RESUMEN

PURPOSE: To assess whether health-related quality of life (HRQOL) improved through a postmastectomy care program focused on breast cancer-related lymphedema (BCRL) protection/awareness. METHODS: Postoperative breast cancer patients were enrolled prospectively (February-2018 to September-2019) at Nursing and Obstetrics Faculty, Durango, Mexico. Sociodemographic/clinical characteristics, arm measurements, and HRQOL evaluation with Functional Assessment Cancer Therapy-Breast Cancer were collected at baseline and after six follow-up assessments between six-to-twelve-month postmastectomy. Lymphedema was verified through circometry. Descriptive analysis and McNemar-Bowker test were used to evaluate paired differences in HRQOL. Subgroup analysis was conducted to assess sociodemographic/clinical characteristics of BCRL using Pearson's chi-squared or Fisher exact test along with odds ratios (OR) and 95% confidence intervals (CI). All tests were two-sided with P-values < 0.05 considered statistically significant. RESULTS: One-hundred-two patients developed BCRL (incidence 66.2%, n = 154). All dimensions of HRQOL improved after the postmastectomy care program (P < 0.05). The subgroup analysis indicated that elementary academic degree (OR = 2.40, 95%CI: 1.01-5.69), laborer (OR = 9.85, 95%CI: 3.30-29.3), and total mastectomy (OR = 4.23, 95%CI: 1.20-14.9) were more associated with BCRL (P < 0.05). Conversely, high school academic degree (OR = 0.46, 95%CI: 0.22-0.94), married status (OR = 0.42, 95%CI: 0.21-0.86), housewife (OR = 0.27, 95%CI: 0.12-0.61), professional occupation (OR = 0.10, 95%CI: 0.01-0.64), and having no comorbidities (OR = 0.31, 95%CI: 0.15-0.63) were less associated with BCRL (P < 0.05). CONCLUSION: Although HRQOL improved through the postmastectomy care program, our findings suggest that lower education, working as a laborer, and total mastectomy may be more associated with BCRL. Continuing research may uncover liabilities among BCRL patients within limited-resources settings.

Asunto(s)

Mastectomía , Calidad de Vida , Humanos , Femenino , Estudios Prospectivos , México , Persona de Mediana Edad , Mastectomía/efectos adversos , Adulto , Anciano , Linfedema del Cáncer de Mama/etiología , Linfedema del Cáncer de Mama/terapia , Neoplasias de la Mama/cirugía , Neoplasias de la Mama/complicaciones

RESUMEN

Introduction: Oral transmission of T. cruzi is probably the most frequent transmission mechanism in wild animals. This observation led to the hypothesis that consuming raw or undercooked meat from animals infected with T. cruzi may be responsible for transmitting the infection. Therefore, the general objective of this study was to investigate host-pathogen interactions between the parasite and gastric mucosa and the role of meat consumption from infected animals in the oral transmission of T. cruzi. Methods: Cell infectivity assays were performed on AGS cells in the presence or absence of mucin, and the roles of pepsin and acidic pH were determined. Moreover, groups of five female Balb/c mice were fed with muscle tissue obtained from mice in the acute phase of infection by the clone H510 C8C3hvir of T. cruzi, and the infection of the fed mice was monitored by a parasitemia curve. Similarly, we assessed the infective capacity of T. cruzi trypomastigotes and amastigotes by infecting groups of five mice Balb/c females, which were infected orally using a nasogastric probe, and the infection was monitored by a parasitemia curve. Finally, different trypomastigote and amastigote inoculums were used to determine their infective capacities. Adhesion assays of T. cruzi proteins to AGS stomach cells were performed, and the adhered proteins were detected by western blotting using monoclonal or polyclonal antibodies and by LC-MS/MS and bioinformatics analysis. Results: Trypomastigote migration in the presence of mucin was reduced by approximately 30%, whereas in the presence of mucin and pepsin at pH 3.5, only a small proportion of parasites were able to migrate (∼6%). Similarly, the ability of TCTs to infect AGS cells in the presence of mucin is reduced by approximately 20%. In all cases, 60-100% of the animals were fed meat from mice infected in the acute phase or infected with trypomastigotes or amastigotes developed high parasitemia, and 80% died around day 40 post-infection. The adhesion assay showed that cruzipain is a molecule of trypomastigotes and amastigotes that binds to AGS cells. LC-MS/MS and bioinformatics analysis, also confirmed that transialidase, cysteine proteinases, and gp63 may be involved in TCTs attachment or invasion of human stomach cells because they can potentially interact with different proteins in the human stomach mucosa. In addition, several human gastric mucins have cysteine protease cleavage sites. Discussion: Then, under our experimental conditions, consuming meat from infected animals in the acute phase allows the T. cruzi infection. Similarly, trypomastigotes and amastigotes could infect mice when administered orally, whereas cysteinyl proteinases and trans-sialidase appear to be relevant molecules in this infective process.

Asunto(s)

Enfermedad de Chagas , Enfermedades Transmisibles , Trypanosoma cruzi , Femenino , Animales , Ratones , Humanos , Trypanosoma cruzi/metabolismo , Pepsina A/metabolismo , Parasitemia , Modelos Animales de Enfermedad , Cromatografía Liquida , Espectrometría de Masas en Tándem , Enfermedad de Chagas/parasitología , Mucinas

RESUMEN

Intrasaccular flow disruption is a viable alternative to other endovascular treatments for saccular or wide-necked bifurcation intracranial aneurysms; however, wide neck aneurysms with irregular shapes or shallow depth may not be amenable to treatment currently available intrasaccular devices. Here, we present the first ever case report of the novel Saccular Endovascular Aneurysm Lattice Embolization System (SEAL™). The versatile utility of the SEAL™ device is demonstrated in a patient with acute subarachnoid hemorrhage (SAH) from a ruptured, complex, left middle cerebral artery (MCA) trilobed shallow wide-necked bifurcation aneurysm. Deployment and implantation of the SEAL device were technically feasible, safe, and conformed well to the irregular shape of the complex, ruptured aneurysm. Immediate total aneurysm occlusion was observed after implantation. Importantly, 1-year angiographic follow-up demonstrated durable, complete occlusion with no safety concerns. The SEAL device is a promising new novel technology which has the potential to treat very shallow aneurysms with limited height and irregular, multilobulated aneurysms.

Asunto(s)

Aneurisma Roto , Aneurisma de la Aorta Abdominal , Implantación de Prótesis Vascular , Embolización Terapéutica , Procedimientos Endovasculares , Aneurisma Intracraneal , Humanos , Aneurisma Intracraneal/terapia , Aneurisma Intracraneal/cirugía , Estudios de Seguimiento , Resultado del Tratamiento , Aneurisma de la Aorta Abdominal/cirugía , Estudios Retrospectivos , Procedimientos Endovasculares/métodos , Aneurisma Roto/terapia , Aneurisma Roto/cirugía , Embolización Terapéutica/métodos , Angiografía Cerebral

RESUMEN

<b><br>Introduction:</b> Acute appendicitis is one of the most frequent emergencies in hospitals around the world; it requires early surgical treatment in complicated cases. One of the challenges that the surgeon faces during appendectomy is when the base of the appendix is compromised by either a perforation or gangrene. To show the surgical strategies that have been reported, as well as the complications associated with a compromised appendicular base in a complicated acute appendicitis.</br> <b><br>Methods:</b> A bibliographic search was carried out in the databases of Pubmed, Embase, Web of Science, and Google Scholar. The search expression ("appendiceal stump closure" OR "Closure of the appendiceal stump" OR "Management of appendiceal stump") was used to search for articles. The inclusion criteria were observational studies (case reports, case series, or cross-sectional, case-control, or cohort studies).</br> <b><br>Discussion:</b> Different techniques have been reported for the treatment of a compromised appendicular base. Among the most used are primary closure, partial resection of the cecum, cecostomy tube, ileocecectomy, and right hemicolectomy. The most frequent complications are surgical site infection, intra-abdominal abscess, postoperative ileus, intestinal obstruction, and others.</br> <b><br>Conclusions:</b> The appendicular base, compromised by necrosis or perforation, requires adequate treatment in order to prevent dehiscence of the appendicular stump sutures and fecal peritonitis. A number of surgical options have been reported.</br>.

Asunto(s)

Apendicitis , Apéndice , Laparoscopía , Humanos , Apendicitis/complicaciones , Apendicitis/cirugía , Estudios Transversales , Laparoscopía/métodos , Apéndice/cirugía , Apendicectomía/métodos , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/cirugía

RESUMEN

Throughout the years, wildfires have negatively impacted ecological systems and urban areas. Hence, reinforcing territorial risk management strategies against wildfires is essential. In this study, we built an early alert system (EAS) with two different Machine Learning (ML) techniques to calculate the meteorological conditions of two Colombian areas: (i) A 3D convolutional neural net capable of learning from satellite data and (ii) a convolutional network to bias-correct the Weather Research and Forecasting (WRF) model output. The results were used to quantify the daily Fire Weather Index and were coupled with the outcomes from a land cover analysis conducted through a Naïve-Bayes classifier to estimate the probability of wildfire occurrence. These results, combined with an assessment of global vulnerability in both locations, allow the construction of daily risk maps in both areas. On the other hand, a set of short-term preventive and corrective measures were suggested to public authorities to implement, after an early alert prediction of a possible future wildfire. Finally, Soil Management Practices are proposed to tackle the medium- and long-term causes of wildfire development, with the aim of reducing vulnerability and promoting soil protection. In conclusion, this paper creates an EAS for wildfires, based on novel ML techniques and risk maps.

Asunto(s)

Incendios , Incendios Forestales , Teorema de Bayes , Tiempo (Meteorología) , Suelo

RESUMEN

Quorum sensing (QS) and type III secretion systems (T3SSs) are among the most attractive anti-virulence targets for combating multidrug-resistant pathogenic bacteria. Some halogenated furanones reduce QS-associated virulence, but their role in T3SS inhibition remains unclear. This study aimed to assess the inhibition of these two systems on Pseudomonas aeruginosa virulence. The halogenated furanones (Z)-4-bromo-5-(bromomethylene)-2(5H) (C-30) and 5-(dibromomethylene)-2(5H) (named hereafter GBr) were synthesized, and their ability to inhibit the secretion of type III exoenzymes and QS-controlled virulence factors was analyzed in P. aeruginosa PA14 and two clinical isolates. Furthermore, their ability to prevent bacterial establishment was determined in a murine cutaneous abscess model. The GBr furanone reduced pyocyanin production, biofilm formation, and swarming motility in the same manner or more effectively than C-30. Moreover, both furanones inhibited the secretion of ExoS, ExoT, or ExoU effectors in all tested strains. The administration of GBr (25 and 50 µM) to CD1 mice infected with the PA14 strain significantly decreased necrosis formation in the inoculation zone and the systemic spread of bacteria more efficiently than C-30 (50 µM). Molecular docking analysis suggested that the gem position of bromine in GBr increases its affinity for the active site of the QS LasR regulator. Overall, our findings showed that the GBr furanone displayed efficient multi-target properties that may favor the development of more effective anti-virulence therapies.

RESUMEN

Abstract Coronavirus disease 2019 (COVID-19) produces a significant burden to severely ill patients affected by acute respiratory failure. The aim of this study was to describe echocardiographic findings in a series of mechanically ventilated patients with moderate and severe acute respiratory distress syndrome (ARDS) due to COVID-19. This was a single center, descriptive and cros s-sectional study of prospectively collected data. Patients had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and moderate or severe ARDS. Initial echocardiogram was performed within 7 days of intensive care unit admission and every 15 days until mechanical ventilation ended, 28 days or death. Time spent by the physician for each study was measured. Multiple echographic measurements were acquired; 33 patients were analyzed. Total number of echocardiograms performed was 76. The median imaging time required to complete a standard study was 13 [10-15] minutes. Chronic structural abnormalities were present in 16 patients (48%), being LV hypertrophy the main finding in 11 patients (33%). The most frequent acute or dynamic finding was RV enlargement (43%) when considering all echocardiograms performed from admission to day 28 of follow-up. Other findings were: pulmonary hypertension (15%), new or dynamic left ventricle (LV) regional wall motion abnormalities (15%), new or dynamic LV global contractility deterioration (6%) and hypercontractility (12%).

---

Resumen La enfermedad por coronavirus 2019 (COVID-19) produce una carga significativa para los pacientes gravemente enfermos afectados por insuficiencia respiratoria aguda. El objetivo de este estudio fue describir los hallazgos ecocardiográficos en una serie de pacientes ventilados mecánicamente con síndrome de dificultad respiratoria aguda (SDRA) moderado y grave debido a COVID-19. Se trata de un estudio unicéntrico, descriptivo y de corte transversal de datos recopilados en forma prospectiva. Los pacientes tenían una infección por el coronavirus SARS-Cov-2 y SDRA moderado o grave. El ecocardiogra ma inicial se realizó dentro de los 7 días del ingreso en la unidad de cuidados intensivos y luego cada 15 días hasta finalizar la ventilación mecánica, 28 días o fallecimiento. Se midió el tiempo empleado por el operador en cada estudio. Se adquirieron múltiples medidas ecográficas. Se analizaron 33 pacientes. El número total de ecocardiogramas realizados fue de 76. El tiempo necesario (mediana [RIQ]) para la obtención de las imágenes de un estudio estándar fue de 13 [10-15] minutos. Las anomalías estructurales crónicas estuvieron presentes en 16 pacientes (48%), siendo la hipertrofia ventricular izquierda la principal (11 pacientes, 33%). El hallazgo agudo o dinámico más frecuente fue el agrandamiento del ventrículo derecho (VD) (43%) al considerar todos los ecocardiogramas realizados desde el ingreso hasta el día 28 de seguimiento. Otros hallazgos fueron: hipertensión pulmonar (15%), anomalías del movimiento de la pared regional del VI nuevas o dinámicas (15%), deterioro de la contractilidad global del ventrículo izquierdo, nuevo o dinámico (6%), e hipercontractilidad (12%).

RESUMEN

Coronavirus disease 2019 (COVID-19) produces a significant burden to severely ill patients affected by acute respiratory failure. The aim of this study was to describe echocardiographic findings in a series of mechanically ventilated patients with moderate and severe acute respiratory distress syndrome (ARDS) due to COVID-19. This was a single center, descriptive and cros s-sectional study of prospectively collected data. Patients had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and moderate or severe ARDS. Initial echocardiogram was performed within 7 days of intensive care unit admission and every 15 days until mechanical ventilation ended, 28 days or death. Time spent by the physician for each study was measured. Multiple echographic measurements were acquired; 33 patients were analyzed. Total number of echocardiograms performed was 76. The median imaging time required to complete a standard study was 13 [10-15] minutes. Chronic structural abnormalities were present in 16 patients (48%), being LV hypertrophy the main finding in 11 patients (33%). The most frequent acute or dynamic finding was RV enlargement (43%) when considering all echocardiograms performed from admission to day 28 of follow-up. Other findings were: pulmonary hypertension (15%), new or dynamic left ventricle (LV) regional wall motion abnormalities (15%), new or dynamic LV global contractility deterioration (6%) and hypercontractility (12%).

---

La enfermedad por coronavirus 2019 (COVID-19) produce una carga significativa para los pacientes gravemente enfermos afectados por insuficiencia respiratoria aguda. El objetivo de este estudio fue describir los hallazgos ecocardiográficos en una serie de pacientes ventilados mecánicamente con síndrome de dificultad respiratoria aguda (SDRA) moderado y grave debido a COVID-19. Se trata de un estudio unicéntrico, descriptivo y de corte transversal de datos recopilados en forma prospectiva. Los pacientes tenían una infección por el coronavirus SARS-Cov-2 y SDRA moderado o grave. El ecocardiograma inicial se realizó dentro de los 7 días del ingreso en la unidad de cuidados intensivos y luego cada 15 días hasta finalizar la ventilación mecánica, 28 días o fallecimiento. Se midió el tiempo empleado por el operador en cada estudio. Se adquirieron múltiples medidas ecográficas. Se analizaron 33 pacientes. El número total de ecocardiogramas realizados fue de 76. El tiempo necesario (mediana [RIQ]) para la obtención de las imágenes de un estudio estándar fue de 13 [10-15] minutos. Las anomalías estructurales crónicas estuvieron presentes en 16 pacientes (48%), siendo la hipertrofia ventricular izquierda la principal (11 pacientes, 33%). El hallazgo agudo o dinámico más frecuente fue el agrandamiento del ventríc ulo derecho (VD) (43%) al considerar todos los ecocardiogramas realizados desde el ingreso hasta el día 28 de seguimiento. Otros hallazgos fueron: hipertensión pulmonar (15%), anomalías del movimiento de la pared regional del VI nuevas o dinámicas (15%), deterioro de la contractilidad global del ventrículo izquierdo, nuevo o dinámico (6%), e hipercontractilidad (12%).

Asunto(s)

COVID-19 , Síndrome de Dificultad Respiratoria , Ecocardiografía , Humanos , Respiración Artificial , Síndrome de Dificultad Respiratoria/diagnóstico por imagen , Síndrome de Dificultad Respiratoria/terapia , SARS-CoV-2

RESUMEN

Antimicrobial resistance is one of the current public health challenges to be solved. The World Health Organization (WHO) has urgently called for the development of strategies to expand the increasingly limited antimicrobial arsenal. The development of anti-virulence therapies is a viable option to counteract bacterial infections with the possibility of reducing the generation of resistance. Here we report on the chemical structures of pyrrolidones DEXT 1-4 (previously identified as furan derivatives) and their anti-virulence activity on Pseudomonas aeruginosa strains. DEXT 1-4 were shown to inhibit biofilm formation, swarming motility, and secretion of ExoU and ExoT effector proteins. Also, the anti-pathogenic property of DEXT-3 alone or in combination with furanone C-30 (quorum sensing inhibitor) or MBX-1641 (type III secretion system inhibitor) was analyzed in a model of necrosis induced by P. aeruginosa PA14. All treatments reduced necrosis; however, only the combination of C-30 50 µM with DEXT-3 100 µM showed significant inhibition of bacterial growth in the inoculation area and systemic dispersion. In conclusion, pyrrolidones DEXT 1-4 are chemical structures capable of reducing the pathogenicity of P. aeruginosa and with the potential for the development of anti-virulence combination therapies.

Asunto(s)

Antibacterianos , Furanos , Hidrocarburos Halogenados , Infecciones por Pseudomonas , Pseudomonas aeruginosa , Pirrolidinonas , Sistemas de Secreción Tipo III/antagonistas & inhibidores , Animales , Antibacterianos/química , Antibacterianos/farmacología , Furanos/química , Furanos/farmacología , Humanos , Hidrocarburos Halogenados/química , Hidrocarburos Halogenados/farmacología , Ratones , Necrosis , Infecciones por Pseudomonas/tratamiento farmacológico , Infecciones por Pseudomonas/metabolismo , Pseudomonas aeruginosa/crecimiento & desarrollo , Pseudomonas aeruginosa/patogenicidad , Pirrolidinonas/química , Pirrolidinonas/farmacología , Percepción de Quorum/efectos de los fármacos , Sistemas de Secreción Tipo III/metabolismo , Factores de Virulencia/metabolismo

RESUMEN

Este artículo compara los determinantes sociales de la salud (DSS) entre los departamentos del Noroeste Argentino que poseen alto riesgo de mortalidad infantil neonatal o pos-neonatal reducible y el resto de ellos, entre los años 2010 y 2014. El análisis de las condiciones socioeconómicas y su vínculo con la mortalidad infantil aporta conocimiento necesario respecto a la importancia de la consideración del entorno de las poblaciones y resulta imprescindible para formular políticas públicas adecuadas. Se propone un estudio ecológico con datos censales de 2010 y estadísticas vitales. Se identifican los departamentos de alto riesgo de muerte mediante el software libre SaTScan. Luego, se realiza una prueba T de comparación de medias para muestras independientes. De esta forma, se identificaron mayores deficiencias en los DSS de las zonas con alto riesgo

---

We aim to compare the social determinants of health (DSS) between the departments of the Argentine Northwest with a high risk of reducible neonatal and postneonatal infant mortality and the rest of them, between 2010 and 2014. Consideration of socioeconomic conditions and their link with infant mortality provides essential knowledge regarding the importance of considering the environment of populations and is essential for formulating adequate public policies. An ecological study is proposed, with census data from 2010, and vital statistics. Departments at high risk of death are identified using free Satscan software, and then a mean comparison t-test is performed for independent samples. Greater deficiencies were identified in the DSS in high-risk areas

Asunto(s)

Humanos , Mortalidad Infantil , Determinantes Sociales de la Salud , Análisis Espacial

RESUMEN

It is central to the management of patients with Medication-overuse headache that they reverse their behavior regarding the frequent use of pain medication. The objective of this study was to compare two counseling techniques for treating patients with Medication-overuse headache (MOH). This was a randomized, blind, controlled clinical trial that compared a structured (FRAMES) and unstructured counseling, for the treatment of MOH. Patients were assessed before the counseling and then again four and eight weeks after it. Semi-structured interview, headache diary, the Headache Impact Test (HIT-6) and the Hospital Anxiety and Depression Scale were used. Primary endpoints were the following: number of patients who stopped medication overuse; days with acute medication use; HIT-6; the number of patients who returned for consultations. Secondary endpoints were as follows: days per month of headache; 50% reduction in monthly days with acute medication use; the number of patients with less than 15 days of headache. Thirty-seven patients were allocated to the "FRAMES Group" and 33 to the "Control Group". There was no difference regarding primary or secondary outcomes between the two groups. There was a significant reduction in the frequency of headache and the number of days using pain medication in the first and second months of follow-up compared to baseline in both groups. There was a significant reduction in the HIT-6 in the first and second months of follow-up compared to baseline in the FRAMES Group, but not in the control group. Patients in both counseling groups significantly decreased the use of pain medications and the frequency of their headaches.

Asunto(s)

Consejo , Cefaleas Secundarias/terapia , Adulto , Anticonvulsivantes/uso terapéutico , Antidepresivos Tricíclicos/uso terapéutico , Femenino , Cefaleas Secundarias/tratamiento farmacológico , Humanos , Masculino , Persona de Mediana Edad , Topiramato/uso terapéutico , Resultado del Tratamiento

RESUMEN

The effort to understand the genetic basis of human sociality has been encouraged by the diversity and heritability of social traits like cooperation. This task has remained elusive largely because most studies of sociality and genetics use sample sizes that are often unable to detect the small effects that single genes may have on complex social behaviors. The lack of robust findings could also be a consequence of a poor characterization of social phenotypes. Here, we explore the latter possibility by testing whether refining measures of cooperative phenotypes can increase the replication of previously reported associations between genetic variants and cooperation in small samples. Unlike most previous studies of sociality and genetics, we characterize cooperative phenotypes based on strategies rather than actions. Measuring strategies help differentiate between similar actions with different underlaying social motivations while controlling for expectations and learning. In an admixed Latino sample (n = 188), we tested whether cooperative strategies were associated with three genetic variants thought to influence sociality in humans-MAOA-uVNTR, OXTR rs53576, and AVPR1 RS3. We found no association between cooperative strategies and any of the candidate genetic variants. Since we were unable to replicate previous observations our results suggest that refining measurements of cooperative phenotypes as strategies is not enough to overcome the inherent statistical power problem of candidate gene studies.

Asunto(s)

Conducta Cooperativa , Genotipo , Monoaminooxidasa/genética , Receptores de Oxitocina/genética , Receptores de Vasopresinas/genética , Adolescente , Adulto , Femenino , Juegos Experimentales , Humanos , Masculino , Polimorfismo Genético

RESUMEN

Resumen Introducción: En este trabajo se propone identificar las brechas en la tasa de mortalidad infantil (TMI), según el nivel de instrucción de las madres en las seis provincias del noroeste argentino (NOA), una región que se caracteriza por poseer indicadores sociodemográficos rezagados respecto al total del país. Metodología: Para estimar las TMI según nivel de instrucción de las madres se emplea el método de Brass con la variante propuesta por Hill. Se utilizan los datos del censo argentino de 2010. Además, se simula el nivel actual de la mortalidad infantil de acuerdo con los indicadores obtenidos. Resultados: La brecha entre la TMI de las mujeres con bajo y alto nivel de instrucción es entre dos y tres veces mayor, mientras que es entre una y dos veces al comparar las de nivel medio con las de alto. Si estas brechas se aplican a las TMI oficiales del año 2017, más de 10 defunciones infantiles por cada mil nacidos vivos corresponderían a mujeres de nivel medio o bajo. Conclusiones: Existe una desigualdad en la mortalidad infantil en el NOA, de acuerdo con la educación de las madres. De esta realidad se no escapan otras regiones del país ni del mundo. Si bien las estadísticas vitales intentan relevar algunos determinantes sociales de la salud, particularmente el nivel educativo de las personas, esta fuente aún no permite su aprovechamiento en el diagnóstico y seguimiento de desigualdades. Los métodos indirectos pueden complementar, cuando no suplir estas deficiencias, aun considerando sus propias limitaciones.

---

Abstract Introduction: This paper aims at identifying the gap in the Infant Mortality Rate (IMR) according to the mothers' education level in six provinces of the Argentinean Northwest (NOA). This is a region that is characterized by having sociodemographic indicators that lag behind the rest of the country. Methodology: In order to estimate the IMR according to the mothers' education level, the Brass method with Hill's variant is applied using data from the 2010 census. Moreover, the current infant mortality rate is simulated according to the obtained indicators. Results: The gap between the IMR of women with a lower education level and those with a higher education level is twice or three times higher, whereas the gap considering women of a middle education level and those of the highest level varies between one and two. If these gaps were applied to the official IMR from 2017, more than 10 infant deaths per one thousand of children born alive would correspond to women with middle or low education level. Conclusions: There is inequality in the infant mortality in the NOA region according to the education level of mothers, which is far from other regions in the country or the world. Even if vital statistics attempt at revealing some social determinants of health, especially the education level, this source cannot yet be fully used in the diagnostic and follow-up of said inequalities. Indirect methods, considering their own limitations, can complement these deficiencies.

Asunto(s)

Humanos , Mortalidad Infantil , Educación de la Población , Argentina

RESUMEN

BACKGROUND: An iliac artery aneurysm is a permanent and focal dilation of the artery that measures more than 50% of the normal diameter of the vessel. Isolated iliac artery aneurysms are infrequent, mostly as an association with an abdominal aortic aneurysm. The objective of this article is mainly to focus on urological symptoms as the manifestations of iliac artery aneurysm, to propitiate an early diagnosis. CLINICAL CASE: In this article, we present a clinical case of a patient with generalized weakness, an episode of lipothymia and pain in the renal fossa, finding three aneurysms in the computed tomography, located in the right common iliac artery, the left internal iliac artery and the left external iliac artery. Later, the patient presents urological complications, after an obstruction of the right ureter, and therefore, a right hydronephrosis and loss of renal parenchyma function. Given this, urgent surgery is performed with satisfactory results. CONCLUSIONS: The diagnosis of an iliac aneurism represents a challenge since most patients are asymptomatic. As main manifestation, urinary compression symptoms represented a fundamental part of diagnostic suspicion, which coincides with other similar cases reported in the literature.

---

INTRODUCCIÓN: Un aneurisma de arteria ilíaca es una dilatación permanente y focal de la arteria, de más del 50% del diámetro normal del vaso. Los aneurismas de arteria ilíaca aislados son infrecuentes, siendo lo más característico su asociación con un aneurisma de aorta abdominal. El objetivo de este artículo es puntualizar los síntomas urológicos como manifestaciones de aneurisma de arteria ilíaca, y así propiciar un diagnóstico oportuno. CASO CLÍNICO: Se expone caso de un paciente que presenta un cuadro de debilidad generalizada, episodios de lipotimia y dolor en la fosa renal, a quien se le dio abordaje inicial como probable litiasis renal, encontrándose tres aneurismas en la tomografía computada, localizados en las arterias ilíaca común derecha, ilíaca interna izquierda e ilíaca externa izquierda. Durante su estudio y discusión acerca de las alternativas terapéuticas, el paciente manifiesta complicaciones urológicas secundarias, tras una obstrucción de uréter derecho, y como consecuencia una hidronefrosis derecha y pérdida de la función del parénquima renal. Dado lo anterior, se realizó una cirugía de urgencia en conjunto con cirugía vascular y urología para la colocación de prótesis vasculares, así como nefrectomía derecha, la cual resulta en una evolución satisfactoria. CONCLUSIONES: El diagnóstico de un aneurisma ilíaco es un reto debido a que la mayoría de los pacientes son asintomáticos. Como manifestación principal, los síntomas urinarios por compresión fueron parte fundamental de la sospecha diagnóstica, lo que coincide con otros casos similares reportados en la literatura.

Asunto(s)

Aneurisma de la Aorta Abdominal , Aneurisma Ilíaco , Aorta Abdominal , Humanos , Aneurisma Ilíaco/diagnóstico por imagen , Aneurisma Ilíaco/cirugía , Arteria Ilíaca/diagnóstico por imagen , Riñón

RESUMEN

The importance of surveilling the circulation of the influenza virus and timely vaccination of different populations in Peru was analyzed in three sessions by a group of clinical experts from different specialties. The Peruvian national influenza surveillance system has many selected establishments that have become currently ineffective in terms of a timely report. Most of the samples come from Lima. The viral distribution is inadequately analyzed. The northern and jungle areas of the country have weather and season conditions different to those in Lima and on the southern highlands. This lack of coordination is accentuated by the opportunity of arrival of the influenza vaccine in the country. The Ministry of Health uses a trivalent vaccine but the possibility of a tetravalent vaccine with the two type-B lineages must be analyzed from a cost-benefit standpoint. The appropriateness of vaccinating two times a year, regionally, should be assessed.

---

La importancia de la vigilancia de la circulación del virus de influenza y la vacunación oportuna a las diferentes poblaciones del Perú, fue analizada en tres sesiones por un grupo de clínicos expertos de diferentes especialidades. En Perú, en los últimos años, el sistema nacional de vigilancia de influenza tiene muchos establecimientos seleccionados que son ineficaces en la notificación oportuna. La mayoría de las muestras provienen de Lima. La distribución viral es inadecuadamente analizada. El norte y la selva tienen estaciones climáticas diferentes a Lima y la sierra sur. Esta descoordinación se acentúa con la oportunidad de la llegada de la vacuna de influenza al país. El Ministerio de Salud utiliza una vacuna trivalente pero la posibilidad de una vacuna tetravalente con los dos linajes de tipo B, debe ser analizada desde el punto de vista de costo-beneficio. Se debería evaluar la pertinencia de vacunar en dos momentos anuales, regionalmente.

Asunto(s)

Gripe Humana/prevención & control , Vigilancia de la Población , Adolescente , Adulto , Anciano , Niño , Preescolar , Humanos , Lactante , Vacunas contra la Influenza , Persona de Mediana Edad , Perú , Adulto Joven

RESUMEN

Background: Congenital heart defects (CHDs) are the most common type of birth defects and a major cause of infant mortality. Although knowledge of genetic risk variants for CHDs is scarce, most cases of CHDs are considered to be due to multifactorial inheritance. Objective: To analyze the association of 14 single nucleotide polymorphic variants previously associated with a risk of CHDs in a Mexican population with isolated CHDs. Materials and Methods: DNA samples obtained from healthy subjects and from subjects with isolated atrial, ventricular, or atrioventricular septal defects living in Northeastern Mexico were analyzed by real time-polymerase chain reaction for allelic discrimination of genetic variants of the genes TBX1, TBX20, ASTX-18-AS1, AXIN1, MTHFR, NKX2.5, BMP4, and NFATc1. The odds ratios (ORs) for allele and genotype frequencies and inheritance models were obtained. Results: Forty-two patients and 138 controls were included. Two variants were found to confer a risk of CHDs: variant rs4720169 of TBX20 in which the OR for the heterozygous state was 1.88 (95% confidence interval [CI]: 1.12-3.14, p = 0.010), whereas the OR for the homozygous state was 3.82 (95% CI: 1.18-12.3, p = 0.010); and variant rs12921862 of AXIN1 in which the OR for the heterozygous state was 4.15 (95% CI: 2.42-7.10; p ≤ 0.001), whereas the OR for the homozygous state was 9.2 (95% CI: 1.31-64.7, p = 0.008) for allele A. Conclusion: Genetic variants of the TBX20 and AXIN1 genes confer a significantly increased risk of congenital septal heart defects in a population from Northeastern Mexico.

Asunto(s)

Proteína Axina/genética , Defectos de la Almohadilla Endocárdica/genética , Defectos de los Tabiques Cardíacos/genética , Proteínas de Dominio T Box/genética , Alelos , Estudios de Casos y Controles , Niño , Preescolar , Femenino , Genotipo , Humanos , Lactante , Recién Nacido , Masculino , México , Proyectos Piloto , Polimorfismo de Nucleótido Simple , Estudios Prospectivos

RESUMEN

RESUMEN La importancia de la vigilancia de la circulación del virus de influenza y la vacunación oportuna a las diferentes poblaciones del Perú, fue analizada en tres sesiones por un grupo de clínicos expertos de diferentes especialidades. En Perú, en los últimos años, el sistema nacional de vigilancia de influenza tiene muchos establecimientos seleccionados que son ineficaces en la notificación oportuna. La mayoría de las muestras provienen de Lima. La distribución viral es inadecuadamente analizada. El norte y la selva tienen estaciones climáticas diferentes a Lima y la sierra sur. Esta descoordinación se acentúa con la oportunidad de la llegada de la vacuna de influenza al país. El Ministerio de Salud utiliza una vacuna trivalente pero la posibilidad de una vacuna tetravalente con los dos linajes de tipo B, debe ser analizada desde el punto de vista de costo-beneficio. Se debería evaluar la pertinencia de vacunar en dos momentos anuales, regionalmente.

---

ABSTRACT The importance of surveilling the circulation of the influenza virus and timely vaccination of different populations in Peru was analyzed in three sessions by a group of clinical experts from different specialties. The Peruvian national influenza surveillance system has many selected establishments that have become currently ineffective in terms of a timely report. Most of the samples come from Lima. The viral distribution is inadequately analyzed. The northern and jungle areas of the country have weather and season conditions different to those in Lima and on the southern highlands. This lack of coordination is accentuated by the opportunity of arrival of the influenza vaccine in the country. The Ministry of Health uses a trivalent vaccine but the possibility of a tetravalent vaccine with the two type-B lineages must be analyzed from a cost-benefit standpoint. The appropriateness of vaccinating two times a year, regionally, should be assessed.

Asunto(s)

Adolescente , Adulto , Anciano , Niño , Preescolar , Humanos , Lactante , Persona de Mediana Edad , Adulto Joven , Vigilancia de la Población , Gripe Humana/prevención & control , Perú , Vacunas contra la Influenza

RESUMEN

The Kingdom Plantae has provided several successful drugs for the treatment of different diseases, including cancer, and continues to be a source of new possible therapeutic molecules. For example, the annonaceous acetogenins (AAs) are secondary metabolites found in the Annonaceae family, which are plants employed in traditional medicine for the treatment of cancer and various other diseases. These polyketides are inhibitors of Complex I in the respiratory chain of tumor cells, a process that is closely related to tumor metabolism, cell death, apoptosis, and autophagy. The goal of this review is to update readers on the role of the AAs as antitumor agents using in vitro and in vivo studies to demonstrate their importance in the area of oncology drug discovery. For this purpose, we performed a literature search in the PubMed scientific database using a range of keywords, including acetogenins and cancer, acetogenins antitumor activity, acetogenins and cytotoxicity, and acetogenins mechanism of action, among others. As a result, we found that the AAs are cytotoxic compounds that can induce apoptosis, cell cycle arrest, and autophagy in vitro, in addition to exhibiting tumor growth inhibition in vivo. The functional group related to their antineoplastic activity is suggested to be the mono or bis tetrahydrofuran ring accompanied by two or more hydroxy groups. The versatility of the AA bioactivity therefore renders them potential therapeutic agents for cancer treatment. It is therefore apparent that nature is worth further examination to aid in the discovery of more effective, accurate, and less harmful therapies in the fight against cancer.

RESUMEN

BACKGROUND: Hantavirus cardiopulmonary syndrome (HCPS) has a mortality up to 35-40% and its treatment is mainly supportive. A variable to predict progression from mild to severe disease is unavailable. This study was performed in patients with documented infection by Andes orthohantavirus, and the aim was to find a simple variable to predict progression to moderate/severe HCPS in patients with mild disease at admission. METHODS: We performed a retrospective analysis of 175 patients between 2001 and 2018. Patients were categorized into mild, moderate, and severe disease according to organ failure and advanced support need at hospital admission (e.g., mechanical ventilation, vasopressors). Progression to moderate/severe disease was defined accordingly. Clinical and laboratory variables associated with progression were explored. RESULTS: Forty patients with mild disease were identified; 14 of them progressed to moderate/severe disease. Only platelet count was different between those who progressed versus those that did not (37 (34-58) vs. 83 (64-177) K/mm3, p < 0.001). A ROC curve analysis showed an AUC = 0.889 (0.78-1.0) p < 0.001, with a platelet count greater than 115K /mm3 ruling out progression to moderate/severe disease. CONCLUSIONS: In patients with mild disease at presentation, platelet count could help to define priority of evacuation to tertiary care centers.

Asunto(s)

Infecciones por Hantavirus/sangre , Infecciones por Hantavirus/complicaciones , Síndrome Pulmonar por Hantavirus/sangre , Trombocitopenia/complicaciones , Adulto , Chile , Progresión de la Enfermedad , Femenino , Infecciones por Hantavirus/clasificación , Humanos , Masculino , Persona de Mediana Edad , Recuento de Plaquetas , Curva ROC , Estudios Retrospectivos , Trombocitopenia/virología , Adulto Joven

RESUMEN

We investigated whether likely pathogenic variants co-segregating with gastroschisis through a family-based approach using bioinformatic analyses were implicated in body wall closure. Gene Ontology (GO)/Panther functional enrichment and protein-protein interaction analysis by String identified several biological networks of highly connected genes in UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT1A10, AOX1, NOTCH1, HIST1H2BB, RPS3, THBS1, ADCY9, and FGFR4. SVS-PhoRank identified a dominant model in OR10G4 (also as heterozygous de novo), ITIH3, PLEKHG4B, SLC9A3, ITGA2, AOX1, and ALPP, including a recessive model in UGT1A7, UGT1A6, PER2, PTPRD, and UGT1A3. A heterozygous compound model was observed in CDYL, KDM5A, RASGRP1, MYBPC2, PDE4DIP, F5, OBSCN, and UGT1A. These genes were implicated in pathogenetic pathways involving the following GO related categories: xenobiotic, regulation of metabolic process, regulation of cell adhesion, regulation of gene expression, inflammatory response, regulation of vascular development, keratinization, left-right symmetry, epigenetic, ubiquitination, and regulation of protein synthesis. Multiple background modifiers interacting with disease-relevant pathways may regulate gastroschisis susceptibility. Based in our findings and considering the plausibility of the biological pattern of mechanisms and gene network modeling, we suggest that the gastroschisis developmental process may be the consequence of several well-orchestrated biological and molecular mechanisms which could be interacting with gastroschisis predispositions within the first ten weeks of development.

Asunto(s)

Pared Abdominal/patología , Biología Computacional/métodos , Gastrosquisis/genética , Variación Genética , Ontología de Genes , Humanos , Patrón de Herencia/genética , Mapas de Interacción de Proteínas/genética , Recurrencia