RESUMEN

Simultaneous levels of thrombin and its natural antibodies were comparatively analyzed in donors and patients with myocardial infarction. Thrombin and its antibody levels were demonstrated to remain unchanged in the healthy subjects. With myocardial infarction development, there was an increase in thrombin concentrations and a decrease in natural antithrombin antibodies at the same time. A linear correlation was established between the levels of thrombin and its antibodies and failure in diagnosing coagulative disorders by one of the parameters studied was also ascertained, which made it possible to introduce a new diagnostic criterion, namely an "antithrombin index" that enabled the groups of donors and patients to be differentiated.

Asunto(s)

Autoanticuerpos/análisis , Donantes de Sangre , Infarto del Miocardio/sangre , Trombina/análisis , Adulto , Anciano , Autoanticuerpos/inmunología , Femenino , Humanos , Síndromes de Inmunodeficiencia/etiología , Masculino , Persona de Mediana Edad , Infarto del Miocardio/inmunología , Trombina/inmunología , Trombosis/etiología