Asunto(s)
Proteínas de Unión al ADN/genética , Fibrosarcoma/congénito , Recurrencia Local de Neoplasia , Receptor trkC/genética , Proteínas Represoras , Muslo , Factores de Transcripción/genética , Translocación Genética , Amputación Quirúrgica , Fusión Artificial Génica , Terapia Combinada , Fibrosarcoma/genética , Fibrosarcoma/cirugía , Humanos , Recién Nacido , Cariotipificación , Masculino , Metástasis de la Neoplasia , Proteínas Proto-Oncogénicas c-ets , Proteína ETS de Variante de Translocación 6RESUMEN
Hepatosplenic gamma-delta (gammadelta) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch-preparation of the spleen.
Asunto(s)
Cromosomas Humanos Par 7/genética , Cromosomas Humanos Par 8/genética , Isocromosomas/genética , Neoplasias Hepáticas/genética , Linfoma de Células T/genética , Neoplasias del Bazo/genética , Trisomía/genética , Niño , Citometría de Flujo , Humanos , Hibridación Fluorescente in Situ , Neoplasias Hepáticas/patología , Linfoma de Células T/patología , Masculino , Receptores de Antígenos de Linfocitos T gamma-delta/genética , Neoplasias del Bazo/patologíaRESUMEN
The karyotype of a cystic partially differentiated nephroblastoma (CPDN) was found to be 51, XY, +7, +8, +12, +13, +17. A review of the literature disclosed three other cytogenetically analyzed CPDNs. As in this case, they were all hyperdiploid. The only chromosomal anomaly common to all four cases was trisomy 12, suggesting this chromosome might have a pathogenetic role. Earlier reports had tentatively attributed this role to chromosome 8.
Asunto(s)
Cromosomas Humanos Par 12 , Diploidia , Enfermedades Renales Quísticas/patología , Neoplasias Renales/patología , Trisomía , Tumor de Wilms/patología , Diferenciación Celular , Humanos , Lactante , Enfermedades Renales Quísticas/genética , Neoplasias Renales/genética , Masculino , Tumor de Wilms/genéticaRESUMEN
We report the cytogenetic analysis of a choroid plexus papilloma, a benign tumor, with a modal number of 56 chromosomes. In our review of the few reported karyotypes of choroid plexus tumors, we found no predictive relationship between the karyotype and the pathologic diagnosis or outcome.