity is minimal during the HSG procedure.
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Antígeno Ca-125/sangre , Histerosalpingografía/efectos adversos , Peritonitis/sangre , Adulto , Biomarcadores/sangre , Femenino , Humanos , Peritonitis/etiologíaRESUMEN
Surgical stress may cause neural, endocrine, metabolic and humoral responses depending on the severity of the procedure. In this study, we aimed to study the effect of the preoperatively given ascorbic acid (AA), which is an antioxidant, and its role in the biosynthesis of neuropituitary hormones on the surgical stress response. Twenty-two American Society of Anaesthesiologists I and II patients ageing between 18 and 40, who have no endocrine and metabolic disease, and undergoing abdominal operation for non-malignant diseases were allocated to the study. These non-premedicated patients were divided into two groups in random: Group I, etomidate group; and Group II, AA plus etomidate group. AA was given to patients in Group II 20min before etomidate injection. After monitoring the patient, anaesthetic induction was applied by giving 0.3 mg/kg of etomidate, 2 microg/kg of fentanyl and 0.1 mg/kg of vecuronium. Anaesthesia was continued with 1-0.7% isoflurane and N2O/O2 (67 and 37%, respectively). Tramadol was given for the management of post-operative analgesia. Blood samples were obtained from all patients before the operation and at second, sixth, twelfth and twenty-forth hours after the beginning of operation for cortisol, adrenocorticotropic hormone (ACTH), osteocalcin, insulin and blood glucose level analyses. There was no statistically significant difference in cortisol, osteocalcin, insulin and glucose levels in both groups, when compared to the control levels. Whereas, patients in Group II had higher levels of cortisol than the control group at sixth hour, which were in normal limits, and there was no decrease in osteocalcin concentration. ACTH level was increased at the second and sixth hours, which was statistically significant, but at twelfth and twenty-forth hours, they were close to control group levels. As a result, we conclude that AA given before anaesthesia achieved by etomidate is not sufficient for the prevention of surgical stress response and that AA induction before anaesthesia should be preferred, particularly for the prevention of decrease in osteocalcin levels.
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Anestésicos Intravenosos/administración & dosificación , Antioxidantes/administración & dosificación , Ácido Ascórbico/administración & dosificación , Etomidato/administración & dosificación , Histerectomía/psicología , Estrés Fisiológico/prevención & control , Adolescente , Hormona Adrenocorticotrópica/sangre , Adulto , Glucemia/análisis , Quimioterapia Combinada , Femenino , Humanos , Hidrocortisona/sangre , Insulina/sangre , Osteocalcina/sangre , Estrés Fisiológico/sangre , Resultado del TratamientoRESUMEN
There is no adequate data in the medical literature defining serum CA-125 levels after laparotomy. Therefore we designed this prospective study to evaluate the effects of laparotomy for hysterectomy on serum CA-125 levels. Ninety-four women (mean age 44.6 +/- 6.9 years) were included in the study between January, 2001 and April, 2003. Hysterectomies were performed in patients with chronic pelvic pain, dysfunctional uterine bleeding and myoma uteri. Mean serum CA-125 levels of the patients before and after laparotomy were 16.29 +/- 8.11 U/ml and 16.37 +/- 8.05 U/ml, respectively. The change in serum CA-125 levels prior to the operation was statistically insignificant when compared with the levels obtained at 24 hours after laparotomy (p > 0.05). We found that laparotomy for hysterectomy did not change the levels of CA-125 at the 24th hour after the operation, indicating either serum CA-125 levels are not correlated, at least within 24 hours, with peritoneal irritation or peritoneal irritation was minimal or absent in our operations.
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Antígeno Ca-125/sangre , Histerectomía , Laparoscopía , Adulto , Femenino , Humanos , Periodo PosoperatorioRESUMEN
There is no adequate data in the medical literature defining serum CA-125 levels after laparoscopy. Therefore we designed this prospective study to evaluate the effects of laparoscopy on serum CA-125 levels. Eighty-two women (mean age 34.2 +/- 12.30 years) were included in the study between January, 2001 and April, 2003. Laparoscopies were performed in patients with chronic pelvic pain, dysmenorrhea, infertility, ovarian cysts and for tubal ligation. Mean serum CA-125 levels of the patients before and after the laparoscopic procedures were 13.96 +/- 4.86 U/ml and 14.02 +/- 4.96 U/ml, respectively. The change in serum CA-125 levels prior to laparoscopy was statistically insignificant when compared with the levels obtained at 24 hours after laparoscopic procedure (p > 0.05). We found that diagnostic laparoscopy or laparoscopic surgical procedures did not change the levels of CA-125 at the 24th hour after laparoscopy indicating either serum CA-125 levels are not correlated, at least within 24 hours, with peritoneal irritation or peritoneal irritation is minimal or absent in our operations.
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Antígeno Ca-125/sangre , Laparoscopía , Adulto , Estudios de Casos y Controles , Femenino , Humanos , Infertilidad Femenina/cirugía , Quistes Ováricos/cirugía , Dolor Pélvico/cirugía , Estudios Prospectivos , Esterilización TubariaRESUMEN
A combination of a paclitaxel and platinum analog is currently the standard first-line chemotherapy for women with ovarian cancer, with response rates of 20-37%. As patients who relapse have a poor prognosis and treatment options are limited, there is an urgent need to develop new agents with novel mechanisms of action for use as a second-line, non-cross-resistant chemotherapy in ovarian cancer. In this report, we describe a patient with platinum/paclitaxel-refractory ovarian cancer who received topotecan and reached long-term stabilization of her disease. The patient was administered 1.5 mg/m2 topotecan for five days in 17 cycles. She was also given granulocyte colony-stimulating factor (G-CSF) support to prevent severe granulocytopenia; no hematologic toxic effect was experienced. Her quality of life was good throughout the treatment, and also her daily activities were unaffected.
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Adenocarcinoma Papilar/tratamiento farmacológico , Neoplasias Ováricas/tratamiento farmacológico , Topotecan/uso terapéutico , Adenocarcinoma Papilar/cirugía , Agranulocitosis/inducido químicamente , Agranulocitosis/tratamiento farmacológico , Resistencia a Antineoplásicos , Resultado Fatal , Femenino , Factor Estimulante de Colonias de Granulocitos/administración & dosificación , Humanos , Persona de Mediana Edad , Neoplasias Ováricas/cirugía , Paclitaxel/uso terapéutico , Compuestos de Platino/uso terapéutico , Calidad de Vida , Topotecan/efectos adversosRESUMEN
Trace elements are extremely important in human metabolism, growth, and tissue repair. The risk of nutritional disturbances, in particular, vitamin and trace element deficiencies, are striking during menopause. The aim of this longitudinal study was to evaluate the effect of estrogen treatment on serum levels of copper, zinc, magnesium, calcium, vitamin E, and vitamin A in menopausal women. Thirty-eight menopausal women were included in the study, and were administered a continuous hormone replacement therapy (HRT) of 0.625 mg conjugated equine estrogen (CEE) and 2.5 mg medroxyprogesterone acetate (MPA). Blood samples were obtained before and six months after HRT. There was a statistically significant difference between levels of serum copper, zinc, magnesium, calcium, vitamin E and vitamin A before and after HRT (p < 0.001). In conclusion we observed a beneficial effect of HRT on serum levels of trace elements, vitamin A, and vitamin E in addition to the well known other benefits.
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Terapia de Reemplazo de Estrógeno , Posmenopausia/sangre , Oligoelementos/sangre , Vitamina A/sangre , Vitamina E/sangre , Calcio/sangre , Cobre/sangre , Estrógenos Conjugados (USP)/administración & dosificación , Femenino , Humanos , Estudios Longitudinales , Magnesio/sangre , Acetato de Medroxiprogesterona/administración & dosificación , Congéneres de la Progesterona/administración & dosificación , Zinc/sangreRESUMEN
The aim of this study was to determine the effects of tobacco use and consumption of caffeine in pregnancy on the fetus and placenta by measuring the body weights, head circumferences, and lengths of newborns, and also weights and diameters of placentas. In this prospective study, two main groups were chosen for the study: Group I: A total of 63 pregnant non-smokers; were separated into two subgroups according to their daily caffeine intake; less than 300 mg (Ia) (n = 44), and more than 300 mg (Ib) (n = 19). Group II: 60 pregnant smokers were also separated into two subgroups; daily caffeine intake less than 300 mg (IIa) (n = 43), and more than 300 mg (IIb) (n = 17). The newborns and placentas of both groups were examined. The body weights, lengths, and head circumferences of newborns and also weights and diameters of placentas were measured. The pregnant non-smokers consuming caffeine more than 300 mg/day had statistically significant lower weights of newborns and placentas (p < 0.05). However, there was no significant difference between groups according to the lengths, head circumferences of newborns and diameters of placentas. There were significantly lower body weights of newborns and placentas in pregnant smokers (p < 0.05). There was no difference according to the diameters of placentas, and lengths and head circumferences of newborns in either group. In conclusion, it is suggested that smoking in pregnancy should be prevented both for the health of newborns and mothers, and also caffeine including beverages like tea and coffee should be limited in pregnancy.