RESUMEN
Dry aspen (Populus tremula L.) bark extract exhibits antiulcerogenic activity as demonstrated by the results of experiments using the models of gastric ulcers in rats according to H. Shay. The cytoprotective action of the dry aspen bark extract was also demonstrated in experiments on dogs with fistula according to Basov.
Asunto(s)
Antiulcerosos/farmacología , Mucosa Gástrica/efectos de los fármacos , Estómago/efectos de los fármacos , Árboles/química , Animales , Perros , Femenino , Jugo Gástrico/metabolismo , Mucosa Gástrica/metabolismo , Ligadura , Úlcera Péptica/tratamiento farmacológico , Úlcera Péptica/fisiopatología , Extractos Vegetales/farmacología , Píloro , Ratas , Ratas WistarRESUMEN
A new drug preparation ecorsin based on the dry aspen bark extract was studied for toxicological safety on a preclinical stage. The drug exhibited no toxicity upon a single administration to rats and mice (both male and female). The intragastric administration of ecorsin for 3 months to rats (at a daily dose of 50, 250, and 500 mg/kg) and rabbits (25 and 50 mg/kg) led to neither functional not morphological changes in hemopoietic and lymphoid organs, liver, kidney, heart, digestive system, and CNS. The long-term administration resulted in a partial atrophic modification of convoluted seminiferous tubules in impuberal male rats, while not affecting the testes of aged animals. The administration of ecorsin at 50, 250, and 500 mg/kg led to dose-dependent changes in some characteristics of the reproductive capacity in rats. Ecorsin did not modify the extent of allergic reactions and produced no immunotoxicant and mutagen effects.
Asunto(s)
Antiulcerosos/toxicidad , Extractos Vegetales/toxicidad , Árboles/química , Animales , Femenino , Masculino , Ratones , Ratones Endogámicos CBA , Pruebas de Mutagenicidad , Conejos , Ratas , Ratas Wistar , Pruebas de ToxicidadRESUMEN
Dry aspen bark extract exhibits pronounced antiulcerogenic activity as demonstrated by the results of experiments using the models of histamine and atophan induced ulcers and the ulceration model according to H. Shay. The gastroprotector activity is manifested by decreasing number of animals with ulceration damage in the mucous membrane of the stomach and markedly decreasing ulcer density. The antiulcerogenic effect of the dry aspen bar extract is comparable to that of the reference drugs alanton and gastrozepin.
Asunto(s)
Antiulcerosos/uso terapéutico , Extractos Vegetales/uso terapéutico , Úlcera Gástrica/prevención & control , Árboles/química , Animales , Antiinflamatorios no Esteroideos , Antiulcerosos/química , Evaluación Preclínica de Medicamentos , Histamina , Masculino , Pirenzepina/uso terapéutico , Extractos Vegetales/química , Quinolinas , Ratas , Ratas Wistar , Úlcera Gástrica/inducido químicamenteRESUMEN
The antiulcerogenic activity of aspen bark extract was demonstrated in experiments on a model of gastric ulcer in rats. Treatment with a 100 mg/kg dose of aspen bark extract led to decrease in the size and more active healing of the ulcerous defect in all follow-up periods.
Asunto(s)
Antiulcerosos/uso terapéutico , Fitoterapia , Estructuras de las Plantas/uso terapéutico , Úlcera Gástrica/tratamiento farmacológico , Árboles , Ácido Acético , Animales , Enfermedad Crónica , Modelos Animales de Enfermedad , Evaluación Preclínica de Medicamentos , Femenino , Extractos Vegetales/uso terapéutico , Ratas , Ratas Wistar , Estómago/efectos de los fármacos , Estómago/patología , Úlcera Gástrica/inducido químicamente , Úlcera Gástrica/patología , Factores de TiempoRESUMEN
Screening tests on mice with the use of a model of neurogenic damage to the stomach revealed antiulcerative activity in extracts of Amoor cork tree, Pacific Bergenia, Lespedeza dichromatic, Leuzea carthamoides, sea-buckthorn, common aspen, Manchurian nuts, Serratula coronarius, and Scutellaria baicalensis. It was proved that an extract of aspen cork produces a marked antiulcerative effect on being administered to animals with "acute" ulcers and in treatment of chronic peptic ulcer. The study of various drug forms of Serratula coronarius extracts (prepared from the bark and the bark and shoots) in experiments on mice (neurogenic ulcer) and rats (Aspirin ulcer) revealed the most marked gastroprotective effect of oil extracts of bark and shoots. A high antiulcerogenic activity of extracts prepared from grass and roots of Scutellaria baicalensis was demonstrated.
Asunto(s)
Antiulcerosos/uso terapéutico , Plantas Medicinales , Animales , Antiinflamatorios no Esteroideos , Aspirina , Modelos Animales de Enfermedad , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Ratones , Extractos Vegetales/uso terapéutico , Ratas , Restricción Física , Siberia , Úlcera Gástrica/tratamiento farmacológico , Úlcera Gástrica/etiologíaRESUMEN
The effect of liquid aspen bark extract on the effectiveness of cytostatic and surgical methods of treatment of experimental tumors in mice was studied. The extract was found to raise the antitumorous and antimetastatic effects of the above indicated methods of treatment on the tumor process.
Asunto(s)
Antineoplásicos Fitogénicos/uso terapéutico , Neoplasias Experimentales/tratamiento farmacológico , Fitoterapia , Árboles , Animales , Antineoplásicos Alquilantes/uso terapéutico , Terapia Combinada , Ciclofosfamida/uso terapéutico , Ensayos de Selección de Medicamentos Antitumorales , Sinergismo Farmacológico , Femenino , Masculino , Ratones , Ratones Endogámicos C57BL , Trasplante de Neoplasias , Neoplasias Experimentales/cirugía , Extractos Vegetales/uso terapéutico , Estadísticas no ParamétricasRESUMEN
Marked antiulcerative properties of a Populus tremula bark extract were demonstrated in experiments on mice and rats with stress-, reserpine-induced, and acetylsalicylic ulcers. The gastroprotective activity of the extract was expressed in decrease in the number of animals with mucosal ulcers and in marked decrease in the number of ulcers. It exceeded similar parameters of alanton, plantaglucide, and Hippopheae oil.