RESUMEN
A retrospective analysis of data on 27 patients with uterine choriocarcinoma metastatic to the brain and other distant sites treated at the Center's Clinic (1980-1996) has been undertaken. Advantages offered by combined treatment (irradiation of the brain + combination chemotherapy) of 15 patients are discussed and practical advice is given.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias Encefálicas/radioterapia , Neoplasias Encefálicas/secundario , Coriocarcinoma/radioterapia , Coriocarcinoma/secundario , Neoplasias Uterinas/patología , Adulto , Neoplasias Encefálicas/tratamiento farmacológico , Quimioterapia Adyuvante , Coriocarcinoma/tratamiento farmacológico , Femenino , Humanos , Persona de Mediana Edad , Radioterapia Adyuvante , Estudios Retrospectivos , Análisis de Supervivencia , Resultado del Tratamiento , Neoplasias Uterinas/tratamiento farmacológicoRESUMEN
Brain irradiation for metastases was performed in 3 cases of choriocarcinoma of pregnancy and 1 patient with testicular choriocarcinoma of embryonal origin. Treatment failed in 2 cases due to tumor advancement, while the other 2 patients showed marked response. Early diagnosis and proper treatment of intracranial metastases may significantly increase survival.
Asunto(s)
Neoplasias Encefálicas/radioterapia , Neoplasias Encefálicas/secundario , Coriocarcinoma/radioterapia , Neoplasias Testiculares/radioterapia , Neoplasias Uterinas/radioterapia , Adulto , Terapia Combinada , Femenino , Rayos gamma/uso terapéutico , Humanos , Neoplasias Pulmonares/radioterapia , Neoplasias Pulmonares/secundario , Metástasis Linfática , Masculino , Embarazo , Dosificación RadioterapéuticaAsunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias Trofoblásticas/tratamiento farmacológico , Neoplasias Uterinas/tratamiento farmacológico , Adolescente , Adulto , Evaluación de Medicamentos , Femenino , Humanos , Neoplasias Pulmonares/tratamiento farmacológico , Neoplasias Pulmonares/mortalidad , Neoplasias Pulmonares/secundario , Persona de Mediana Edad , Embarazo , Neoplasias Trofoblásticas/mortalidad , Neoplasias Uterinas/mortalidadRESUMEN
An evaluation of 801 cases of different forms of uterine trophoblastic tumors treated at the Center in 1960-1981 is given. Chorionepithelioma was confirmed histologically in 488 cases. Modern means of diagnosis of uterine trophoblastic tumors are discussed. A retrospective analysis of treatment of patients is presented. The result of up-to-date combination chemotherapy of patients with uterine chorionepithelioma are reported. The role of surgery in the treatment of trophoblastic tumors is discussed.
Asunto(s)
Neoplasias Trofoblásticas/diagnóstico , Neoplasias Uterinas/diagnóstico , Adulto , Coriocarcinoma/diagnóstico , Coriocarcinoma/mortalidad , Coriocarcinoma/terapia , Gonadotropina Coriónica/sangre , Femenino , Humanos , Estadificación de Neoplasias , Embarazo , Glicoproteínas beta 1 Específicas del Embarazo/análisis , Neoplasias Trofoblásticas/mortalidad , Neoplasias Trofoblásticas/terapia , Neoplasias Uterinas/mortalidad , Neoplasias Uterinas/terapiaAsunto(s)
Enfermedades Gastrointestinales/prevención & control , Metotrexato/efectos adversos , Neoplasias Trofoblásticas/tratamiento farmacológico , Neoplasias Uterinas/tratamiento farmacológico , Carbono/uso terapéutico , Ensayos Clínicos como Asunto , Femenino , Ácido Fólico/administración & dosificación , Ácido Fólico/uso terapéutico , Enfermedades Gastrointestinales/inducido químicamente , Humanos , Metotrexato/uso terapéutico , Vehículos Farmacéuticos , Embarazo , SuspensionesRESUMEN
The authors determined beta1-G-globulin (beta1GG) in the sera of patients with different malignant tumours and of normal donors by means of the immunodiffusion method (ID) and immunoautoradiography (IAR). In the ID-negative sera beta1GG was revealed by means of IAR in 7 out of 8 patients with chorionepithelioma of the uterus and in 1 out of 7 patients with teratomblastoma of the testis before the treatment. After the treatment the beta1GG was determined in 7 out of 21 patients with chorionepithelioma of the uterus. At the early stage of trophoblastic tumours of the uterus beta1GG could be found in 77.7% of cases by means of IAR and in 16.8% of cases by means of the ID method.