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BACKGROUND: The aim of this study was to evaluate the efficacy of autologous fat graft with different surgical repair methods on reconstruction of a 10-mm-long rat sciatic nerve defect model. METHODS: One hundred forty-four sciatic nerves were operated on in 72 Wistar rats. The right limbs were assigned as group A (n = 72) and the left limbs as group B (n = 72). In group B, autologous fat graft was added to the surgical area so as to stay in contact with the coaptation site. Nerve regeneration was evaluated by walking track analysis, Sciatic Functional Index, pin-prick, and electrophysiologic and histologic tests at commencement and at 4 and 12 weeks after the operation. RESULTS: The rats receiving fat graft showed better regeneration, but the difference was only significant according to Sciatic Functional Index and pin-prick test (p < 0.05). Primary repair, autogenous nerve graft, acellularized nerve graft, vein filled with fresh and denatured muscle graft subgroups in group B showed significantly better regeneration than those in group A according to the Sciatic Functional Index (p < 0.05). In terms of latency and amplitude, all subgroups in groups A and B were found significantly different from the commencement of the study, but there was no difference between groups A and B (p < 0.05). CONCLUSIONS: Although there was no significant difference between the groups, rats receiving autologous fat graft showed better regeneration. Combined use of autologous fat graft with surgical repair methods induced significantly better regeneration. It was concluded that autologous fat grafting may have a beneficial effect on nerve regeneration when it is present in the coaptation site during healing.

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BACKGROUND: Angular artery, lateral nasal artery, and infraorbital artery pedicled nasolabial flaps have been used for reconstruction of lower nose and medial cheek defects. An alternative pedicle to raise a flap in the nasolabial area is the superior labial artery. Superior labial artery is a constant branch of the facial artery, arising above or at the angle of mouth and anastomoses with its counterpart in the middle of the upper lip. This makes a reverse superior labial artery pedicle possible for elevation of a nasolabial flap. PATIENTS AND METHODS: Reverse superior labial artery island flaps were used for reconstruction of lower nose and medial cheek defects in 12 patients. Eleven patients presented with malignant skin lesions and 1 with a traumatic defect of the lower nose. Auricular cartilage graft to support the alar rim and nasal tip was combined to the flap in 3 patients. RESULTS: All flaps survived completely. Temporary venous congestion was observed in 3 flaps in the early postoperative period but this resolved in 3 to 5 days. All patients healed without any postoperative complications and the final results were considered satisfactory. CONCLUSIONS: Reverse superior labial artery pedicled nasolabial island flap proved to be a good choice for reconstruction of the lower nose and moderate sized medial cheek defects. This pedicle should be considered where the defect is located on the course of lateral nasal artery or angular artery. Arc of rotation and reliability of this new flap is considered superior to angular artery and infraorbital artery-based nasolabial flaps where these arteries could also be used as pedicle.

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The pathology of "nasal tip complex" remains as a problem to be solved in unilateral cleft lip nose deformity wherein open rhinoplasty and cartilage grafts are used frequently. For this reason, the research for the treatment of cleft-side tip projection lost and ala depression still continues. Our technique is to put the cartilage graft at posterior dome area after the release of cleft-side ala from vestibular mucosa and skin to elevate the ala depression and tip projection. This technique has been used on 16 patients between the years 2003 and 2007. This technique, different from the augmentation methods, aims to increase the direct lateral crura's elastic support strength and to support the new position of alar cartilage. This method will particularly be helpful in obtaining the long-term results in delayed and serious cases.

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BACKGROUND: The superiorly based nasolabial flap is a well-known procedure. However, random pattern or subcutaneous pedicle flaps are insufficient for reconstruction of large defects. Artery pedicle flaps have a satisfactory blood supply, and for that reason, the required tissue can be raised for reconstruction of large defects of the nose. METHODS: Twelve cases were operated on with this technique. Reconstruction was performed with a lateral nasal artery pedicle island flap. The mean age of the patients was 68.4 years. Three patients required cartilage grafts for alar rim support. The cartilage grafts were harvested from the auricular conchal bowl. The follow-up period ranged from 15 to 33 months. RESULTS: There was no partial or total loss of the flap. There was no distortion on the face caused by smiling and pursing of the lips observed. Donor and reconstructed areas have an excellent appearance in all cases. The aesthetic results were satisfying for all patients as well. CONCLUSIONS: The authors' flap can be used for reconstructing large defects of the lower half of the nose, and reconstruction with a single stage yields a fast and satisfactory result. The authors advocate that the lateral nasal artery pedicle nasolabial island flap is an excellent choice for reconstruction of large defects in the lower half of the nose.

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