RESUMEN

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.

Asunto(s)

Adhesión Bacteriana/fisiología , Burkholderia pseudomallei/metabolismo , Proteínas Fimbrias/metabolismo , Fimbrias Bacterianas/metabolismo , Animales , Adhesión Bacteriana/genética , Burkholderia pseudomallei/genética , Burkholderia pseudomallei/patogenicidad , Caenorhabditis elegans/metabolismo , Caenorhabditis elegans/microbiología , Células Cultivadas , Células Epiteliales/metabolismo , Células Epiteliales/microbiología , Fimbrias Bacterianas/genética , Humanos , Ratones , Factores de Tiempo