RESUMEN
Results are submitted of employment of intraarterial superselective polychemotherapy in the treatment of malignant tumors of female genital organs in 106 patients; of these, forty individuals presented with carcinoma of the neck of the womb, 33 with tumours of the trophoblast, 18 had carcinoma of the ovaries, and 15 carcinoma of the body of the womb. A clinical analysis was done of the results obtained as were clinical-morphological correspondences (there has been studied a therapeutic pathomorphosis of the tumours) depending on the disease stage, individual schemes of polychemotherapy. The greatest benefit from the above treatment occurred in proliferative and invasive vascular mole and choriocarcinoma; patients with carcinoma of the neck and body of the womb derived less benefit, those with carcinoma of the ovaries experienced the least therapeutic effect. Intraarterial polychemotherapy permits the generative function to be preserved in trophoblast disease, the percentage of operability to be raised in carcinoma of the neck and body of the womb.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación , Neoplasias de los Genitales Femeninos/tratamiento farmacológico , Quimioterapia Adyuvante/métodos , Femenino , Neoplasias de los Genitales Femeninos/patología , Humanos , Infusiones Intraarteriales , Estadificación de Neoplasias , Cuidados Posoperatorios/métodos , Cuidados Preoperatorios/métodos , Factores de Tiempo , Resultado del TratamientoRESUMEN
Local intracavitary hyperthermia and simultaneous intensive-concentrated irradiation were used in 23 patients with esophageal cancer and 64 cases of cardioesophageal malignancy prior to surgery. The procedure for thermometry is described. Hyperthermia was carried out after the second and fifth (out of six) radiation fractions, thermotolerability being taken into account. Complete and partial response rate was 72.7% in the study group compared to 56.5% in controls. The volume fraction of viable parenchyma dropped to 2.1 +/- 0.2% (16.6 +/- 1.5% in controls) whereas the injury index according to Lavnikova rose to 95.0% (58.7% in controls).