RESUMEN
In December 1973 a technician was accidentally irradiated when attempting to bring under control a sealed 60Co source (110 TBq) which had been lodged in the head of a medical irradiation unit during a replacement operation. In the early period after the accident, severe skin changes on the left hand, epilation in a small area of the left temporal region and minor deviations in peripheral blood developed. In the following years, repeated surgery due to secondary skin defects of the left hand resulted in the loss of the fingers 2-5. Since 1975, changes in the lens of the left eye began to appear leading gradually to the deterioration of visual acuity. Later, opacities of the lens of the right eye were found. The patient's psychological and emotional attitude about the accident changed in the course of time. The factors influencing the psychic state of the patient are identified.
Asunto(s)
Accidentes de Trabajo , Traumatismos por Radiación/etiología , Adulto , Catarata/etiología , Radioisótopos de Cobalto , Checoslovaquia , Ojo/patología , Ojo/efectos de la radiación , Estudios de Seguimiento , Rayos gamma , Traumatismos de la Mano/etiología , Traumatismos de la Mano/patología , Humanos , Masculino , Traumatismos por Radiación/patología , Traumatismos por Radiación/psicología , Tecnología RadiológicaRESUMEN
The problem of data input into the computer was solved by means of an electromechanical scanner of our own design, which processes information from a positive photocopy. Classification of chromosomes in homologous pairs uses linear functions of discriminant variables. Evaluation of the quality of discriminant variables is based on multivariate generalization of analysis of variance and on Wilks' statistics. The success of the system described depends generally on the reproducibility of banding, on the loss of information during photographic process, on the parameters of the equipment used, as well as on the mathematical methods employed. The results were obtained from an analysis of 27 male and female diploid sets from the normal population and they are fully comparable with other systems, although no direct processing of the sets from the preparation is used.
Asunto(s)
Cromosomas Humanos/análisis , Computadores , Aberraciones Cromosómicas , Bandeo Cromosómico , Femenino , Humanos , Masculino , MinicomputadoresAsunto(s)
Neoplasias Inducidas por Radiación/epidemiología , Enfermedades Profesionales/epidemiología , Radio (Elemento)/efectos adversos , Radioisótopos de Estroncio/efectos adversos , Adulto , Anciano , Aberraciones Cromosómicas , Checoslovaquia , Exposición a Riesgos Ambientales , Humanos , Masculino , Persona de Mediana Edad , Factores de TiempoRESUMEN
The mutagenic activity of fenitrothion was studied in rats given 0,10,40 or 80 ppm of fenitrothion in the diet. The study combined the dominant lethal test with cytogenetic analysis of chromosomal aberrations. Dominant lethal mutations were investigated: 1. by their so-called tentative determination in single mating in P-to F3 generation males and females following 200 days exposure; 2. by assessing the effect of the agent at individual stages of spermatogenesis, with F2 and F4 generation males having been exposed for 100 days and mated to unexposed females for 10 weeks. Chromosome aberrations were analyzed in the bone marrow of F2 generation males following 200-days exposure and F3 generation (males) following 500-day exposure to a dose of 80 ppm. Negative results were obtained in all experiments in relation both to dose and generation. Hence fenitrothion is not considered to be a substance with a mutagenic activity. The metodical advantages of the proposed combination of reproduction and mutagenic-activity studies of an agent for toxicological evaluation are discussed.