RESUMEN
UNLABELLED: Non-Hodgkin lymphoma is the most common primary testicular neoplasm of older men but is rare in young men. The vast majority of primary testicular lymphomas (PTL) are intermediate- to high-grade lymphomas. OBJECTIVE: To describe the clinical, morphologic, and immunophenolypic characteristics of PTL seen in a referral center. MATERIAL AND METHODS: We reviewed the cases of PTL seen from 1986 to 1999. We obtained data of laboratory, tests, clinical course, treatment, and immunohistochemical studies. RESULTS: 10 patients with diagnosis of PTL were identified. Median age was 62.3 years (range 42-81 years), and nine patients underwent orchiectomy as initial therapeutic procedure. Other treatment modalities after diagnosis included combination chemotherapy (60%) and combination radiotherapy (20%). Histologically, testes showed diffuse dense infiltration of large lymphoma cells. All cases were classified as diffuse large cell lymphoma according to REAL classification. Eight cases were studied with use of paraffin-section immunoperoxidase, 7/8 tumors were B-lineage lymphomas, and one was a T-lineage lymphoma.
Asunto(s)
Linfoma de Células B Grandes Difuso/patología , Neoplasias Testiculares/patología , Adulto , Anciano , Anciano de 80 o más Años , Humanos , Masculino , Persona de Mediana EdadRESUMEN
El linfoma no-Hodgkin (LNH) es la neoplasia testicular más común en hombres viejos y rara en hombres jóvenes. La gran mayoría de los linfomas primarios de testículo (LPT) es clasificada como linfomas de grado intermedio o alto. Objetivo: describir las características clínicas, morfológicas e inmunofenotípicas de los LPT atendidos en un hospital de referencia. Material y métodos: de 1986 a 1999 se revisaron los casos de LPT. Se analizaron los datos clínicos, estudios de laboratorio, evolución, tratamiento y se realizaron cortes en blanco para estudios de inmunohistoquímica (IH). Resultados: se incluyeron 10 pacientes con diagnóstico de LPT. El promedio de edad fue de 62.3 años (margen 42-81), en nueve pacientes se realizó orquiectomía como modalidad terapéutica inicial. Otros tratamientos posteriores al diagnóstico fueron; quimioterapia (60%) y radioterapia (20%). Histológicamente, los testículos mostraron infiltración difusa por células grandes de estirpe linfoide. Basados en la clasificación de la REAL, todos los casos fueron clasificados como linfomas difusos de células grandes. En ocho casos se realizó estudio de IH; 7/8 tumores expresaron inmunofenotipo B y sólo un caso inmunofenotipo T.
Non-Hodgkin lymphoma is the most common primary testicular neoplasm of older men but is rare in young men. The vast majority of primary testicular lymphomas (PTL) are intermediate- to high-grade lymphomas. Objective: to describe the clinical, morphologic, and immunophenotypic characteristics of PTL seen in a referral center. Material and Methods: we reviewed the cases of PTL seen from 1986 to 1999. We obtained data of laboratory tests, clinical course, treatment, and immunohistochemical studies. Results: 10 patients with diagnosis of PTL were identified. Median age was 62.3 years (range 42-81 years), and nine patients underwent orchiectomy as initial therapeutic procedure. Other treatment modalities after diagnosis included combination chemotherapy (60%) and combination radiotherapy (20%). Histologically, testes showed diffuse dense infiltration of large lymphoma cells. All cases were classified as diffuse large cell lymphoma according to REAL classification. Eight cases were studied with use of paraffin-section immunoperoxidase, 7/8 tumors were B-lineage lymphomas, and one was a T-lineage lymphoma.