RESUMEN
Implantation of somatic cells from autopsy specimens (15-18 weeks gestation) had a modulatory effect on immunogenesis in old mice. Activation of the immune system in recipient animals after administration of somatic cells reflects a multistage influence of test preparation. The observed changes were reversible. A progressive decrease in activation of the immune system in recipient mice was not accompanied by the development of pathological changes. Repeated implantation was required to maintain these processes.
Asunto(s)
Trasplante de Células , Animales , Ratones , Ratones Endogámicos CBARESUMEN
The thymus glands from one hundred of 4--34-week-old human fetuses were studied by the histologic, histochemical, immunomorphologic and electron microscopic methods. The development of the organ is described from the standpoint of systemogenesis. The laying of the gland is defined at the 5th week of the fetus development, and it reflects the features of the epithelium of the head intestine organs. The differentiation of the reticuloepithelium, the population of the gland by lymphocytes and emergence of antigenic specificity on their surface state at the age of 7--8 weeks. The growth zone of the thymus reticuloepithelium, the significance of Hassal's bodies, the appearance and quantitative dynamics of two subpopulations of T-lymphocytes are described. From 11--12 till 34 weeks of fetal development the percentage of T-lymphocytes forming rosettes with sheep red blood cells virtually does not change (70--90%), while the percentage of lymphocytes forming rosettes with their own red cell increases during the same period from 23 to 70%.
Asunto(s)
Timo/embriología , Edad Gestacional , Humanos , Microscopía Electrónica , Morfogénesis , Timo/inmunología , Timo/ultraestructuraRESUMEN
Experiments were conducted on rats. The influence of the serum of a burn convalescent on the toxic properties, the level of proteolytic enzymes activity, and morphological changes following burn were studied. After the burn the blood serum and the extracts of the organs acquired toxic properties; there was an increase in the activity of proteolytic enzymes, and marked morphological changes developed Administration of the serum of aburn convalescent promoted detoxication, diminished the activity of proteolytic enzymes distinctly, and decreased the morphological disturbances.