RESUMEN
INTRODUCTION: The direct laryngoscopy technique using a Macintosh blade is the first choice globally for most anaesthetists. In case of an unanticipated difficult airway, the complication rate increases with the number of intubation attempts. Recently, McGrath MAC (McGrath) video laryngoscopy has become a widely accepted method for securing an airway by tracheal intubation because it allows the visualisation of the glottis without a direct line of sight. Several studies and case reports have highlighted the benefit of the video laryngoscope in the visualisation of the glottis and found it to be superior in difficult intubation situations. The aim of this study was to compare the first-pass intubation success rate using the (McGrath) video laryngoscope compared with conventional direct laryngoscopy in surgical patients. METHODS AND ANALYSIS: The EMMA trial is a multicentre, open-label, patient-blinded, randomised controlled trial. Consecutive patients requiring tracheal intubation are randomly allocated to either the McGrath video laryngoscope or direct laryngoscopy using the Macintosh laryngoscope. The expected rate of successful first-pass intubation is 95% in the McGrath group and 90% in the Macintosh group. Each group must include a total of 1000 patients to achieve 96% power for detecting a difference at the 5% significance level. Successful intubation with the first attempt is the primary endpoint. The secondary endpoints are the time to intubation, attempts for successful intubation, the necessity of alternatives, visualisation of the glottis using the Cormack & Lehane score and percentage of glottic opening score and definite complications. ETHICS AND DISSEMINATION: The project was approved by the local ethics committee of the Medical Association of the Rhineland Palatine state and Westphalia-Lippe. The results of this study will be made available in the form of manuscripts for publication and presentations at national and international meetings. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT 02611986; pre-results.
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Glotis , Intubación Intratraqueal/instrumentación , Laringoscopios/estadística & datos numéricos , Cirugía Asistida por Video/instrumentación , Anestesia General , Femenino , Alemania , Humanos , Laringoscopía/instrumentación , Masculino , Estudios Prospectivos , Análisis de Regresión , Proyectos de InvestigaciónRESUMEN
BACKGROUND: Neurosurgical procedures in sitting position need advanced cardiovascular monitoring. Transesophageal echocardiography (TEE) to measure cardiac output (CO)/cardiac index (CI) and stroke volume (SV), and invasive arterial blood pressure measurements for systolic (ABPsys), diastolic (ABPdiast) and mean arterial pressure (MAP) are established monitoring technologies for these kind of procedures. A noninvasive device for continuous monitoring of blood pressure and CO based on a modified Penaz technique (volume-clamp method) was introduced recently. In the present study the noninvasive blood pressure measurements were compared with invasive arterial blood pressure monitoring, and the noninvasive CO monitoring to TEE measurements. METHODS: Measurements of blood pressure and CO were performed in 35 patients before/after giving a fluid bolus and a change from supine to sitting position, start of surgery, and repositioning from sitting to supine at the end of surgery. Data pairs from the noninvasive device (Nexfin HD) versus arterial line measurements (ABPsys, ABPdiast, MAP) and versus TEE (CO, CI, SV) were compared using Bland-Altman analysis and percentage error. RESULTS: All parameters compared (CO, CI, SV, ABPsys, ABPdiast, MAP) showed a large bias and wide limits of agreement. Percentage error was above 30% for all parameters except ABPsys. CONCLUSION: The noninvasive device based on a modified Penaz technique cannot replace arterial blood pressure monitoring or TEE in anesthetized patients undergoing neurosurgery in sitting position.
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Hemodinámica , Procedimientos Neuroquirúrgicos/métodos , Posicionamiento del Paciente , Adulto , Anciano , Anestesia General , Presión Arterial , Presión Sanguínea , Determinación de la Presión Sanguínea , Gasto Cardíaco , Ecocardiografía Transesofágica , Femenino , Humanos , Masculino , Persona de Mediana Edad , Monitoreo Intraoperatorio , Postura/fisiología , Reproducibilidad de los Resultados , Volumen Sistólico , Posición SupinaRESUMEN
PURPOSE: Since certain surgical procedures still require a sitting or reverse Trendelenburg position, it remains important to evaluate the risk for paradoxical embolization. Intracardiac shunting, the most common cause being a patent foramen ovale, can be excluded by contrast-enhanced transesophageal echocardiography. There are, however, less described cases which result from patency of intrapulmonary functional arteriovenous anastomoses and lead to extra-cardiac paradoxical air embolism during anesthesia. We report a unique case to increase awareness of this real and potentially dangerous complication. CLINICAL FEATURES: A 52-yr-old male was scheduled for resection of a tumour at the cerebellopontine angle. Preoperative evaluation excluded intracardiac shunts. During a craniotomy in the sitting position, recurrent venous air emboli entered the patient's right heart, leading to a sudden decline in end-tidal CO(2), an increase in PaCO(2), and a reduction of PaO(2). The exact source of surgical entrance could not be identified; therefore, the surgical wound was closed provisionally and the patient was repositioned supine to prevent further venous air emboli. During transition to the supine position, we observed clinically significant crossover of air into the left heart originating from the left pulmonary vein, as detected by transesophageal echocardiography. In all likelihood, the etiology was an opening of intrapulmonary right-to-left anastomoses. The patient recovered without neurological or pulmonary sequelae. CONCLUSION: In the presence of massive venous air emboli, intrapulmonary right-to-left paradoxical air emboli can occur while intraoperatively transitioning a patient from the sitting to the supine position.
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Craneotomía/métodos , Embolia Aérea/etiología , Postura , Anestesia/métodos , Anastomosis Arteriovenosa/patología , Análisis de los Gases de la Sangre , Dióxido de Carbono/sangre , Ecocardiografía Transesofágica/métodos , Humanos , Masculino , Persona de Mediana Edad , Oxígeno/sangre , Venas Pulmonares , Posición SupinaRESUMEN
Mediastinal mass syndrome remains an anaesthetic challenge that cannot be underestimated. Depending on the localization and the size of the mediastinal tumour, the clinical presentation is variable ranging from a complete lack of symptoms to severe cardiorespiratory problems. The administration of general anaesthesia can be associated with acute intraoperative or postoperative cardiorespiratory decompensation that may result in death due to tumour-related compression syndromes. The role of the anaesthesiologist, as a part of the interdisciplinary treatment team, is to ensure a safe perioperative period. However, there is still no structured protocol available for perioperative anaesthesiological procedure. The aim of this article is to summarize the genesis of and the diagnostic options for mediastinal mass syndrome and to provide a solid detailed methodology for its safe perioperative management based on a review of the latest literature and our own clinical experiences. Proper anaesthetic management of patients with mediastinal mass syndrome begins with an assessment of the preoperative status, directed foremost at establishing the localization of the tumour and on the basis of the clinical and radiological findings, discerning whether any vital mediastinal structures are affected. We have found it helpful to assign 'severity grade' (using a three-grade clinical classification scale: 'safe', 'uncertain', 'unsafe'), whereby each stage triggers appropriate action in terms of staffing and apparatus, such as the provision of alternatives for airway management, cardiopulmonary bypass and additional specialists. During the preoperative period, we are guided by a 12-point plan that also takes into account the special features of transportation into the operating theatre and patient monitoring. Tumour compression on the airways or the great vessels may create a critical respiratory and/or haemodynamic situation, and therefore the standard of intraoperative management includes induction of anaesthesia in the operating theatre on an adjustable surgical table, the use of short-acting anaesthetics, avoidance of muscle relaxants and maintenance of spontaneous respiration. In the case of severe clinical symptoms and large mediastinal tumours, we consider it absolutely essential to cannulate the femoral vessels preoperatively under local anaesthesia and to provide for the availability of cardiopulmonary bypass in the operating theatre, should extracorporeal circulation become necessary. The benefits of establishing vascular access under local anaesthesia clearly outweigh any associated degree of patient discomfort. In the case of patients classified as 'safe' or 'uncertain', a preoperative consensus with the surgeons should be reached as to the anaesthetic approach and the management of possible complications.
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Anestesia , Neoplasias del Mediastino/cirugía , Atención Perioperativa , Adulto , Humanos , Complicaciones Intraoperatorias/terapia , Cuidados PosoperatoriosRESUMEN
Positive pressure ventilation in children is associated with problems similar to those in the adults: development of atelectasis and barotrauma. During anesthesia atelectasis develop in up to 90% of patients, requiring the use of higher inspiratory pressure to recruit the collapsed lung regions. Especially in the preterm, newborn and younger infants, prolonged ventilation disturbs the anatomical structure of the soft and vulnerable immature airways and their subsequent growth and development, leading to tracheomegaly, tracheal collapse, and bronchopulmonary dysplasia and predisposing to bronchial obstruction. On the basis of pathophysiologic knowledge and studies of ventilation in children, protective modes of ventilation have evolved. They allow to reopen atelectatic lung regions without overdistension. Through solid knowledge of the underlying pediatric physiology and pathophysiology, the required ventilation management can be optimally adjusted to the young patients in order to achieve the best long-term outcomes.
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Anestesia/métodos , Anestésicos/administración & dosificación , Enfermedades Pulmonares/fisiopatología , Enfermedades Pulmonares/terapia , Pulmón/efectos de los fármacos , Pulmón/fisiopatología , Respiración con Presión Positiva/métodos , Niño , HumanosRESUMEN
We describe the anesthetic concept and approach in a single lung patient scheduled for pulmonary artery stenting due to recurrence of a pulmonary artery sarcoma after left pneumectomy.
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Circulación Extracorporea , Paro Cardíaco Inducido , Arteria Pulmonar , Sarcoma/cirugía , Stents , Neoplasias Vasculares/cirugía , Humanos , Masculino , Persona de Mediana EdadRESUMEN
We present a patient with hepatitis C and D and hepatocellular carcinoma who underwent preoperative evaluation for orthotopic liver transplantation. In his past medical history, he reported a life-threatening event during tonsillectomy in 1975. Intubation was impossible due to extreme jaw muscle tension, followed by excessive elevation in body temperature, tachycardia, and coma for a few days. We evaluated him for malignant hyperthermia, according to the European Malignant Hyperthermia Group Protocol, and found him highly positive in both the halothane and caffeine test, respectively. Three months later, we performed an orthotopic liver transplantation. During retransplantation 4 years later, due to ischemic-type biliary lesions, he suffered massive intraoperative bleeding. Blood products, as well as coagulation factors and aprotinin, were well tolerated. Anesthesia was performed in a trigger-free total intravenous technique without dantrolene prophylaxis, but dantrolene was readily available in sufficient quantities in the operating room. The patient did not encounter a malignant hyperthermia crisis in either perioperative period.