RESUMEN

A duplicated nitrotienyl derivative was obtained as a by-product from the synthesis of a proposed molecular hybrid of a nitrotienyl derivative and isoniazid with an expected dual antimycobacteria mechanism. The structure was shown to be the 5,5'-dinitro-2-(2,3-diaza-4-(2'-tienyl)buta-1,3-dienyl)tiophene by X-ray crystallography. The minimal inhibitory concentration (MIC) determination of this compound proved to be promising against Mycobacterium pathogenic strains such as M. avium and M. kansasii, although it had a high level of mutagenicity, as observed in mutagenic activity tests.

Asunto(s)

Antituberculosos/síntesis química , Antituberculosos/farmacología , Mycobacterium avium/efectos de los fármacos , Mycobacterium kansasii/efectos de los fármacos , Nitrocompuestos/síntesis química , Nitrocompuestos/farmacología , Tiofenos/síntesis química , Tiofenos/farmacología , Antituberculosos/química , Cristalografía por Rayos X , Pruebas de Sensibilidad Microbiana , Modelos Moleculares , Estructura Molecular , Nitrocompuestos/química , Relación Estructura-Actividad , Tiofenos/química