RESUMEN
Continuous subcutaneous administration of 16 mg/kg body weight 1,2-dimethylhydrazine three times a month (total dose--1080-3696 mg) to Macaca fascicularis monkeys induced cancer invariably confined to the colon within 34-47 weeks. Biologic, clinical, histologic features and natural course of the tumor proved similar to those of its human counterpart.
Asunto(s)
Adenocarcinoma/inducido químicamente , Carcinógenos/toxicidad , Dimetilhidrazinas/toxicidad , Neoplasias Intestinales/inducido químicamente , Intestino Grueso , Metilhidrazinas/toxicidad , 1,2-Dimetilhidrazina , Adenocarcinoma/patología , Animales , Relación Dosis-Respuesta a Droga , Femenino , Inyecciones Subcutáneas , Neoplasias Intestinales/patología , Intestino Grueso/patología , Metástasis Linfática , Macaca fascicularis , Masculino , Factores de TiempoRESUMEN
Gastric tumors were detected in 2 out of 9 apes following MNNG treatment with a total dose of 800-848 mg/kg (40 mg/kg, thrice a month, 49-50 weeks, via gastric probe). The characteristics, course, symptoms and histologic patterns of the tumors proved comparable with similar neoplasms in humans.
Asunto(s)
Enfermedades de los Monos/inducido químicamente , Nitrosoguanidinas/toxicidad , Neoplasias Gástricas/inducido químicamente , Animales , Relación Dosis-Respuesta a Droga , Femenino , Macaca fascicularis , Masculino , Enfermedades de los Monos/patología , Estómago/efectos de los fármacos , Estómago/patología , Neoplasias Gástricas/patología , Factores de TiempoRESUMEN
The antitumour activity of 10 analogs of nitroso alkyl urea was studied on 6 tumour strains. It was shown that antitumour effect depends upon the gentle structural changes of substances (changes of side chain, the position of aromatic nucleus in it, as well as the nature, quantity and position of substitutes in the nucleus). 7 compounds out of 10 analogs of nitroso alkyl urea have manifested antitumour activity.
Asunto(s)
Antineoplásicos/uso terapéutico , Compuestos de Nitrosourea/uso terapéutico , Animales , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Ratones , Trasplante de Neoplasias , Neoplasias Experimentales/tratamiento farmacológico , Ratas , Inducción de Remisión , Relación Estructura-Actividad , Factores de TiempoRESUMEN
According to the data obtained by the authors, some modifying factors, and in particular artificial disorders of hormonal balance in rats, influence the realization of the blastomogenic effect of methylnitrosourea. The results of these studies indicate that the manifestation and the development of tumors in the peripheral nerves occurs more rapidly and easier in experimental hypothyrosis due to a daily administration of anti-thyroid drugs (merkazolyl) and an estrogenation of the organism of animals by a monthly subcutaneous suturation of sinestrol pills. In castration and administration of thyroid hormones (thyroidin) the amount of experimental neurogenic newgrowths decreases with an extension of the latent period of their development.