RESUMEN
The data on the capacity of 50 melanogenic and 50 amelanogenic P. aeruginosa strains to produce hemolysins, gelatinase, caseinase, DNAase, RNAase, lecithinase, elastase, neuraminidase and to form extracellular slime, obtained in the comparative study of these strains in vitro, are presented. Melanogenic P. aeruginosa cultures were found to have a higher lecithinase and neuraminidase activity. The strains incapable of melanogenesis formed slime more frequently. The properties of the strains in respect to other pathogenicity characteristics under study were identical.
Asunto(s)
Melaninas/biosíntesis , Pseudomonas aeruginosa/patogenicidad , Hialuronoglucosaminidasa/metabolismo , Neuraminidasa/metabolismo , Elastasa Pancreática/metabolismo , Fosfolipasas/metabolismo , Pseudomonas aeruginosa/metabolismoRESUMEN
Gentamicin is one of the most effective drugs for treatment of infections caused by Ps. aeruginosa. However, isolation of the strains resistant to the antibiotics was not infrequent. It was shown in the experiments with 40 cultures that the activity of gentamicin against Ps. aeruginosa increased approximately 20 times when it was used in combination with ethonium, a derivative of bis-quaternary ammonium compounds.
Asunto(s)
Gentamicinas/farmacología , Pseudomonas aeruginosa/efectos de los fármacos , Compuestos de Amonio Cuaternario/farmacología , Relación Dosis-Respuesta a Droga , Combinación de Medicamentos , Sinergismo FarmacológicoRESUMEN
Sensitivity of microflora to tetracycline, oxytetracycline, chlortetracycline and doxycicline was studied. A total of 237 pure cultures of Strep. viridans (54), beta-hemolytic streptococci (27), pathogenic staphylococci (52), non-pathogenic staphylococci (53) and Coli bacteria (51) were tested with the agar-diffusion method using standard discs. Doxycicline was most active and chortetracycline was least active. The maximum sensitivity to doxycicline was found in beta-hemolytic streptococci (85.4%) and the minimum sensitivity to that antibiotic was found in Coli bacteria (39.2%) and Strep. viridans (35.6%), which was superior to that with respect to the other tetracyclines. Coincidence of the clinical effect with the microflora sensitivity and high percentage of sensitivity to doxycicline among Staph. aureus, which is important in treatment of severe infections caused by the organism were observed.