1.
Gematol Transfuziol
; 36(4): 23-5, 1991 Apr.
Artículo
en Ruso
| MEDLINE
| ID: mdl-1712331
RESUMEN
Compounds representing chemically modified derivatives of natural polysaccharides and possessing heparin-like properties have been obtained basing on new methods of sulphatization++ of hydroxyl-containing polymers. The study of the anticoagulation activity of mannan, starch, dextran sulfates permits a suggestion that these compounds realize their anticoagulant potential not through antithrombin-III. A relationship has been established between the properties of semi-synthetic heparinoids and sulfur percentage, molecular mass and the type of polymeric matrix. The investigations conducted have made possible the development of effective thrombosis-preventing drugs and further thorough study of their effects.