1.
J Pharmacol Pharmacother
; 5(3): 193-6, 2014 Jul.
Artículo
en Inglés
| MEDLINE
| ID: mdl-25210399
RESUMEN
OBJECTIVE: To explore the effect of sequential treatment with glucocorticoid and tumor necrosis factor-alpha inhibitors in patients with Takayasu arteritis (TA). MATERIALS AND METHODS: In five patients with TA, the effects of the sequential treatment with prednisone for 5-7 months and then with adalimumab (ADA) + methotrexate (MTX) or infliximab + MTX, or with ADA only, for 12 months on both clinical and laboratory findings were evaluated. RESULTS: All treatments improved both symptoms and laboratory parameters without the development of side-effects. CONCLUSIONS: It was hypothesized that MMP-9 and neutrophil gelatinase-associated lipocalin could be markers of the response to the treatments.